{"created":"2023-06-19T10:43:05.242409+00:00","id":3224,"links":{},"metadata":{"_buckets":{"deposit":"360061eb-2f97-4e6c-a919-e0b6842da37b"},"_deposit":{"created_by":11,"id":"3224","owners":[11],"pid":{"revision_id":0,"type":"depid","value":"3224"},"status":"published"},"_oai":{"id":"oai:shiga-med.repo.nii.ac.jp:00003224","sets":["30:196:197"]},"author_link":["7216","7219","7217","7218","561"],"item_4_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-01-04","bibliographicIssueDateType":"Issued"},"bibliographic_titles":[{},{"bibliographic_title":"Oncotarget","bibliographic_titleLang":"en"}]}]},"item_4_creator_3":{"attribute_name":"著者別名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"茶野, 徳宏"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"喜多, 寛子"}],"nameIdentifiers":[{}]}]},"item_4_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"In this study, we found that RAB39A, a member of the RAS oncogene family, was \nselectively expressed in cancer cells of different histotypes, by analyzing gene expression \nin human osteosarcoma cells and the cancer stem cells (CSCs) and by comparing them \nwith normal cells through global transcriptomics and principal component analyses. We\nfurther validated RAB39A as a therapeutic target, by silencing its expression. The \nsilencing impaired cancer stemness and spherogenic ability in vitro, as well as \ntumorigenesis in vivo. RNA-seq analyses in the silenced spheres suggested that RAB39A\nis associated downstream with RXRB and KLF4. Notably, RXRB expression was inhibited\nin RAB39A-silenced CSCs. Induced overexpression of RXRB in RAB39A-silenced cells \nrestored spherogenic ability and tumorigenesis, confirming RXRB as a major effector of \nRAB39A. Quantitative RT-PCR analysis of ~400 human cancer tissues showed that \nRAB39A was highly expressed in sarcomas and in malignancies of lymphoid, adrenal and\ntesticular tissues. Our data provide the rationale for targeting of the RAB39A-RXRB axis \nas a therapy for aggressive cancers.","subitem_description_type":"Abstract"}]},"item_4_description_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Journal Article ","subitem_description_type":"Other"}]},"item_4_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Impact Journals LLC"}]},"item_4_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.18632/oncotarget.23955","subitem_relation_type_select":"DOI"}}]},"item_4_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 3.0 License. "}]},"item_4_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1949-2553","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"茶野, 徳宏"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Kita, Hiroko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Avnet, Sofia"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Lemma, Silvia"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Baldini, Nicola"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-01-15"}],"displaytype":"detail","filename":"oncotarget.23955.pdf","filesize":[{"value":"7.4 MB"}],"format":"application/pdf","licensetype":"license_6","mimetype":"application/pdf","url":{"label":"oncotarget.23955","url":"https://shiga-med.repo.nii.ac.jp/record/3224/files/oncotarget.23955.pdf"},"version_id":"f09eeb4e-3994-4f05-9d84-7bc11b6f06dc"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"RAB39A","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"RXRB","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"cancer stem cell","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"spherogenicity","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"tumorigenesis","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Prominent role of RAB39A-RXRB axis in cancer development and stemness","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Prominent role of RAB39A-RXRB axis in cancer development and stemness"}]},"item_type_id":"4","owner":"11","path":["197"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-01-15"},"publish_date":"2018-01-15","publish_status":"0","recid":"3224","relation_version_is_last":true,"title":["Prominent role of RAB39A-RXRB axis in cancer development and stemness"],"weko_creator_id":"11","weko_shared_id":-1},"updated":"2023-06-19T12:28:00.076431+00:00"}