{"created":"2023-06-19T10:43:47.383980+00:00","id":4107,"links":{},"metadata":{"_buckets":{"deposit":"b3de5509-fa59-435d-87f6-ad2118258016"},"_deposit":{"created_by":11,"id":"4107","owners":[11],"pid":{"revision_id":0,"type":"depid","value":"4107"},"status":"published"},"_oai":{"id":"oai:shiga-med.repo.nii.ac.jp:00004107","sets":["30:227:228"]},"author_link":["706","8835","7253","7638","644","8836","7639","7509"],"item_4_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"71","bibliographicPageStart":"64","bibliographicVolumeNumber":"70","bibliographic_titles":[{},{"bibliographic_title":"Journal of Clinical Biochemistry and Nutrition","bibliographic_titleLang":"en"}]}]},"item_4_creator_3":{"attribute_name":"著者別名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"大野, 将司"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"今井, 隆行"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"茶谷, 元晴"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"西田, 淳史"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"稲富, 理"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"河原, 真大"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"安藤, 朗"}],"nameIdentifiers":[{},{},{}]}]},"item_4_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"pdf","subitem_description_type":"Other"}]},"item_4_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Interleukin (IL)-38 exerts an anti-inflammatory function by binding to several cytokine receptors, including the IL-36 receptor. In this study, we evaluated IL-38 expression in the inflamed mucosa of patients with inflammatory bowel disease (IBD) and investigated its functions. IL-38 mRNA expression in endoscopic biopsy samples was evaluated using quantitative PCR. IL-38 protein expression was analyzed using immunohistochemical technique. Dextran sulfate sodium-induced colitis was induced in C57BL/6 background IL-38KO mice. The IL-38 mRNA and protein expression were enhanced in the active mucosa of ulcerative colitis, but not in Crohn's disease. The ratio of IL-36γ to IL-38 mRNA expression was significantly elevated in the active mucosa of UC patients. Immunofluorescence staining revealed that B cells are the major cellular source of IL-38 in the colonic mucosa. IL-38 dose-dependently suppressed the IL-36γ-induced mRNA expression of CXC chemokines (CXCL1, CXCL2, and CXCL8) in HT-29 and T84 cells. IL-38 inhibited the IL-36γ-induced activation of nuclear-factor kappa B (NF-κB) and mitogen-activated protein kinases in HT-29 cells. DSS-colitis was significantly exacerbated in IL-38KO mice compared to wild type mice. In conclusion, IL-38 may play an anti-inflammatory and protective role in the pathophysiology of IBD, in particular ulcerative colitis, through the suppression of IL-36-induced inflammatory responses. ","subitem_description_type":"Abstract"}]},"item_4_description_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Journal Article","subitem_description_type":"Other"}]},"item_4_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"The Society for Free Radical Research Japan"}]},"item_4_relation_10":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"35068683","subitem_relation_type_select":"PMID"}}]},"item_4_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"10.3164/jcbn.21-104"}],"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.3164/jcbn.21-104","subitem_relation_type_select":"DOI"}}]},"item_4_relation_13":{"attribute_name":"PMCID","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"PMC8764106"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.ncbi.nlm.nih.gov/pmc/articles/pmc8764106/","subitem_relation_type_select":"URI"}}]},"item_4_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2022 JCBN"}]},"item_4_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0912-0009","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"OHNO, Masashi"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"IMAI, Takayuki"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"CHATANI, Motoharu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"NISHIDA, Atsushi"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"INATOMI, Osamu"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"KAWAHARA, Masahiro"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"HOSHINO, Tomoaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"ANDOH, Akira"}],"nameIdentifiers":[{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-02-02"}],"displaytype":"detail","filename":"jcbn.21-104.pdf","filesize":[{"value":"3.4 MB"}],"format":"application/pdf","license_note":"This is an open access article distributed under the terms of the Creative \nCommons Attribution-NonCommercial-NoDerivatives License.\nhttps://creativecommons.org/licenses/by-nc-nd/4.0/","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"jcbn.21-104","url":"https://shiga-med.repo.nii.ac.jp/record/4107/files/jcbn.21-104.pdf"},"version_id":"d3559da5-9cf0-4f2b-be12-02468b8147a4"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-02-02"}],"displaytype":"detail","filename":"jcbn.21-104_Supplemental 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License.\nhttps://creativecommons.org/licenses/by-nc-nd/4.0/","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"jcbn.21-104_Supplemental Table2","url":"https://shiga-med.repo.nii.ac.jp/record/4107/files/jcbn.21-104_Supplemental Table2.pdf"},"version_id":"44016122-887f-4576-89fd-118232d4294a"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"inflammatory bowel disease","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"ulcerative colitis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"interleukin-38","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"interleukin-36","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal 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