WEKO3
-
RootNode
アイテム
Association of variations in HLA class II and other loci with susceptibility to EGFR-mutated lung adenocarcinoma.
http://hdl.handle.net/10422/00012326
http://hdl.handle.net/10422/000123262bb15215-aab5-4fdf-8903-ee2a11fd030c
名前 / ファイル | ライセンス | アクション |
---|---|---|
![]() |
© The Author(s) 2016. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
|
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2017-09-06 | |||||
タイトル | ||||||
タイトル | Association of variations in HLA class II and other loci with susceptibility to EGFR-mutated lung adenocarcinoma. | |||||
言語 | en | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
著者 |
SHIRAISHI, Kouya
× SHIRAISHI, Kouya× OKADA, Yukinori× TAKAHASHI, Atsushi× KAMATANI, Yoichiro× MOMOZAWA, Yukihide× ASHIKAWA, Kyota× KUNITOH, Hideo× MATSUMOTO, Shingo× TAKANO, Atsushi× SHIMIZU, Kimihiro× GOTO, Akiteru× TSUTA, Koji× WATANABE, Shun-Ichi× OHE, Yuichiro× WATANABE, Yukio× GOTO, Yasushi× NOKIHARA, Hiroshi× FURUTA, Koh× YOSHIDA, Akihiko× GOTO, Koichi× HISHIDA, Tomoyuki× TSUBOI, Masahiro× TSUCHIHARA, Katsuya× MIYAGI, Yohei× NAKAYAMA, Haruhiko× YOKOSE, Tomoyuki× TANAKA, Kazumi× NAGASHIMA, Toshitetsu× OHTAKI, Yoichi× MAEDA, Daichi× IMAI, Kazuhiro× MINAMIYA, Yoshihiro× SAKAMOTO, Hiromi× SAITO, Akira× SHIMADA, Yoko× SUNAMI, Kuniko× SAITO, Motonobu× INAZAWA, Johji× NAKAMURA, Yusuke× YOSHIDA, Teruhiko× YOKOTA, Jun× MATSUDA, Fumihiko× MATSUO, Keitaro× DAIGO, Yataro× KUBO, Michiaki× KOHNO, Takashi |
|||||
著者別名 |
醍醐, 弥太郎
× 醍醐, 弥太郎 |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Lung adenocarcinoma driven by somatic EGFR mutations is more prevalent in East Asians (30-50%) than in European/Americans (10-20%). Here we investigate genetic factors underlying the risk of this disease by conducting a genome-wide association study, followed by two validation studies, in 3,173 Japanese patients with EGFR mutation-positive lung adenocarcinoma and 15,158 controls. Four loci, 5p15.33 (TERT), 6p21.3 (BTNL2), 3q28 (TP63) and 17q24.2 (BPTF), previously shown to be strongly associated with overall lung adenocarcinoma risk in East Asians, were re-discovered as loci associated with a higher susceptibility to EGFR mutation-positive lung adenocarcinoma. In addition, two additional loci, HLA class II at 6p21.32 (rs2179920; P =5.1 × 10(-17), per-allele OR=1.36) and 6p21.1 (FOXP4) (rs2495239; P=3.9 × 10(-9), per-allele OR=1.19) were newly identified as loci associated with EGFR mutation-positive lung adenocarcinoma. This study indicates that multiple genetic factors underlie the risk of lung adenocarcinomas with EGFR mutations. | |||||
言語 | en | |||||
書誌情報 |
en : Nature communications 巻 7, 発行日 2016-08-09 |
|||||
出版者 | ||||||
出版者 | Springer Nature | |||||
言語 | en | |||||
ISSN | ||||||
収録物識別子タイプ | EISSN | |||||
収録物識別子 | 2041-1723 | |||||
PMID | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 27501781 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1038/ncomms12451 | |||||
権利 | ||||||
言語 | en | |||||
権利情報 | This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |