{"created":"2023-06-19T10:43:30.802289+00:00","id":3747,"links":{},"metadata":{"_buckets":{"deposit":"7f1ae750-8176-46ce-8f31-15f4c9942b19"},"_deposit":{"created_by":11,"id":"3747","owners":[11],"pid":{"revision_id":0,"type":"depid","value":"3747"},"status":"published"},"_oai":{"id":"oai:shiga-med.repo.nii.ac.jp:00003747","sets":["30:250:251"]},"author_link":["7769","5888","6403","8267","7771","8269","8268","7937"],"item_4_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-11-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"12","bibliographicPageEnd":"6425","bibliographicPageStart":"6415","bibliographicVolumeNumber":"30","bibliographic_titles":[{},{"bibliographic_title":"Cerebral cortex (New York, N.Y. : 1991)","bibliographic_titleLang":"en"}]}]},"item_4_creator_3":{"attribute_name":"著者別名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"田中, 葵"}],"nameIdentifiers":[{"nameIdentifier":"8267","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"石田, 正平"}],"nameIdentifiers":[{"nameIdentifier":"8268","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"渕上, 孝裕"}],"nameIdentifiers":[{"nameIdentifier":"7769","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"林, 義剛"}],"nameIdentifiers":[{"nameIdentifier":"6403","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"10631567","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=10631567"}]},{"creatorNames":[{"creatorName":"等, 誠司"}],"nameIdentifiers":[{"nameIdentifier":"5888","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"70300895","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=70300895"},{"nameIdentifier":"0000-0002-6339-6802","nameIdentifierScheme":"ORCID","nameIdentifierURI":"https://orcid.org/0000-0002-6339-6802"}]}]},"item_4_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The origin and life-long fate of quiescent neural stem cells (NSCs) in the adult mammalian brain remain largely unknown. A few neural precursor cells in the embryonic brain elongate their cell cycle time and subsequently become quiescent postnatally, suggesting the possibility that life-long NSCs are selected at an early embryonic stage. Here, we utilized a GFP-expressing lentivirus to investigate the fate of progeny from individual lentivirus-infected NSCs by identifying the lentiviral integration site. Our data suggest that NSCs become specified to two or more lineages prior to embryonic day 13.5 in mice: one NSC lineage produces cells only for the cortex and another provides neurons to the olfactory bulb. The majority of neurosphere-forming NSCs in the adult brain are relatively dormant and generate very few cells, if any, in the olfactory bulb or cortex, and this NSC population could serve as a reservoir that is occasionally reactivated later in life.","subitem_description_type":"Abstract"}]},"item_4_description_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Journal Article","subitem_description_type":"Other"}]},"item_4_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Oxford University Press"}]},"item_4_relation_10":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"32766673","subitem_relation_type_select":"PMID"}}]},"item_4_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"10.1093/cercor/bhaa200"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1093/cercor/bhaa200","subitem_relation_type_select":"DOI"}}]},"item_4_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© The Author(s) 2020. Published by Oxford University Press. All rights reserved. "}]},"item_4_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1460-2199","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"TANAKA, Aoi"}],"nameIdentifiers":[{"nameIdentifier":"8267","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"ISHIDA, Shohei"}],"nameIdentifiers":[{"nameIdentifier":"8268","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"FUCHIGAMI, Takahiro"}],"nameIdentifiers":[{"nameIdentifier":"7769","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"HAYASHI, Yoshitaka"}],"nameIdentifiers":[{"nameIdentifier":"6403","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"10631567","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=10631567"}]},{"creatorNames":[{"creatorName":"Kuroda, Anri"}],"nameIdentifiers":[{"nameIdentifier":"7937","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"IKENAKA, Kazuhiro"}],"nameIdentifiers":[{"nameIdentifier":"7771","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"FUKAZAWA, Yugo"}],"nameIdentifiers":[{"nameIdentifier":"8269","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"HITOSHI, Seiji"}],"nameIdentifiers":[{"nameIdentifier":"5888","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"70300895","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=70300895"},{"nameIdentifier":"0000-0002-6339-6802","nameIdentifierScheme":"ORCID","nameIdentifierURI":"https://orcid.org/0000-0002-6339-6802"}]}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"barcoding","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"clonal analysis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"lentivirus","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"mouse neural stem cells","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"neurospheres.","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Life-Long Neural Stem Cells Are Fate-Specified at an Early Developmental Stage.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Life-Long Neural Stem Cells Are Fate-Specified at an Early Developmental Stage."}]},"item_type_id":"4","owner":"11","path":["251"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-11-25"},"publish_date":"2020-11-25","publish_status":"0","recid":"3747","relation_version_is_last":true,"title":["Life-Long Neural Stem Cells Are Fate-Specified at an Early Developmental Stage."],"weko_creator_id":"11","weko_shared_id":-1},"updated":"2023-06-19T11:41:40.660705+00:00"}