{"created":"2023-06-19T10:43:36.621471+00:00","id":3860,"links":{},"metadata":{"_buckets":{"deposit":"78f40012-9812-4b66-898e-95c84562410b"},"_deposit":{"created_by":11,"id":"3860","owners":[11],"pid":{"revision_id":0,"type":"depid","value":"3860"},"status":"published"},"_oai":{"id":"oai:shiga-med.repo.nii.ac.jp:00003860","sets":["19:219:220","19:232:233","30:68:267"]},"author_link":["8243","7488","7491","2545","1957","7826","7600","2869","7493"],"item_4_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-04-22","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicVolumeNumber":"16","bibliographic_titles":[{},{"bibliographic_title":"PLoS ONE","bibliographic_titleLang":"en"}]}]},"item_4_creator_3":{"attribute_name":"著者別名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"森宗, 孝夫"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"田埜, 郁実"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"田中, 雄也"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"雪上, 晴加"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"山元, 武文"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"遠山, 育夫"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"丸尾, 良浩"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"西村, 正樹"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"森, 雅樹"}],"nameIdentifiers":[{},{},{}]}]},"item_4_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"pdf","subitem_description_type":"Other"}]},"item_4_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"It is not fully understood how enzymes are regulated in the tiny reaction field of a cell. Several enzymatic proteins form cytoophidia, a cellular macrostructure to titrate enzymatic activities. Here, we show that the epileptic encephalopathy-associated protein Tbc1d24 forms cytoophidia in neuronal cells both in vitro and in vivo. The Tbc1d24 cytoophidia are distinct from previously reported cytoophidia consisting of inosine monophosphate dehydrogenase (Impdh) or cytidine-5'-triphosphate synthase (Ctps). Tbc1d24 cytoophidia is induced by loss of cellular juvenescence caused by depletion of Gm14230, a juvenility-associated lncRNA (JALNC) and zeocin treatment. Cytoophidia formation is associated with impaired enzymatic activity of Tbc1d24. Thus, our findings reveal the property of Tbc1d24 to form cytoophidia to maintain neuronal cellular juvenescence. ","subitem_description_type":"Abstract"}]},"item_4_description_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Journal Article","subitem_description_type":"Other"}]},"item_4_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Public Library of Science"}]},"item_4_relation_10":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"33886577","subitem_relation_type_select":"PMID"}}]},"item_4_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"10.1371/journal.pone.0248517"}],"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1371/journal.pone.0248517","subitem_relation_type_select":"DOI"}}]},"item_4_relation_13":{"attribute_name":"PMCID","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"PMC8062039"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.ncbi.nlm.nih.gov/pmc/articles/pmc8062039/","subitem_relation_type_select":"URI"}}]},"item_4_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2021 Morimune et al. "}]},"item_4_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"19326203","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"MORIMUNE, Takao"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"TANO, Ayami"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"TANAKA, Yuya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"YUKIUE, Haruka"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"YAMAMOTO, Takefumi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"TOOYAMA, Ikuo"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"MARUO, Yoshihiro"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"NISHIMURA, Masaki"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"MORI, Masaki"}],"nameIdentifiers":[{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-05-13"}],"displaytype":"detail","filename":"journal.pone.0248517.pdf","filesize":[{"value":"2.6 MB"}],"format":"application/pdf","license_note":"This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"journal.pone.0248517","url":"https://shiga-med.repo.nii.ac.jp/record/3860/files/journal.pone.0248517.pdf"},"version_id":"acadb45c-c0fc-461c-8721-370b2e9ed840"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Gm14230 controls Tbc1d24 cytoophidia and neuronal cellular juvenescence.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Gm14230 controls Tbc1d24 cytoophidia and neuronal cellular juvenescence."}]},"item_type_id":"4","owner":"11","path":["220","233","267"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-05-13"},"publish_date":"2021-05-13","publish_status":"0","recid":"3860","relation_version_is_last":true,"title":["Gm14230 controls Tbc1d24 cytoophidia and neuronal cellular juvenescence."],"weko_creator_id":"11","weko_shared_id":-1},"updated":"2023-06-19T11:34:27.304374+00:00"}