{"created":"2023-06-19T10:43:36.885771+00:00","id":3867,"links":{},"metadata":{"_buckets":{"deposit":"6c0f51da-8735-4a33-813d-665e9d18e26f"},"_deposit":{"created_by":11,"id":"3867","owners":[11],"pid":{"revision_id":0,"type":"depid","value":"3867"},"status":"published"},"_oai":{"id":"oai:shiga-med.repo.nii.ac.jp:00003867","sets":["30:202:203","30:289:290","30:403:404","30:59:221"]},"author_link":["2849","3394","7211","534","547","12","531","550","7358","553","538","7208","7179","8522"],"item_4_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-05-21","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicVolumeNumber":"4","bibliographic_titles":[{},{"bibliographic_title":"Communications Biology","bibliographic_titleLang":"en"}]}]},"item_4_creator_3":{"attribute_name":"著者別名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"樫, 美和子"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"寺島, 智也"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"大橋, 夏子"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"中江, 由希"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"山田, 茜"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"仲川, 孝彦"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"宮澤, 伊都子"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"前川, 聡"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"岡野, 純子"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"鈴木, 義久"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"藤野, 和典"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"江口, 豊"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"小島, 秀人"}],"nameIdentifiers":[{},{},{}]}]},"item_4_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"pdf","subitem_description_type":"Other"}]},"item_4_description_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Journal Article","subitem_description_type":"Other"}]},"item_4_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Diabetic neuropathy is an incurable disease. We previously identified a mechanism by which aberrant bone marrow-derived cells (BMDCs) pathologically expressing proinsulin/TNF-α fuse with residential neurons to impair neuronal function. Here, we show that CD106-positive cells represent a significant fraction of short-term hematopoietic stem cells (ST-HSCs) that contribute to the development of diabetic neuropathy in mice. The important role for these cells is supported by the fact that transplantation of either whole HSCs or CD106-positive ST-HSCs from diabetic mice to non-diabetic mice produces diabetic neuronal dysfunction in the recipient mice via cell fusion. Furthermore, we show that transient episodic hyperglycemia produced by glucose injections leads to abnormal fusion of pathological ST-HSCs with residential neurons, reproducing neuropathy in nondiabetic mice. In conclusion, we have identified hyperglycemia-induced aberrant CD106-positive ST-HSCs underlie the development of diabetic neuropathy. Aberrant CD106-positive ST-HSCs constitute a novel therapeutic target for the treatment of diabetic neuropathy. ","subitem_description_type":"Other"}]},"item_4_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer Nature"}]},"item_4_relation_10":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"33990693","subitem_relation_type_select":"PMID"}}]},"item_4_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"10.1038/s42003-021-02082-5"}],"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1038/s42003-021-02082-5","subitem_relation_type_select":"DOI"}}]},"item_4_relation_13":{"attribute_name":"PMCID","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"PMC8121918"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.ncbi.nlm.nih.gov/pmc/articles/pmc8121918/","subitem_relation_type_select":"URI"}}]},"item_4_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© The Author(s) 2021"}]},"item_4_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"23993642","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"KATAGI, Miwako"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"TERASHIMA, Tomoya"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"OHASHI, Natsuko"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"NAKAE, Yuki"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"YAMADA, Akane"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"NAKAGAWA, Takahiko"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"MIYAZAWA, Itsuko"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"MAEGAWA, Hiroshi"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"OKANO, Junko"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"SUZUKI, Yoshihisa"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"FUJINO, Kazunori"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"EGUCHI, Yutaka"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"KUSHIMA, Ryoji"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-05-26"}],"displaytype":"detail","filename":"s42003-021-02082-5.pdf","filesize":[{"value":"4.5 MB"}],"format":"application/pdf","license_note":"This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit\nhttp://creativecommons.org/licenses/by/4.0/.","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"s42003-021-02082-5","url":"https://shiga-med.repo.nii.ac.jp/record/3867/files/s42003-021-02082-5.pdf"},"version_id":"b124cc71-2c05-4a72-8b8d-2fb321334455"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Chronic inflammation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Diabetes complications","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Malfunctioning CD106-positive, short-term hematopoietic stem cells trigger diabetic neuropathy in mice by cell fusion.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Malfunctioning CD106-positive, short-term hematopoietic stem cells trigger diabetic neuropathy in mice by cell fusion."}]},"item_type_id":"4","owner":"11","path":["203","221","290","404"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-05-26"},"publish_date":"2021-05-26","publish_status":"0","recid":"3867","relation_version_is_last":true,"title":["Malfunctioning CD106-positive, short-term hematopoietic stem cells trigger diabetic neuropathy in mice by cell fusion."],"weko_creator_id":"11","weko_shared_id":-1},"updated":"2023-06-19T11:31:58.802752+00:00"}