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Life-Long Neural Stem Cells Are Fate-Specified at an Early Developmental Stage.
http://hdl.handle.net/10422/00012859
http://hdl.handle.net/10422/00012859d94fe2d3-7428-4430-963e-ba31005ec43d
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2020-11-25 | |||||
| タイトル | ||||||
| タイトル | Life-Long Neural Stem Cells Are Fate-Specified at an Early Developmental Stage. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | barcoding | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | clonal analysis | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | lentivirus | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | mouse neural stem cells | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | neurospheres. | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
TANAKA, Aoi
× TANAKA, Aoi× ISHIDA, Shohei× FUCHIGAMI, Takahiro× HAYASHI, Yoshitaka× Kuroda, Anri× IKENAKA, Kazuhiro× FUKAZAWA, Yugo× HITOSHI, Seiji |
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| 著者別名 |
田中, 葵
× 田中, 葵× 石田, 正平× 渕上, 孝裕× 林, 義剛× 等, 誠司 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The origin and life-long fate of quiescent neural stem cells (NSCs) in the adult mammalian brain remain largely unknown. A few neural precursor cells in the embryonic brain elongate their cell cycle time and subsequently become quiescent postnatally, suggesting the possibility that life-long NSCs are selected at an early embryonic stage. Here, we utilized a GFP-expressing lentivirus to investigate the fate of progeny from individual lentivirus-infected NSCs by identifying the lentiviral integration site. Our data suggest that NSCs become specified to two or more lineages prior to embryonic day 13.5 in mice: one NSC lineage produces cells only for the cortex and another provides neurons to the olfactory bulb. The majority of neurosphere-forming NSCs in the adult brain are relatively dormant and generate very few cells, if any, in the olfactory bulb or cortex, and this NSC population could serve as a reservoir that is occasionally reactivated later in life. | |||||
| 書誌情報 |
en : Cerebral cortex (New York, N.Y. : 1991) 巻 30, 号 12, p. 6415-6425, 発行日 2020-11-03 |
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| 出版者 | ||||||
| 出版者 | Oxford University Press | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1460-2199 | |||||
| PMID | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 32766673 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1093/cercor/bhaa200 | |||||
| 関連名称 | 10.1093/cercor/bhaa200 | |||||
| 権利 | ||||||
| 権利情報 | © The Author(s) 2020. Published by Oxford University Press. All rights reserved. | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Journal Article | |||||
