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  1. 医学科
  2. 内科学講座 消化器・血液
  3. 学術雑誌掲載論文等(内科学講座 消化器・血液)

Ustekinumab trough levels predicting laboratory and endoscopic remission in patients with Crohn's disease

http://hdl.handle.net/10422/00013292
http://hdl.handle.net/10422/00013292
e0d2214b-4d41-4726-aa2a-6155607fe65d
名前 / ファイル ライセンス アクション
s12876-022-02271-4.pdf s12876-022-02271-4 (1.1 MB)
This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
Item type 学術雑誌論文 / Journal Article(1)
公開日 2022-05-10
タイトル
タイトル Ustekinumab trough levels predicting laboratory and endoscopic remission in patients with Crohn's disease
言語
言語 eng
キーワード
言語 en
主題Scheme Other
主題 Ustekinumab
キーワード
言語 en
主題Scheme Other
主題 Therapeutic drug monitoring
キーワード
言語 en
主題Scheme Other
主題 Enteroscopy
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
著者 HIRAYAMA, Hisashi

× HIRAYAMA, Hisashi

WEKO 8977

HIRAYAMA, Hisashi

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MORITA, Yasuhiro

× MORITA, Yasuhiro

WEKO 8019
ORCID 0000-0002-4875-662X

MORITA, Yasuhiro

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IMAI, Takayuki

× IMAI, Takayuki

WEKO 7638
ORCID 0000-0002-9170-4075

IMAI, Takayuki

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TAKAHASHI, Kenichiro

× TAKAHASHI, Kenichiro

WEKO 6092
e-Rad 20773493
ORCID 0000-0002-3522-9740

TAKAHASHI, Kenichiro

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YOSHIDA, Atsushi

× YOSHIDA, Atsushi

WEKO 8978

YOSHIDA, Atsushi

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BAMBA, Shigeki

× BAMBA, Shigeki

WEKO 707
e-Rad 40422901
ORCID 0000-0002-4108-5894

BAMBA, Shigeki

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INATOMI, Osamu

× INATOMI, Osamu

WEKO 706
e-Rad 70530351
ORCID 0000-0002-5837-6575

INATOMI, Osamu

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ANDOH, Akira

× ANDOH, Akira

WEKO 644
e-Rad 90252395
ORCID 0000-0001-8533-2669

ANDOH, Akira

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著者別名 平山, 尚史

× 平山, 尚史

WEKO 8977

平山, 尚史

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森田, 康大

× 森田, 康大

WEKO 8019
ORCID 0000-0002-4875-662X

森田, 康大

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今井, 隆行

× 今井, 隆行

WEKO 7638
ORCID 0000-0002-9170-4075

今井, 隆行

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高橋, 憲一郎

× 高橋, 憲一郎

WEKO 6092
e-Rad 20773493
ORCID 0000-0002-3522-9740

高橋, 憲一郎

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馬場, 重樹

× 馬場, 重樹

WEKO 707
e-Rad 40422901
ORCID 0000-0002-4108-5894

馬場, 重樹

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稲富, 理

× 稲富, 理

WEKO 706
e-Rad 70530351
ORCID 0000-0002-5837-6575

稲富, 理

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安藤, 朗

× 安藤, 朗

WEKO 644
e-Rad 90252395
ORCID 0000-0001-8533-2669

安藤, 朗

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抄録
内容記述タイプ Abstract
内容記述 Backgrounds:
Optimal concentration of ustekinumab (UST) predicting endoscopic remission has not been fully investigated in Crohn's disease (CD). We aimed to identify the optimal UST trough levels predicting clinical, laboratory and endoscopic remission in CD patients.
抄録
内容記述タイプ Abstract
内容記述 Methods:
Twenty-eight patients with CD were enrolled and investigated (27 patients by enteroscopy and 1 by colonoscopy). The endoscopic activity was assessed using the scoring system that applied the Rutgeerts score to observed intestine. Serum UST trough levels and anti-UST antibodies (AUAs) levels were determined by in-house immunoassays.
抄録
内容記述タイプ Abstract
内容記述 Results:
Endoscopic activity was negatively correlated with serum UST trough levels (Spearman's rank correlation coefficient (ρ) = - 0.66, P = 0.0001) and serum albumin levels (ρ = - 0.60, P = 0.0007). The endoscopic activity was positively and significantly correlated with CRP (ρ = 0.59, P = 0.0009) and ESR (ρ = 0.44, P = 0.033). There was no significant association between the endoscopic score and AUA levels and/or Crohn's disease activity index (CDAI). Serum UST trough levels and albumin levels were significantly higher in the endoscopic remission group (scores of 0 and 1) than in the non-endoscopic remission group (UST trough, mean 3.3 vs. 1.8 μg/mL). No significant difference was observed in AUAs between the endoscopic remission and non-remission groups. Receiver operation curve (ROC) analysis revealed that the optimal cutoff value of UST trough levels predicting normal CRP and serum albumin levels was 1.7 μg/mL for each, and the optimal cutoff value predicting endoscopic remission was 2.0 μg/mL (AUC: 0.80, 95% CI 0.64-0.96).
抄録
内容記述タイプ Abstract
内容記述 Conclusion:
Achievement of endoscopic remission requires higher UST trough levels than required for normalization of CRP and serum albumin levels.
書誌情報 en : BMC Gastroenterology

巻 22, 号 1, 発行日 2022-04-21
出版者
出版者 BioMed Central Ltd
ISSN
収録物識別子タイプ ISSN
収録物識別子 1471-230X
PMID
関連タイプ isIdenticalTo
識別子タイプ PMID
関連識別子 35448957
PMCID
識別子タイプ URI
関連識別子 http://www.ncbi.nlm.nih.gov/pmc/articles/pmc9027696/
関連名称 PMC9027696
DOI
関連タイプ isIdenticalTo
識別子タイプ DOI
関連識別子 https://doi.org/10.1186/s12876-022-02271-4
関連名称 10.1186/s12876-022-02271-4
権利
権利情報 © 2022. The Author(s).
フォーマット
内容記述タイプ Other
内容記述 pdf
著者版フラグ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
資源タイプ
内容記述タイプ Other
内容記述 Journal Article
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