{"created":"2023-06-19T10:43:51.707536+00:00","id":4205,"links":{},"metadata":{"_buckets":{"deposit":"6a72f925-a0b0-438a-acee-0f93884439bf"},"_deposit":{"created_by":11,"id":"4205","owners":[11],"pid":{"revision_id":0,"type":"depid","value":"4205"},"status":"published"},"_oai":{"id":"oai:shiga-med.repo.nii.ac.jp:00004205","sets":["30:227:228"]},"author_link":["8019","706","6092","8978","7638","8977","644","707"],"item_4_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-04-21","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicVolumeNumber":"22","bibliographic_titles":[{},{"bibliographic_title":"BMC Gastroenterology","bibliographic_titleLang":"en"}]}]},"item_4_creator_3":{"attribute_name":"著者別名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"平山, 尚史"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"森田, 康大"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"今井, 隆行"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"高橋, 憲一郎"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"馬場, 重樹"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"稲富, 理"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"安藤, 朗"}],"nameIdentifiers":[{},{},{}]}]},"item_4_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"pdf","subitem_description_type":"Other"}]},"item_4_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Backgrounds:\nOptimal concentration of ustekinumab (UST) predicting endoscopic remission has not been fully investigated in Crohn's disease (CD). We aimed to identify the optimal UST trough levels predicting clinical, laboratory and endoscopic remission in CD patients. ","subitem_description_type":"Abstract"},{"subitem_description":"Methods:\nTwenty-eight patients with CD were enrolled and investigated (27 patients by enteroscopy and 1 by colonoscopy). The endoscopic activity was assessed using the scoring system that applied the Rutgeerts score to observed intestine. Serum UST trough levels and anti-UST antibodies (AUAs) levels were determined by in-house immunoassays. ","subitem_description_type":"Abstract"},{"subitem_description":"Results:\nEndoscopic activity was negatively correlated with serum UST trough levels (Spearman's rank correlation coefficient (ρ) = - 0.66, P = 0.0001) and serum albumin levels (ρ = - 0.60, P = 0.0007). The endoscopic activity was positively and significantly correlated with CRP (ρ = 0.59, P = 0.0009) and ESR (ρ = 0.44, P = 0.033). There was no significant association between the endoscopic score and AUA levels and/or Crohn's disease activity index (CDAI). Serum UST trough levels and albumin levels were significantly higher in the endoscopic remission group (scores of 0 and 1) than in the non-endoscopic remission group (UST trough, mean 3.3 vs. 1.8 μg/mL). No significant difference was observed in AUAs between the endoscopic remission and non-remission groups. Receiver operation curve (ROC) analysis revealed that the optimal cutoff value of UST trough levels predicting normal CRP and serum albumin levels was 1.7 μg/mL for each, and the optimal cutoff value predicting endoscopic remission was 2.0 μg/mL (AUC: 0.80, 95% CI 0.64-0.96).","subitem_description_type":"Abstract"},{"subitem_description":"Conclusion:\nAchievement of endoscopic remission requires higher UST trough levels than required for normalization of CRP and serum albumin levels. ","subitem_description_type":"Abstract"}]},"item_4_description_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Journal Article","subitem_description_type":"Other"}]},"item_4_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"BioMed Central Ltd"}]},"item_4_relation_10":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"35448957","subitem_relation_type_select":"PMID"}}]},"item_4_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"10.1186/s12876-022-02271-4"}],"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1186/s12876-022-02271-4","subitem_relation_type_select":"DOI"}}]},"item_4_relation_13":{"attribute_name":"PMCID","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"PMC9027696"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.ncbi.nlm.nih.gov/pmc/articles/pmc9027696/","subitem_relation_type_select":"URI"}}]},"item_4_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2022. The Author(s). "}]},"item_4_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1471-230X","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"HIRAYAMA, Hisashi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"MORITA, Yasuhiro"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"IMAI, Takayuki"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"TAKAHASHI, Kenichiro"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"YOSHIDA, Atsushi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"BAMBA, Shigeki"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"INATOMI, Osamu"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"ANDOH, Akira"}],"nameIdentifiers":[{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-05-10"}],"displaytype":"detail","filename":"s12876-022-02271-4.pdf","filesize":[{"value":"1.1 MB"}],"format":"application/pdf","license_note":"This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"s12876-022-02271-4","url":"https://shiga-med.repo.nii.ac.jp/record/4205/files/s12876-022-02271-4.pdf"},"version_id":"edb22014-80f7-49d1-b7ec-8d968c704586"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Ustekinumab","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Therapeutic drug monitoring","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Enteroscopy","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Ustekinumab trough levels predicting laboratory and endoscopic remission in patients with Crohn's disease","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Ustekinumab trough levels predicting laboratory and endoscopic remission in patients with Crohn's disease"}]},"item_type_id":"4","owner":"11","path":["228"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-05-10"},"publish_date":"2022-05-10","publish_status":"0","recid":"4205","relation_version_is_last":true,"title":["Ustekinumab trough levels predicting laboratory and endoscopic remission in patients with Crohn's disease"],"weko_creator_id":"11","weko_shared_id":-1},"updated":"2023-06-19T11:16:04.923776+00:00"}