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Prominent role of RAB39A-RXRB axis in cancer development and stemness
http://hdl.handle.net/10422/00012363
http://hdl.handle.net/10422/00012363f93c11e3-15a9-4051-9192-c128a667af6b
名前 / ファイル | ライセンス | アクション |
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oncotarget.23955 (7.4 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2018-01-15 | |||||
タイトル | ||||||
タイトル | Prominent role of RAB39A-RXRB axis in cancer development and stemness | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | RAB39A | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | RXRB | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | cancer stem cell | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | spherogenicity | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | tumorigenesis | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
茶野, 徳宏
× 茶野, 徳宏× Kita, Hiroko× Avnet, Sofia× Lemma, Silvia× Baldini, Nicola |
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著者別名 |
茶野, 徳宏
× 茶野, 徳宏× 喜多, 寛子 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | In this study, we found that RAB39A, a member of the RAS oncogene family, was selectively expressed in cancer cells of different histotypes, by analyzing gene expression in human osteosarcoma cells and the cancer stem cells (CSCs) and by comparing them with normal cells through global transcriptomics and principal component analyses. We further validated RAB39A as a therapeutic target, by silencing its expression. The silencing impaired cancer stemness and spherogenic ability in vitro, as well as tumorigenesis in vivo. RNA-seq analyses in the silenced spheres suggested that RAB39A is associated downstream with RXRB and KLF4. Notably, RXRB expression was inhibited in RAB39A-silenced CSCs. Induced overexpression of RXRB in RAB39A-silenced cells restored spherogenic ability and tumorigenesis, confirming RXRB as a major effector of RAB39A. Quantitative RT-PCR analysis of ~400 human cancer tissues showed that RAB39A was highly expressed in sarcomas and in malignancies of lymphoid, adrenal and testicular tissues. Our data provide the rationale for targeting of the RAB39A-RXRB axis as a therapy for aggressive cancers. |
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書誌情報 |
en : Oncotarget 発行日 2018-01-04 |
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出版者 | ||||||
出版者 | Impact Journals LLC | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1949-2553 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.18632/oncotarget.23955 | |||||
権利 | ||||||
権利情報 | All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 3.0 License. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
資源タイプ | ||||||
内容記述タイプ | Other | |||||
内容記述 | Journal Article |