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Gm14230 controls Tbc1d24 cytoophidia and neuronal cellular juvenescence.
http://hdl.handle.net/10422/00012970
http://hdl.handle.net/10422/00012970c82f4cd0-07d8-4f4d-b16c-71db1b53e6b8
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
journal.pone.0248517 (2.6 MB)
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This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2021-05-13 | |||||
| タイトル | ||||||
| タイトル | Gm14230 controls Tbc1d24 cytoophidia and neuronal cellular juvenescence. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
MORIMUNE, Takao
× MORIMUNE, Takao× TANO, Ayami× TANAKA, Yuya× YUKIUE, Haruka× YAMAMOTO, Takefumi× TOOYAMA, Ikuo× MARUO, Yoshihiro× NISHIMURA, Masaki× MORI, Masaki |
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| 著者別名 |
森宗, 孝夫
× 森宗, 孝夫× 田埜, 郁実× 田中, 雄也× 雪上, 晴加× 山元, 武文× 遠山, 育夫× 丸尾, 良浩× 西村, 正樹× 森, 雅樹 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | It is not fully understood how enzymes are regulated in the tiny reaction field of a cell. Several enzymatic proteins form cytoophidia, a cellular macrostructure to titrate enzymatic activities. Here, we show that the epileptic encephalopathy-associated protein Tbc1d24 forms cytoophidia in neuronal cells both in vitro and in vivo. The Tbc1d24 cytoophidia are distinct from previously reported cytoophidia consisting of inosine monophosphate dehydrogenase (Impdh) or cytidine-5'-triphosphate synthase (Ctps). Tbc1d24 cytoophidia is induced by loss of cellular juvenescence caused by depletion of Gm14230, a juvenility-associated lncRNA (JALNC) and zeocin treatment. Cytoophidia formation is associated with impaired enzymatic activity of Tbc1d24. Thus, our findings reveal the property of Tbc1d24 to form cytoophidia to maintain neuronal cellular juvenescence. | |||||
| 書誌情報 |
en : PLoS ONE 巻 16, 号 4, 発行日 2021-04-22 |
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| 出版者 | ||||||
| 出版者 | Public Library of Science | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 19326203 | |||||
| PMID | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 33886577 | |||||
| PMCID | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.ncbi.nlm.nih.gov/pmc/articles/pmc8062039/ | |||||
| 関連名称 | PMC8062039 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1371/journal.pone.0248517 | |||||
| 関連名称 | 10.1371/journal.pone.0248517 | |||||
| 権利 | ||||||
| 権利情報 | © 2021 Morimune et al. | |||||
| フォーマット | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | ||||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Journal Article | |||||
