{"created":"2023-06-19T10:43:11.014221+00:00","id":3349,"links":{},"metadata":{"_buckets":{"deposit":"a353257f-bc3b-4d66-9b72-f2b380eb7de9"},"_deposit":{"created_by":11,"id":"3349","owners":[11],"pid":{"revision_id":0,"type":"depid","value":"3349"},"status":"published"},"_oai":{"id":"oai:shiga-med.repo.nii.ac.jp:00003349","sets":["30:217:218"]},"author_link":["404","2852","1985","408","218","7460","12","696","7601","404","2852","1985","408","218","7460","12","696","7601"],"control_number":"3349","item_4_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-10-17","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2-3","bibliographicPageEnd":"101","bibliographicPageStart":"92","bibliographicVolumeNumber":"86","bibliographic_titles":[{"bibliographic_title":"Pathobiology","bibliographic_titleLang":"en"}]}]},"item_4_creator_3":{"attribute_name":"著者別名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"北村, 美奈","creatorNameLang":"ja"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"仲山, 貴永","creatorNameLang":"ja"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"向所, 賢一","creatorNameLang":"ja"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"森, 毅","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"梅田, 朋子","creatorNameLang":"ja"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"森谷, 鈴子","creatorNameLang":"ja"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"九嶋, 亮治","creatorNameLang":"ja"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"谷, 眞至","creatorNameLang":"ja"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"杉原, 洋行","creatorNameLang":"ja"}],"nameIdentifiers":[{},{}]}]},"item_4_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"BACKGROUND:Ductal carcinoma in situ (DCIS) of the breast is heterogeneous in terms of the risk of progression to invasive ductal carcinoma (IDC). To treat DCIS appropriately for its progression risk, we classified individual DCIS by its profile of genomic changes into 2 groups and correlated them with clinicopathological progression factors.\n\nMETHODS:We used surgically resected, formalin-fixed, paraffin-embedded tissues of 22 DCIS and 30 IDC lesions. We performed immunohistochemical intrinsic subtyping, array-based comparative genomic hybridization, and unsupervised clustering.\n\nRESULTS:The samples were divided into 2 major clusters, A and B. Cluster A showed a greater number of gene and chromosome copy number alterations, a larger IDC/DCIS ratio, a higher frequency of nonluminal subtype, a lower frequency of luminal subtype, and a higher nuclear grade, when compared with cluster B. However, there was no difference in the frequencies of lymph node metastasis between clusters A and B. We identified 9 breast-cancer-related genes, including TP53 and GATA3, that highly contributed to the discrimination of A and B clusters.\n\nCONCLUSION:Classification of breast tumors into rapidly progressive cluster A and the other (cluster B) may contributeto select the treatment appropriate for their progression risk.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_4_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Karger","subitem_publisher_language":"en"}]},"item_4_relation_10":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"30332671","subitem_relation_type_select":"PMID"}}]},"item_4_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1159/000492833","subitem_relation_type_select":"DOI"}}]},"item_4_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2018 S. Karger AG, Basel.","subitem_rights_language":"en"},{"subitem_rights":"All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.","subitem_rights_language":"en"}]},"item_4_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1423-0291","subitem_source_identifier_type":"EISSN"}]},"item_4_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"KITAMURA, Mina","creatorNameLang":"en"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"NAKAYAMA, Takahisa","creatorNameLang":"en"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"MUKAISHO, Ken-ichi","creatorNameLang":"en"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"MORI, Tsuyoshi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"UMEDA, Tomoko","creatorNameLang":"en"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Moritani, Suzuko","creatorNameLang":"en"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"KUSHIMA, Ryoji","creatorNameLang":"en"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"TANI, Masaji","creatorNameLang":"en"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"SUGIHARA, Hiroyuki","creatorNameLang":"en"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-02-22"}],"displaytype":"detail","filename":"10.1159000492833.pdf","filesize":[{"value":"1.3 MB"}],"format":"application/pdf","license_note":"All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"10.1159000492833","url":"https://shiga-med.repo.nii.ac.jp/record/3349/files/10.1159000492833.pdf"},"version_id":"6261c01c-ae98-4a00-b180-a68578f67b52"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Copy number alterations","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Array-based comparative genomic hybridization","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Breast cancer","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Ductal carcinoma in situ","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Unsupervised hierarchical clustering","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Progression Potential of Ductal Carcinoma in situ Assessed by Genomic Copy Number Profiling.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Progression Potential of Ductal Carcinoma in situ Assessed by Genomic Copy Number Profiling.","subitem_title_language":"en"}]},"item_type_id":"4","owner":"11","path":["218"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2019-02-22"},"publish_date":"2019-02-22","publish_status":"0","recid":"3349","relation_version_is_last":true,"title":["Progression Potential of Ductal Carcinoma in situ Assessed by Genomic Copy Number Profiling."],"weko_creator_id":"11","weko_shared_id":-1},"updated":"2023-10-19T09:22:33.544188+00:00"}