{"created":"2023-06-19T10:44:00.497900+00:00","id":4375,"links":{},"metadata":{"_buckets":{"deposit":"e3cb3db4-3da3-49e6-a87d-d0ad2cd93868"},"_deposit":{"created_by":11,"id":"4375","owners":[11],"pid":{"revision_id":0,"type":"depid","value":"4375"},"status":"published"},"_oai":{"id":"oai:shiga-med.repo.nii.ac.jp:00004375","sets":["30:229:230","30:89:90"]},"author_link":["8530","9184","3183","6087","8527","8529","9185","6732","8544","8531","6179","7848","6731","9183","7847"],"item_4_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-10-07","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicVolumeNumber":"5","bibliographic_titles":[{},{"bibliographic_title":"Communications Biology","bibliographic_titleLang":"en"}]}]},"item_4_creator_3":{"attribute_name":"著者別名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"清水, 昭男"}],"nameIdentifiers":[{"nameIdentifier":"6731","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"30769279","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=30769279"},{"nameIdentifier":"0000-0002-3393-6193","nameIdentifierScheme":"ORCID","nameIdentifierURI":"https://orcid.org/0000-0002-3393-6193"}]},{"creatorNames":[{"creatorName":"米野, 雅大"}],"nameIdentifiers":[{"nameIdentifier":"7848","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"髙島, 範之"}],"nameIdentifiers":[{"nameIdentifier":"6087","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"80402709","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=80402709"}]},{"creatorNames":[{"creatorName":"佐藤, 朗"}],"nameIdentifiers":[{"nameIdentifier":"7847","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"70464302","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=70464302"}]},{"creatorNames":[{"creatorName":"鈴木, 友彰"}],"nameIdentifiers":[{"nameIdentifier":"3183","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"80402709","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=80402709"},{"nameIdentifier":"0000-0001-5836-899X","nameIdentifierScheme":"ORCID","nameIdentifierURI":"https://orcid.org/0000-0001-5836-899X"}]},{"creatorNames":[{"creatorName":"扇田, 久和"}],"nameIdentifiers":[{"nameIdentifier":"6179","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"50379236","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=50379236"},{"nameIdentifier":"0000-0001-6750-1668","nameIdentifierScheme":"ORCID","nameIdentifierURI":"https://orcid.org/0000-0001-6750-1668"}]}]},"item_4_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"},{"subitem_description":"application/xlsx","subitem_description_type":"Other"}]},"item_4_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Whether a small GTPase RhoA plays a role in the pathology of abdominal aortic aneurysm (AAA) has not been determined. We show here that RhoA expression is reduced in human AAA lesions, compared with normal areas. Furthermore, incidence of AAA formation is increased in vascular smooth muscle cell (VSMC)-specific RhoA conditional knockout (cKO) mice. The contractility of the aortic rings and VSMCs from RhoA cKO mice is reduced, and expression of genes related to the VSMC contractility is attenuated by loss of RhoA. RhoA depletion activates the mitogen-activated protein (MAP) kinase signaling, including MAP4K4, in the aorta and VSMCs. Inhibition of MAP4K4 activity by DMX-5804 decreases AAA formation. Set, a binding protein to active RhoA, functions as an activator of MAP4K4 by sequestering PP2A, an inhibitor of MAP4K4, in the absence of RhoA. In conclusion, RhoA counteracts AAA formation through inhibition of MAP4K4 in cooperation with Set. ","subitem_description_type":"Abstract"}]},"item_4_description_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Journal Article","subitem_description_type":"Other"}]},"item_4_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer Nature"}]},"item_4_relation_10":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"36207400","subitem_relation_type_select":"PMID"}}]},"item_4_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"10.1038/s42003-022-04042-z"}],"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1038/s42003-022-04042-z","subitem_relation_type_select":"DOI"}}]},"item_4_relation_13":{"attribute_name":"PMCID","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"PMC9546906"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.ncbi.nlm.nih.gov/pmc/articles/pmc9546906/","subitem_relation_type_select":"URI"}}]},"item_4_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2022. The Author(s). "}]},"item_4_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2399-3642","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"MOLLA, Md Rasel"}],"nameIdentifiers":[{"nameIdentifier":"8529","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"0000-0003-1059-3201","nameIdentifierScheme":"ORCID","nameIdentifierURI":"https://orcid.org/0000-0003-1059-3201"}]},{"creatorNames":[{"creatorName":"SHIMIZU, Akio"}],"nameIdentifiers":[{"nameIdentifier":"6731","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"30769279","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=30769279"},{"nameIdentifier":"0000-0002-3393-6193","nameIdentifierScheme":"ORCID","nameIdentifierURI":"https://orcid.org/0000-0002-3393-6193"}]},{"creatorNames":[{"creatorName":"KOMENO, Masahiro"}],"nameIdentifiers":[{"nameIdentifier":"7848","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"RAHMAN, Nor Idayu A."}],"nameIdentifiers":[{"nameIdentifier":"8527","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"SOH, Joanne Ern Chi"}],"nameIdentifiers":[{"nameIdentifier":"8530","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"0000-0002-1940-860X","nameIdentifierScheme":"ORCID","nameIdentifierURI":"https://orcid.org/0000-0002-1940-860X"}]},{"creatorNames":[{"creatorName":"NGUYEN, Le Kim Chi"}],"nameIdentifiers":[{"nameIdentifier":"8531","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"RAHMAN KHAN, Mahbubur"}],"nameIdentifiers":[{"nameIdentifier":"9183","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"TESEGA, Wondwossen Wale"}],"nameIdentifiers":[{"nameIdentifier":"9184","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"0000-0001-8577-5793","nameIdentifierScheme":"ORCID","nameIdentifierURI":"https://orcid.org/0000-0001-8577-5793"}]},{"creatorNames":[{"creatorName":"CHEN, Si"}],"nameIdentifiers":[{"nameIdentifier":"9185","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"PANG, Xiaoling"}],"nameIdentifiers":[{"nameIdentifier":"8544","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"TANAKA-OKAMOTO, Miki"}],"nameIdentifiers":[{"nameIdentifier":"6732","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"TAKASHIMA, Noriyuki"}],"nameIdentifiers":[{"nameIdentifier":"6087","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"80402709","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=80402709"}]},{"creatorNames":[{"creatorName":"SATO, Akira"}],"nameIdentifiers":[{"nameIdentifier":"7847","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"70464302","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=70464302"}]},{"creatorNames":[{"creatorName":"SUZUKI, Tomoaki"}],"nameIdentifiers":[{"nameIdentifier":"3183","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"80402709","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=80402709"},{"nameIdentifier":"0000-0001-5836-899X","nameIdentifierScheme":"ORCID","nameIdentifierURI":"https://orcid.org/0000-0001-5836-899X"}]},{"creatorNames":[{"creatorName":"OGITA, Hisakazu"}],"nameIdentifiers":[{"nameIdentifier":"6179","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"50379236","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=50379236"},{"nameIdentifier":"0000-0001-6750-1668","nameIdentifierScheme":"ORCID","nameIdentifierURI":"https://orcid.org/0000-0001-6750-1668"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-11-14"}],"displaytype":"detail","filename":"s42003-022-04042-z.pdf","filesize":[{"value":"5.6 MB"}],"format":"application/pdf","license_note":"This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. 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