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Vascular smooth muscle RhoA counteracts abdominal aortic aneurysm formation by modulating MAP4K4 activity
http://hdl.handle.net/10422/00013454
http://hdl.handle.net/10422/000134542e622445-0122-4bc0-8c6c-1126e81e1c88
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s42003-022-04042-z (5.6 MB)
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s42003-022-04042-z_Supplementary information (23.6 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2022-11-14 | |||||
| タイトル | ||||||
| タイトル | Vascular smooth muscle RhoA counteracts abdominal aortic aneurysm formation by modulating MAP4K4 activity | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Aneurysm | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Mechanisms of disease | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
MOLLA, Md Rasel
× MOLLA, Md Rasel× SHIMIZU, Akio× KOMENO, Masahiro× RAHMAN, Nor Idayu A.× SOH, Joanne Ern Chi× NGUYEN, Le Kim Chi× RAHMAN KHAN, Mahbubur× TESEGA, Wondwossen Wale× CHEN, Si× PANG, Xiaoling× TANAKA-OKAMOTO, Miki× TAKASHIMA, Noriyuki× SATO, Akira× SUZUKI, Tomoaki× OGITA, Hisakazu |
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| 著者別名 |
清水, 昭男
× 清水, 昭男× 米野, 雅大× 髙島, 範之× 佐藤, 朗× 鈴木, 友彰× 扇田, 久和 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Whether a small GTPase RhoA plays a role in the pathology of abdominal aortic aneurysm (AAA) has not been determined. We show here that RhoA expression is reduced in human AAA lesions, compared with normal areas. Furthermore, incidence of AAA formation is increased in vascular smooth muscle cell (VSMC)-specific RhoA conditional knockout (cKO) mice. The contractility of the aortic rings and VSMCs from RhoA cKO mice is reduced, and expression of genes related to the VSMC contractility is attenuated by loss of RhoA. RhoA depletion activates the mitogen-activated protein (MAP) kinase signaling, including MAP4K4, in the aorta and VSMCs. Inhibition of MAP4K4 activity by DMX-5804 decreases AAA formation. Set, a binding protein to active RhoA, functions as an activator of MAP4K4 by sequestering PP2A, an inhibitor of MAP4K4, in the absence of RhoA. In conclusion, RhoA counteracts AAA formation through inhibition of MAP4K4 in cooperation with Set. | |||||
| 書誌情報 |
en : Communications Biology 巻 5, 号 1, 発行日 2022-10-07 |
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| 出版者 | ||||||
| 出版者 | Springer Nature | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 2399-3642 | |||||
| PMID | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 36207400 | |||||
| PMCID | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.ncbi.nlm.nih.gov/pmc/articles/pmc9546906/ | |||||
| 関連名称 | PMC9546906 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1038/s42003-022-04042-z | |||||
| 関連名称 | 10.1038/s42003-022-04042-z | |||||
| 権利 | ||||||
| 権利情報 | © 2022. The Author(s). | |||||
| フォーマット | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
| フォーマット | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | application/xlsx | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Journal Article | |||||
