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Cell-to-cell contact-mediated regulation of tumor behavior in the tumor microenvironment.
http://hdl.handle.net/10422/00013067
http://hdl.handle.net/10422/00013067a180d891-884c-45d4-85f0-a344906e0bd6
名前 / ファイル | ライセンス | アクション |
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cas.15114 (810.9 kB)
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This is an open access article under the terms of the Creat ive Commo ns Attri bution-NonCo mmercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2021-09-08 | |||||
タイトル | ||||||
タイトル | Cell-to-cell contact-mediated regulation of tumor behavior in the tumor microenvironment. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | intercellular communication | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | signal transduction | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | stroma | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | tumor invasion | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | tumor microenvironment | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
SATO, Akira
× SATO, Akira× RAHMAN, Nor Idayu A.× SHIMIZU, Akio× 扇田, 久和 |
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著者別名 |
佐藤, 朗
× 佐藤, 朗× 清水, 昭男× 扇田, 久和 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Tumor growth and progression are complex processes mediated by mutual interactions between cancer cells and their surrounding stroma that include diverse cell types and acellular components, which form the tumor microenvironment. In this environment, direct intercellular communications play important roles in the regulation of the biological behaviors of tumors. However, the underlying molecular mechanisms are insufficiently defined. We used an in vitro coculture system to identify genes that were specifically expressed at higher levels in cancer cells associated with stromal cells. Major examples included epithelial membrane protein 1 (EMP1) and stomatin, which positively and negatively regulate tumor progression, respectively. EMP1 promotes tumor cell migration and metastasis via activation of the small GTPase Rac1, while stomatin strongly suppresses cell proliferation and induces apoptosis of cancer cells via inhibition of Akt signaling. Here we highlight important aspects of EMP1, stomatin, and their family members in cancer biology. Furthermore, we consider the molecules that participate in intercellular communications and signaling transduction between cancer cells and stromal cells, which may affect the phenotypes of cancer cells in the tumor microenvironment. | |||||
書誌情報 |
en : Cancer science 発行日 2021-08-22 |
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出版者 | ||||||
出版者 | John Wiley and Sons Inc | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1349-7006 | |||||
PMID | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | 34420253 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1111/cas.15114 | |||||
関連名称 | 10.1111/cas.15114 | |||||
権利 | ||||||
権利情報 | © 2021 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association. | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | ||||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
資源タイプ | ||||||
内容記述タイプ | Other | |||||
内容記述 | Journal Article |