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Progression Potential of Ductal Carcinoma in situ Assessed by Genomic Copy Number Profiling.
http://hdl.handle.net/10422/00012482
http://hdl.handle.net/10422/000124826b1febdb-d2f0-488f-b37e-d58c076f5c80
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
10.1159000492833 (1.3 MB)
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All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2019-02-22 | |||||
| タイトル | ||||||
| タイトル | Progression Potential of Ductal Carcinoma in situ Assessed by Genomic Copy Number Profiling. | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Copy number alterations | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Array-based comparative genomic hybridization | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Breast cancer | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Ductal carcinoma in situ | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Unsupervised hierarchical clustering | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 著者 |
KITAMURA, Mina
× KITAMURA, Mina× NAKAYAMA, Takahisa× MUKAISHO, Ken-ichi× MORI, Tsuyoshi× UMEDA, Tomoko× Moritani, Suzuko× KUSHIMA, Ryoji× TANI, Masaji× SUGIHARA, Hiroyuki |
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| 著者別名 |
北村, 美奈
× 北村, 美奈× 仲山, 貴永× 向所, 賢一× 森, 毅× 梅田, 朋子× 森谷, 鈴子× 九嶋, 亮治× 谷, 眞至× 杉原, 洋行 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | BACKGROUND:Ductal carcinoma in situ (DCIS) of the breast is heterogeneous in terms of the risk of progression to invasive ductal carcinoma (IDC). To treat DCIS appropriately for its progression risk, we classified individual DCIS by its profile of genomic changes into 2 groups and correlated them with clinicopathological progression factors. METHODS:We used surgically resected, formalin-fixed, paraffin-embedded tissues of 22 DCIS and 30 IDC lesions. We performed immunohistochemical intrinsic subtyping, array-based comparative genomic hybridization, and unsupervised clustering. RESULTS:The samples were divided into 2 major clusters, A and B. Cluster A showed a greater number of gene and chromosome copy number alterations, a larger IDC/DCIS ratio, a higher frequency of nonluminal subtype, a lower frequency of luminal subtype, and a higher nuclear grade, when compared with cluster B. However, there was no difference in the frequencies of lymph node metastasis between clusters A and B. We identified 9 breast-cancer-related genes, including TP53 and GATA3, that highly contributed to the discrimination of A and B clusters. CONCLUSION:Classification of breast tumors into rapidly progressive cluster A and the other (cluster B) may contributeto select the treatment appropriate for their progression risk. |
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| 言語 | en | |||||
| 書誌情報 |
en : Pathobiology 巻 86, 号 2-3, p. 92-101, 発行日 2018-10-17 |
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| 出版者 | ||||||
| 出版者 | Karger | |||||
| 言語 | en | |||||
| ISSN | ||||||
| 収録物識別子タイプ | EISSN | |||||
| 収録物識別子 | 1423-0291 | |||||
| PMID | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 30332671 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1159/000492833 | |||||
| 権利 | ||||||
| 言語 | en | |||||
| 権利情報 | © 2018 S. Karger AG, Basel. | |||||
| 権利 | ||||||
| 言語 | en | |||||
| 権利情報 | All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. | |||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
