{"created":"2023-06-19T10:43:03.461371+00:00","id":3174,"links":{},"metadata":{"_buckets":{"deposit":"64136f44-6a65-4ddf-ae93-61b9e500d579"},"_deposit":{"created_by":11,"id":"3174","owners":[11],"pid":{"revision_id":0,"type":"depid","value":"3174"},"status":"published"},"_oai":{"id":"oai:shiga-med.repo.nii.ac.jp:00003174","sets":["30:85"]},"author_link":["7111","7112","566","7108","7121","7123","7100","7130","7135","7140","7132","7101","7139","7116","7099","7106","7128","7124","7104","7113","7118","7122","7136","7117","7137","562","7133","7114","7129","7120","7141","7119","7105","7126","7109","7102","7103","7127","7144","7134","7110","7125","7131","7115","7138","7143"],"item_4_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-08-09","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"12451","bibliographicVolumeNumber":"7","bibliographic_titles":[{"bibliographic_title":"Nature communications"}]}]},"item_4_creator_3":{"attribute_name":"著者別名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"醍醐, 弥太郎"}],"nameIdentifiers":[{},{}]}]},"item_4_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Lung adenocarcinoma driven by somatic EGFR mutations is more prevalent in East Asians (30-50%) than in European/Americans (10-20%). Here we investigate genetic factors underlying the risk of this disease by conducting a genome-wide association study, followed by two validation studies, in 3,173 Japanese patients with EGFR mutation-positive lung adenocarcinoma and 15,158 controls. Four loci, 5p15.33 (TERT), 6p21.3 (BTNL2), 3q28 (TP63) and 17q24.2 (BPTF), previously shown to be strongly associated with overall lung adenocarcinoma risk in East Asians, were re-discovered as loci associated with a higher susceptibility to EGFR mutation-positive lung adenocarcinoma. In addition, two additional loci, HLA class II at 6p21.32 (rs2179920; P =5.1 × 10(-17), per-allele OR=1.36) and 6p21.1 (FOXP4) (rs2495239; P=3.9 × 10(-9), per-allele OR=1.19) were newly identified as loci associated with EGFR mutation-positive lung adenocarcinoma. This study indicates that multiple genetic factors underlie the risk of lung adenocarcinomas with EGFR mutations.","subitem_description_type":"Abstract"}]},"item_4_description_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Journal Article","subitem_description_type":"Other"}]},"item_4_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer Nature"}]},"item_4_relation_10":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"27501781","subitem_relation_type_select":"PMID"}}]},"item_4_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1038/ncomms12451","subitem_relation_type_select":"DOI"}}]},"item_4_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/"}]},"item_4_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2041-1723","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Shiraishi, Kouya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Okada, Yukinori"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takahashi, Atsushi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kamatani, Yoichiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Momozawa, Yukihide"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Ashikawa, Kyota"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kunitoh, Hideo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Matsumoto, Shingo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"TAKANO, Atsushi"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Shimizu, Kimihiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Goto, Akiteru"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tsuta, Koji"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Watanabe, Shun-Ichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ohe, Yuichiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Watanabe, Yukio"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Goto, Yasushi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nokihara, Hiroshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Furuta, Koh"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yoshida, Akihiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Goto, Koichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hishida, Tomoyuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tsuboi, Masahiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tsuchihara, Katsuya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Miyagi, Yohei"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakayama, Haruhiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yokose, Tomoyuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tanaka, Kazumi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nagashima, Toshiteru"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ohtaki, Yoichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Maeda, Daichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Imai, Kazuhiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Minamiya, Yoshihiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sakamoto, Hiromi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Saito, Akira"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shimada, Yoko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sunami, Kuniko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Saito, Motonobu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Inazawa, Johji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakamura, Yusuke"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yoshida, Teruhiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yokota, Jun"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Matsuda, Fumihiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Matsuo, Keitaro"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"DAIGO, Yataro"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Kubo, Michiaki"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Kohno, Takashi"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-09-06"}],"displaytype":"detail","filename":"ncomms12451.pdf","filesize":[{"value":"507.9 kB"}],"format":"application/pdf","license_note":"© The Author(s) 2016. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material\nin this article are included in the article's Creative Commons license, unless\nindicated otherwise in the credit line; if the material is not included under the\nCreative Commons license, users will need to obtain permission from the \nlicense holder to reproduce the material. To view a copy of this license, \nvisit http://creativecommons.org/licenses/by/4.0/","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"ncomms12451","url":"https://shiga-med.repo.nii.ac.jp/record/3174/files/ncomms12451.pdf"},"version_id":"64bd5aea-6e63-4dec-af63-15762b5681bd"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Association of variations in HLA class II and other loci with susceptibility to EGFR-mutated lung adenocarcinoma.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Association of variations in HLA class II and other loci with susceptibility to EGFR-mutated lung adenocarcinoma."}]},"item_type_id":"4","owner":"11","path":["85"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-09-06"},"publish_date":"2017-09-06","publish_status":"0","recid":"3174","relation_version_is_last":true,"title":["Association of variations in HLA class II and other loci with susceptibility to EGFR-mutated lung adenocarcinoma."],"weko_creator_id":"11","weko_shared_id":-1},"updated":"2023-06-19T11:44:45.378590+00:00"}