{"created":"2023-06-19T10:43:16.547338+00:00","id":3482,"links":{},"metadata":{"_buckets":{"deposit":"0e56b3fe-54cd-4a7f-b4a7-1c69eb9b0b80"},"_deposit":{"created_by":11,"id":"3482","owners":[11],"pid":{"revision_id":0,"type":"depid","value":"3482"},"status":"published"},"_oai":{"id":"oai:shiga-med.repo.nii.ac.jp:00003482","sets":["30:234:235"]},"author_link":["7678","3737","701","7677","7676","6101"],"item_4_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-11-09","bibliographicIssueDateType":"Issued"},"bibliographic_titles":[{},{"bibliographic_title":"FEBS letters","bibliographic_titleLang":"en"}]}]},"item_4_creator_3":{"attribute_name":"著者別名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"北川, 善紀"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"後藤, 敏"}],"nameIdentifiers":[{},{}]}]},"item_4_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Respirovirus C protein blocks the type I interferon (IFN)-stimulated activation of the JAK-STAT pathway. It has been reported that C protein inhibits IFN-α-stimulated tyrosine phosphorylation of STATs, but the underlying mechanism is poorly understood. Here, we show that the C protein of Sendai virus (SeV), a member of the Respirovirus genus, binds to the IFN receptor subunit IFN-α/β receptor subunit (IFNAR)2 and inhibits IFN-α-stimulated tyrosine phosphorylation of the upstream receptor-associated kinases, JAK1 and TYK2. Analysis of various SeV C mutant (Cm) proteins demonstrates the importance of the inhibitory effect on receptor-associated kinase phosphorylation for blockade of JAK-STAT signaling. Furthermore, this inhibitory effect and the IFNAR2 binding capacity are observed for all the respirovirus C proteins examined. Our results suggest that respirovirus C protein inhibits activation of the receptor-associated kinases JAK1 and TYK2 possibly through interaction with IFNAR2.","subitem_description_type":"Abstract"}]},"item_4_description_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Journal Article","subitem_description_type":"Other"}]},"item_4_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"John Wiley & Sons Ltd."}]},"item_4_relation_10":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"31705658","subitem_relation_type_select":"PMID"}}]},"item_4_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"10.1002/1873-3468.13670"}],"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1002/1873-3468.13670","subitem_relation_type_select":"DOI"}}]},"item_4_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2019 Federation of European Biochemical Societies"}]},"item_4_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1873-3468","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"KITAGAWA, Yoshinori"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"YAMAGUCHI, Mayu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"KOHNO, Miki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"SAKAI, Madoka"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"ITOH, Masae"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"GOTOH, Bin"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-11-09"}],"displaytype":"detail","filename":"1873-3468.13670.pdf","filesize":[{"value":"3.2 MB"}],"format":"application/pdf","license_note":"© 2019 Federation of European Biochemical Societies.","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"1873-3468.13670","url":"https://shiga-med.repo.nii.ac.jp/record/3482/files/1873-3468.13670.pdf"},"version_id":"46bf25cd-4668-471f-8782-7a7c767b537e"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"C protein","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"JAK-STAT pathway","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"JAK1","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Sendai virus","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"TYK2","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"interferon","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"respirovirus","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Respirovirus C protein inhibits activation of type I interferon receptor-associated kinases to block JAK-STAT signaling.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Respirovirus C protein inhibits activation of type I interferon receptor-associated kinases to block JAK-STAT signaling."}]},"item_type_id":"4","owner":"11","path":["235"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-01-08"},"publish_date":"2020-01-08","publish_status":"0","recid":"3482","relation_version_is_last":true,"title":["Respirovirus C protein inhibits activation of type I interferon receptor-associated kinases to block JAK-STAT signaling."],"weko_creator_id":"11","weko_shared_id":-1},"updated":"2023-06-19T12:23:30.602796+00:00"}