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The anti-inflammatory and protective role of interleukin-38 in inflammatory bowel disease.
http://hdl.handle.net/10422/00013201
http://hdl.handle.net/10422/0001320159c540f9-5d40-4676-82f6-f56c6ee76197
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jcbn.21-104 (3.4 MB)
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This is an open access article distributed under the terms of the Creative
Commons Attribution-NonCommercial-NoDerivatives License. https://creativecommons.org/licenses/by-nc-nd/4.0/ |
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jcbn.21-104_Supplemental Table1 (50.1 kB)
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This is an open access article distributed under the terms of the Creative
Commons Attribution-NonCommercial-NoDerivatives License. https://creativecommons.org/licenses/by-nc-nd/4.0/ |
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jcbn.21-104_Supplemental Table2 (27.6 kB)
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This is an open access article distributed under the terms of the Creative
Commons Attribution-NonCommercial-NoDerivatives License. https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2022-02-02 | |||||
| タイトル | ||||||
| タイトル | The anti-inflammatory and protective role of interleukin-38 in inflammatory bowel disease. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | inflammatory bowel disease | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | ulcerative colitis | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | interleukin-38 | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | interleukin-36 | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
OHNO, Masashi
× OHNO, Masashi× IMAI, Takayuki× CHATANI, Motoharu× NISHIDA, Atsushi× INATOMI, Osamu× KAWAHARA, Masahiro× HOSHINO, Tomoaki× ANDOH, Akira |
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| 著者別名 |
大野, 将司
× 大野, 将司× 今井, 隆行× 茶谷, 元晴× 西田, 淳史× 稲富, 理× 河原, 真大× 安藤, 朗 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Interleukin (IL)-38 exerts an anti-inflammatory function by binding to several cytokine receptors, including the IL-36 receptor. In this study, we evaluated IL-38 expression in the inflamed mucosa of patients with inflammatory bowel disease (IBD) and investigated its functions. IL-38 mRNA expression in endoscopic biopsy samples was evaluated using quantitative PCR. IL-38 protein expression was analyzed using immunohistochemical technique. Dextran sulfate sodium-induced colitis was induced in C57BL/6 background IL-38KO mice. The IL-38 mRNA and protein expression were enhanced in the active mucosa of ulcerative colitis, but not in Crohn's disease. The ratio of IL-36γ to IL-38 mRNA expression was significantly elevated in the active mucosa of UC patients. Immunofluorescence staining revealed that B cells are the major cellular source of IL-38 in the colonic mucosa. IL-38 dose-dependently suppressed the IL-36γ-induced mRNA expression of CXC chemokines (CXCL1, CXCL2, and CXCL8) in HT-29 and T84 cells. IL-38 inhibited the IL-36γ-induced activation of nuclear-factor kappa B (NF-κB) and mitogen-activated protein kinases in HT-29 cells. DSS-colitis was significantly exacerbated in IL-38KO mice compared to wild type mice. In conclusion, IL-38 may play an anti-inflammatory and protective role in the pathophysiology of IBD, in particular ulcerative colitis, through the suppression of IL-36-induced inflammatory responses. | |||||
| 書誌情報 |
en : Journal of Clinical Biochemistry and Nutrition 巻 70, 号 1, p. 64-71, 発行日 2022-01 |
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| 出版者 | ||||||
| 出版者 | The Society for Free Radical Research Japan | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0912-0009 | |||||
| PMID | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 35068683 | |||||
| PMCID | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.ncbi.nlm.nih.gov/pmc/articles/pmc8764106/ | |||||
| 関連名称 | PMC8764106 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.3164/jcbn.21-104 | |||||
| 関連名称 | 10.3164/jcbn.21-104 | |||||
| 権利 | ||||||
| 権利情報 | © 2022 JCBN | |||||
| フォーマット | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | ||||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Journal Article | |||||
