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A genome-wide association study on fish consumption in a Japanese population-the Japan Multi-Institutional Collaborative Cohort study.
http://hdl.handle.net/10422/00012803
http://hdl.handle.net/10422/00012803d8d083d0-8b9e-4ec4-b9aa-e31ad10e175d
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2020-09-24 | |||||
| タイトル | ||||||
| タイトル | A genome-wide association study on fish consumption in a Japanese population-the Japan Multi-Institutional Collaborative Cohort study. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
SUZUKI, Taro
× SUZUKI, Taro× NAKAMURA, Yasuyuki× Matsuo, Keitaro× OZE, Isao× DOIDA, Yukio× NARITA, Akira× SHIMIZU, Atsushi× IMAEDA, Nahomi× GOTO, Chiho× MATSUI, Kenji× NAKATOCHI, Masahiro× MIURA, Katsuyuki× TAKASHIMA, Naoyuki× KURIKI, Kiyonori× SHIMANOE, Chisato× TANAKA, Keitaro× IKEZAKI, Hiroaki× MURATA, Masayuki× IBUSUKI, Rie× TAKEZAKI, Toshiro× KOYANAGI, Yuriko× ITO, Hidemi× MATSUI, Daisuke× KOYAMA, Teruhide× MIKAMI, Haruo× NAKAMURA, Yohko× SUZUKI, Sadao× NISHIYAMA, takeshi× KATSUURA-KAMANO, Sakurako× ARISAWA, Kokichi× TAKEUCHI, Kenji× TAMURA, Takashi× OKADA, Rieko× KUBO, Yoko× Momozawa, Yukihide× Kubo, Michiaki× KITA, Yoshikuni× WAKAI, Kenji× J-MICC Research Group |
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| 著者別名 |
中村, 保幸
× 中村, 保幸× 三浦, 克之× 高嶋, 直敬× 喜多, 義邦 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Background/Objective: Although benefits of fish consumption for health are well known, a significant percentage of individuals dislike eating fish. Fish consumption may be influenced by genetic factors in addition to environmental factors. We conducted a genome-wide association study (GWAS) to find genetic variations that affect fish consumption in a Japanese population. |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Methods: We performed a two-stage GWAS on fish consumption using 13,739 discovery samples from the Japan Multi-Institutional Collaborative Cohort study, and 2845 replication samples from the other population. We used a semi-quantitative food frequency questionnaire to estimate food intake. Association of the imputed variants with fish consumption was analyzed by separate linear regression models per variant, with adjustments for age, sex, energy intake, principal component analysis components 1-10, and alcohol intake (g/day). We also performed conditional analysis. |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Results: We found 27 single nucleotide polymorphisms (SNPs) located in 12q24 and 14q32.12 that were associated with fish consumption. The 19 SNPs were located at 11 genes including six lead SNPs at the BRAP, ACAD10, ALDH2, NAA25, and HECTD4 regions on 12q24.12-13, and CCDC197 region on 14q32.12. In replication samples, all five SNPs located on chromosome 12 were replicated successfully, but the one on chromosome 14 was not. Conditional analyses revealed that the five lead variants in chromosome 12 were in fact the same signal. |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Conclusion: We found that new SNPs in the 12q24 locus were related to fish intake in two Japanese populations. The associations between SNPs on chromosome 12 and fish intake were strongly confounded by drinking status. |
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| 書誌情報 |
en : European journal of clinical nutrition 発行日 2020-09-07 |
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| 出版者 | ||||||
| 出版者 | Springer Nature | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1476-5640 | |||||
| PMID | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 32895509 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1038/s41430-020-00702-7 | |||||
| 関連名称 | 10.1038/s41430-020-00702-7 | |||||
| 権利 | ||||||
| 権利情報 | © The Author(s), under exclusive licence to Springer Nature Limited 2020 | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Journal Article | |||||
