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Respirovirus C protein inhibits activation of type I interferon receptor-associated kinases to block JAK-STAT signaling.
http://hdl.handle.net/10422/00012605
http://hdl.handle.net/10422/00012605cad2af85-03db-4ef8-be39-3de3b3646850
名前 / ファイル | ライセンス | アクション |
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1873-3468.13670 (3.2 MB)
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© 2019 Federation of European Biochemical Societies.
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2020-01-08 | |||||
タイトル | ||||||
タイトル | Respirovirus C protein inhibits activation of type I interferon receptor-associated kinases to block JAK-STAT signaling. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | C protein | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | JAK-STAT pathway | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | JAK1 | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Sendai virus | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | TYK2 | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | interferon | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | respirovirus | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
KITAGAWA, Yoshinori
× KITAGAWA, Yoshinori× YAMAGUCHI, Mayu× KOHNO, Miki× SAKAI, Madoka× ITOH, Masae× GOTOH, Bin |
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著者別名 |
北川, 善紀
× 北川, 善紀× 後藤, 敏 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Respirovirus C protein blocks the type I interferon (IFN)-stimulated activation of the JAK-STAT pathway. It has been reported that C protein inhibits IFN-α-stimulated tyrosine phosphorylation of STATs, but the underlying mechanism is poorly understood. Here, we show that the C protein of Sendai virus (SeV), a member of the Respirovirus genus, binds to the IFN receptor subunit IFN-α/β receptor subunit (IFNAR)2 and inhibits IFN-α-stimulated tyrosine phosphorylation of the upstream receptor-associated kinases, JAK1 and TYK2. Analysis of various SeV C mutant (Cm) proteins demonstrates the importance of the inhibitory effect on receptor-associated kinase phosphorylation for blockade of JAK-STAT signaling. Furthermore, this inhibitory effect and the IFNAR2 binding capacity are observed for all the respirovirus C proteins examined. Our results suggest that respirovirus C protein inhibits activation of the receptor-associated kinases JAK1 and TYK2 possibly through interaction with IFNAR2. | |||||
書誌情報 |
en : FEBS letters 発行日 2019-11-09 |
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出版者 | ||||||
出版者 | John Wiley & Sons Ltd. | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1873-3468 | |||||
PMID | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | PMID | |||||
関連識別子 | 31705658 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1002/1873-3468.13670 | |||||
関連名称 | 10.1002/1873-3468.13670 | |||||
権利 | ||||||
権利情報 | © 2019 Federation of European Biochemical Societies | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
資源タイプ | ||||||
内容記述タイプ | Other | |||||
内容記述 | Journal Article |