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Single-Nucleotide Polymorphisms, c.415C > T (Arg139Cys) and c.416G > A (Arg139His), in the NUDT15 Gene Are Associated with Thiopurine-Induced Leukopenia.
http://hdl.handle.net/10422/00013551
http://hdl.handle.net/10422/000135511b51716c-09e2-4872-89cc-73a56eac2432
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
bpb.b22-00686 (970.4 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2023-04-27 | |||||
| タイトル | ||||||
| タイトル | Single-Nucleotide Polymorphisms, c.415C > T (Arg139Cys) and c.416G > A (Arg139His), in the NUDT15 Gene Are Associated with Thiopurine-Induced Leukopenia. | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | nucleoside diphosphate-linked moiety X-type motif 15 (NUDT15) | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | thiopurine | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | polymorphism | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | leukopenia | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 著者 |
ISONO, Tetsuichiro
× ISONO, Tetsuichiro× HIRA, Daiki× IKEDA, Yoshito× KAWAHARA, Masahiro× NODA, Satoshi× NISHIDA, Atsushi× INATOMI, Osamu× FUJIMOTO, Noriki× ANDOH, Akira× TERADA, Tomohiro× MORITA, Shin-ya |
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| 著者別名 |
磯野, 哲一郎
× 磯野, 哲一郎× 平, 大樹× 池田, 義人× 河原, 真大× 野田, 哲史× 西田, 淳史× 稲富, 理× 藤本, 徳毅× 安藤, 朗× 寺田, 智祐× 森田, 真也 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | While nucleoside diphosphate-linked moiety X-type motif 15 (NUDT15) gene polymorphism Arg139Cys (rs116855232) is known to be a risk factor for thiopurine-induced severe leukopenia, association with the NUDT15 gene polymorphism Arg139His (rs147390019) has not yet been clarified. In addition, the accuracy of TaqMan PCR to assess these two polymorphisms has not been investigated. In this study, we evaluated TaqMan PCR for detection of the NUDT15 single-nucleotide polymorphisms (SNPs) and examined the clinical impact of Arg139His on thiopurine-induced leukopenia. First, we demonstrated that a TaqMan PCR assay successfully detected the Arg139His polymorphism of NUDT15 in clinical samples. Next, the NUDT15 gene polymorphisms (Arg139Cys and Arg139His) were separately analyzed by TaqMan Real-Time PCR in 189 patients from August 2018 to July 2019. The incidences of leukopenia within 2 years were 16.2, 57.9, and 100% for arginine (Arg)/Arg, Arg/cysteine (Cys), and Arg/histidine (His), respectively. The leukopenia was significantly increased in Arg/Cys and Arg/His compared with Arg/Arg. This retrospective clinical study indicated that, in addition to Arg139Cys, Arg139His may be clinically associated with a high risk of leukopenia. Pharmacogenomics will help in selecting drugs and determining the individualized dosage of thiopurine drugs. | |||||
| 言語 | en | |||||
| 書誌情報 |
en : Biological & pharmaceutical bulletin 巻 46, 号 3, p. 412-418, 発行日 2023-03-01 |
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| 出版者 | ||||||
| 出版者 | Pharmaceutical Society of Japan | |||||
| 言語 | en | |||||
| 別言語の出版者 | ||||||
| 出版者 | 日本薬学会 | |||||
| 言語 | ja | |||||
| ISSN | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 1347-5215 | |||||
| PMID | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 36858569 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1248/bpb.b22-00686 | |||||
| 権利 | ||||||
| 言語 | en | |||||
| 権利情報 | © 2023 The Pharmaceutical Society of Japan | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
