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Neuroepithelial cell competition triggers loss of cellular juvenescence.
http://hdl.handle.net/10422/00012833
http://hdl.handle.net/10422/00012833e71db65c-fe01-46f4-bee9-0ef58d65a601
| 名前 / ファイル | ライセンス | アクション |
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s41598-020-74874-4 (3.5 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2020-11-06 | |||||
| タイトル | ||||||
| タイトル | Neuroepithelial cell competition triggers loss of cellular juvenescence. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Cell biology | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Cell proliferation | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Jam, Faidruz Azura Binti
× Jam, Faidruz Azura Binti× Morimune, Takao× TSUKAMURA, Atsushi× Tano, Ayami× TANAKA, Yuya× MORI, Yasuhiro× YAMAMOTO, Takefumi× NISHIMURA, Masaki× TOOYAMA, Ikuo× MORI, Masaki |
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| 著者別名 |
森宗, 孝夫
× 森宗, 孝夫× 塚村, 篤史× 田埜, 郁実× 田中, 雄也× 森, 康博× 山元, 武文× 西村, 正樹× 遠山, 育夫× 森, 雅樹 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Cell competition is a cell-cell interaction mechanism which maintains tissue homeostasis through selective elimination of unfit cells. During early brain development, cells are eliminated through apoptosis. How cells are selected to undergo elimination remains unclear. Here we aimed to identify a role for cell competition in the elimination of suboptimal cells using an in vitro neuroepithelial model. Cell competition was observed when neural progenitor HypoE-N1 cells expressing RASV12 were surrounded by normal cells in the co-culture. The elimination through apoptosis was observed by cellular changes of RASV12 cells with rounding/fragmented morphology, by SYTOX blue-positivity, and by expression of apoptotic markers active caspase-3 and cleaved PARP. In this model, expression of juvenility-associated genes Srsf7 and Ezh2 were suppressed under cell-competitive conditions. Srsf7 depletion led to loss of cellular juvenescence characterized by suppression of Ezh2, cell growth impairment and enhancement of senescence-associated proteins. The cell bodies of eliminated cells were engulfed by the surrounding cells through phagocytosis. Our data indicates that neuroepithelial cell competition may have an important role for maintaining homeostasis in the neuroepithelium by eliminating suboptimal cells through loss of cellular juvenescence. | |||||
| 書誌情報 |
en : Scientific Reports 巻 10, 号 1, p. 18044, 発行日 2020-10-22 |
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| 出版者 | ||||||
| 出版者 | Nature Research | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 20452322 | |||||
| PMID | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 33093561 | |||||
| PMCID | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.ncbi.nlm.nih.gov/pmc/articles/pmc7582913/ | |||||
| 関連名称 | PMC7582913 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1038/s41598-020-74874-4 | |||||
| 関連名称 | 10.1038/s41598-020-74874-4 | |||||
| 権利 | ||||||
| 権利情報 | © The Author(s) 2020 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Journal Article | |||||
