@article{oai:shiga-med.repo.nii.ac.jp:00003689,
 author = {中村, 保幸 and 三浦, 克之 and 高嶋, 直敬 and 喜多, 義邦 and SUZUKI, Taro and NAKAMURA, Yasuyuki and Matsuo, Keitaro and OZE, Isao and DOIDA, Yukio and NARITA, Akira and SHIMIZU, Atsushi and IMAEDA, Nahomi and GOTO, Chiho and MATSUI, Kenji and NAKATOCHI, Masahiro and MIURA, Katsuyuki and TAKASHIMA, Naoyuki and KURIKI, Kiyonori and SHIMANOE, Chisato and TANAKA, Keitaro and IKEZAKI, Hiroaki and MURATA, Masayuki and IBUSUKI, Rie and TAKEZAKI, Toshiro and KOYANAGI, Yuriko and ITO, Hidemi and MATSUI, Daisuke and KOYAMA, Teruhide and MIKAMI, Haruo and NAKAMURA, Yohko and SUZUKI, Sadao and NISHIYAMA, takeshi and KATSUURA-KAMANO, Sakurako and ARISAWA, Kokichi and TAKEUCHI, Kenji and TAMURA, Takashi and OKADA, Rieko and KUBO, Yoko and Momozawa, Yukihide and Kubo, Michiaki and KITA, Yoshikuni and WAKAI, Kenji and J-MICC Research Group},
 journal = {European journal of clinical nutrition},
 month = {Sep},
 note = {Background/Objective:
Although benefits of fish consumption for health are well known, a significant percentage of individuals dislike eating fish. Fish consumption may be influenced by genetic factors in addition to environmental factors. We conducted a genome-wide association study (GWAS) to find genetic variations that affect fish consumption in a Japanese population., Methods:
We performed a two-stage GWAS on fish consumption using 13,739 discovery samples from the Japan Multi-Institutional Collaborative Cohort study, and 2845 replication samples from the other population. We used a semi-quantitative food frequency questionnaire to estimate food intake. Association of the imputed variants with fish consumption was analyzed by separate linear regression models per variant, with adjustments for age, sex, energy intake, principal component analysis components 1-10, and alcohol intake (g/day). We also performed conditional analysis., Results:
We found 27 single nucleotide polymorphisms (SNPs) located in 12q24 and 14q32.12 that were associated with fish consumption. The 19 SNPs were located at 11 genes including six lead SNPs at the BRAP, ACAD10, ALDH2, NAA25, and HECTD4 regions on 12q24.12-13, and CCDC197 region on 14q32.12. In replication samples, all five SNPs located on chromosome 12 were replicated successfully, but the one on chromosome 14 was not. Conditional analyses revealed that the five lead variants in chromosome 12 were in fact the same signal., Conclusion:
We found that new SNPs in the 12q24 locus were related to fish intake in two Japanese populations. The associations between SNPs on chromosome 12 and fish intake were strongly confounded by drinking status., Journal Article},
 title = {A genome-wide association study on fish consumption in a Japanese population-the Japan Multi-Institutional Collaborative Cohort study.},
 year = {2020}
}