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Malfunctioning CD106-positive, short-term hematopoietic stem cells trigger diabetic neuropathy in mice by cell fusion.
http://hdl.handle.net/10422/00012977
http://hdl.handle.net/10422/000129773aa894ba-da29-4b31-a99f-abc370b11e7f
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
s42003-021-02082-5 (4.5 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2021-05-26 | |||||
| タイトル | ||||||
| タイトル | Malfunctioning CD106-positive, short-term hematopoietic stem cells trigger diabetic neuropathy in mice by cell fusion. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Chronic inflammation | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Diabetes complications | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
KATAGI, Miwako
× KATAGI, Miwako× TERASHIMA, Tomoya× OHASHI, Natsuko× NAKAE, Yuki× YAMADA, Akane× NAKAGAWA, Takahiko× MIYAZAWA, Itsuko× MAEGAWA, Hiroshi× OKANO, Junko× SUZUKI, Yoshihisa× FUJINO, Kazunori× EGUCHI, Yutaka× KUSHIMA, Ryoji |
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| 著者別名 |
樫, 美和子
× 樫, 美和子× 寺島, 智也× 大橋, 夏子× 中江, 由希× 山田, 茜× 仲川, 孝彦× 宮澤, 伊都子× 前川, 聡× 岡野, 純子× 鈴木, 義久× 藤野, 和典× 江口, 豊× 小島, 秀人 |
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| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Diabetic neuropathy is an incurable disease. We previously identified a mechanism by which aberrant bone marrow-derived cells (BMDCs) pathologically expressing proinsulin/TNF-α fuse with residential neurons to impair neuronal function. Here, we show that CD106-positive cells represent a significant fraction of short-term hematopoietic stem cells (ST-HSCs) that contribute to the development of diabetic neuropathy in mice. The important role for these cells is supported by the fact that transplantation of either whole HSCs or CD106-positive ST-HSCs from diabetic mice to non-diabetic mice produces diabetic neuronal dysfunction in the recipient mice via cell fusion. Furthermore, we show that transient episodic hyperglycemia produced by glucose injections leads to abnormal fusion of pathological ST-HSCs with residential neurons, reproducing neuropathy in nondiabetic mice. In conclusion, we have identified hyperglycemia-induced aberrant CD106-positive ST-HSCs underlie the development of diabetic neuropathy. Aberrant CD106-positive ST-HSCs constitute a novel therapeutic target for the treatment of diabetic neuropathy. | |||||
| 書誌情報 |
en : Communications Biology 巻 4, 号 1, 発行日 2021-05-21 |
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| 出版者 | ||||||
| 出版者 | Springer Nature | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 23993642 | |||||
| PMID | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 33990693 | |||||
| PMCID | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.ncbi.nlm.nih.gov/pmc/articles/pmc8121918/ | |||||
| 関連名称 | PMC8121918 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1038/s42003-021-02082-5 | |||||
| 関連名称 | 10.1038/s42003-021-02082-5 | |||||
| 権利 | ||||||
| 権利情報 | © The Author(s) 2021 | |||||
| フォーマット | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | ||||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Journal Article | |||||
