{"created":"2023-06-19T10:43:41.623398+00:00","id":3969,"links":{},"metadata":{"_buckets":{"deposit":"5db10d95-d5e3-4bd1-b799-6872843b797f"},"_deposit":{"created_by":11,"id":"3969","owners":[11],"pid":{"revision_id":0,"type":"depid","value":"3969"},"status":"published"},"_oai":{"id":"oai:shiga-med.repo.nii.ac.jp:00003969","sets":["30:89:90"]},"author_link":["6179","8527","7847","6731"],"item_4_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-08-22","bibliographicIssueDateType":"Issued"},"bibliographic_titles":[{},{"bibliographic_title":"Cancer science","bibliographic_titleLang":"en"}]}]},"item_4_creator_3":{"attribute_name":"著者別名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"佐藤, 朗"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"清水, 昭男"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"扇田, 久和"}],"nameIdentifiers":[{},{},{}]}]},"item_4_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"pdf","subitem_description_type":"Other"}]},"item_4_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Tumor growth and progression are complex processes mediated by mutual interactions between cancer cells and their surrounding stroma that include diverse cell types and acellular components, which form the tumor microenvironment. In this environment, direct intercellular communications play important roles in the regulation of the biological behaviors of tumors. However, the underlying molecular mechanisms are insufficiently defined. We used an in vitro coculture system to identify genes that were specifically expressed at higher levels in cancer cells associated with stromal cells. Major examples included epithelial membrane protein 1 (EMP1) and stomatin, which positively and negatively regulate tumor progression, respectively. EMP1 promotes tumor cell migration and metastasis via activation of the small GTPase Rac1, while stomatin strongly suppresses cell proliferation and induces apoptosis of cancer cells via inhibition of Akt signaling. Here we highlight important aspects of EMP1, stomatin, and their family members in cancer biology. Furthermore, we consider the molecules that participate in intercellular communications and signaling transduction between cancer cells and stromal cells, which may affect the phenotypes of cancer cells in the tumor microenvironment.","subitem_description_type":"Abstract"}]},"item_4_description_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Journal Article","subitem_description_type":"Other"}]},"item_4_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"John Wiley and Sons Inc"}]},"item_4_relation_10":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"34420253","subitem_relation_type_select":"PMID"}}]},"item_4_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"10.1111/cas.15114"}],"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1111/cas.15114","subitem_relation_type_select":"DOI"}}]},"item_4_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2021 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association. "}]},"item_4_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1349-7006","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"SATO, Akira"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"RAHMAN, Nor Idayu A."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"SHIMIZU, Akio"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"扇田, 久和"}],"nameIdentifiers":[{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-09-08"}],"displaytype":"detail","filename":"cas.15114.pdf","filesize":[{"value":"810.9 kB"}],"format":"application/pdf","license_note":"This is an open access article under the terms of the Creat ive Commo ns Attri bution-NonCo mmercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"cas.15114","url":"https://shiga-med.repo.nii.ac.jp/record/3969/files/cas.15114.pdf"},"version_id":"75ec4e37-8635-467a-bcbe-6387a9f256e0"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"intercellular communication","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"signal transduction","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"stroma","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"tumor invasion","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"tumor microenvironment","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Cell-to-cell contact-mediated regulation of tumor behavior in the tumor microenvironment.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Cell-to-cell contact-mediated regulation of tumor behavior in the tumor microenvironment."}]},"item_type_id":"4","owner":"11","path":["90"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-09-08"},"publish_date":"2021-09-08","publish_status":"0","recid":"3969","relation_version_is_last":true,"title":["Cell-to-cell contact-mediated regulation of tumor behavior in the tumor microenvironment."],"weko_creator_id":"11","weko_shared_id":-1},"updated":"2023-06-19T11:12:57.945478+00:00"}