WEKO3
アイテム
{"_buckets": {"deposit": "b3de5509-fa59-435d-87f6-ad2118258016"}, "_deposit": {"created_by": 11, "id": "4107", "owners": [11], "pid": {"revision_id": 0, "type": "depid", "value": "4107"}, "status": "published"}, "_oai": {"id": "oai:shiga-med.repo.nii.ac.jp:00004107", "sets": ["228"]}, "author_link": ["706", "8835", "7253", "7638", "644", "8836", "7639", "7509"], "item_4_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2022-01", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "1", "bibliographicPageEnd": "71", "bibliographicPageStart": "64", "bibliographicVolumeNumber": "70", "bibliographic_titles": [{}, {"bibliographic_title": "Journal of Clinical Biochemistry and Nutrition", "bibliographic_titleLang": "en"}]}]}, "item_4_creator_3": {"attribute_name": "著者別名", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "大野, 将司"}], "nameIdentifiers": [{"nameIdentifier": "7253", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "80845488", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=80845488"}, {"nameIdentifier": "0000-0003-3505-7835", "nameIdentifierScheme": "ORCID", "nameIdentifierURI": "https://orcid.org/0000-0003-3505-7835"}]}, {"creatorNames": [{"creatorName": "今井, 隆行"}], "nameIdentifiers": [{"nameIdentifier": "7638", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "0000-0002-9170-4075", "nameIdentifierScheme": "ORCID", "nameIdentifierURI": "https://orcid.org/0000-0002-9170-4075"}]}, {"creatorNames": [{"creatorName": "茶谷, 元晴"}], "nameIdentifiers": [{"nameIdentifier": "8835", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "西田, 淳史"}], "nameIdentifiers": [{"nameIdentifier": "7639", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "90719915", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=90719915"}, {"nameIdentifier": "0000-0002-1288-3272", "nameIdentifierScheme": "ORCID", "nameIdentifierURI": "https://orcid.org/0000-0002-1288-3272"}]}, {"creatorNames": [{"creatorName": "稲富, 理"}], "nameIdentifiers": [{"nameIdentifier": "706", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "70530351", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=70530351"}, {"nameIdentifier": "0000-0002-5837-6575", "nameIdentifierScheme": "ORCID", "nameIdentifierURI": "https://orcid.org/0000-0002-5837-6575"}]}, {"creatorNames": [{"creatorName": "河原, 真大"}], "nameIdentifiers": [{"nameIdentifier": "7509", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "80617449", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=80617449"}, {"nameIdentifier": "0000-0002-2721-7571", "nameIdentifierScheme": "ORCID", "nameIdentifierURI": "https://orcid.org/0000-0002-2721-7571"}]}, {"creatorNames": [{"creatorName": "安藤, 朗"}], "nameIdentifiers": [{"nameIdentifier": "644", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "90252395", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=90252395"}, {"nameIdentifier": "0000-0001-8533-2669", "nameIdentifierScheme": "ORCID", "nameIdentifierURI": "https://orcid.org/0000-0001-8533-2669"}]}]}, "item_4_description_14": {"attribute_name": "フォーマット", "attribute_value_mlt": [{"subitem_description": "pdf", "subitem_description_type": "Other"}]}, "item_4_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Interleukin (IL)-38 exerts an anti-inflammatory function by binding to several cytokine receptors, including the IL-36 receptor. In this study, we evaluated IL-38 expression in the inflamed mucosa of patients with inflammatory bowel disease (IBD) and investigated its functions. IL-38 mRNA expression in endoscopic biopsy samples was evaluated using quantitative PCR. IL-38 protein expression was analyzed using immunohistochemical technique. Dextran sulfate sodium-induced colitis was induced in C57BL/6 background IL-38KO mice. The IL-38 mRNA and protein expression were enhanced in the active mucosa of ulcerative colitis, but not in Crohn\u0027s disease. The ratio of IL-36γ to IL-38 mRNA expression was significantly elevated in the active mucosa of UC patients. Immunofluorescence staining revealed that B cells are the major cellular source of IL-38 in the colonic mucosa. IL-38 dose-dependently suppressed the IL-36γ-induced mRNA expression of CXC chemokines (CXCL1, CXCL2, and CXCL8) in HT-29 and T84 cells. IL-38 inhibited the IL-36γ-induced activation of nuclear-factor kappa B (NF-κB) and mitogen-activated protein kinases in HT-29 cells. DSS-colitis was significantly exacerbated in IL-38KO mice compared to wild type mice. In conclusion, IL-38 may play an anti-inflammatory and protective role in the pathophysiology of IBD, in particular ulcerative colitis, through the suppression of IL-36-induced inflammatory responses. ", "subitem_description_type": "Abstract"}]}, "item_4_description_42": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"subitem_description": "Journal Article", "subitem_description_type": "Other"}]}, "item_4_publisher_32": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "The Society for Free Radical Research Japan"}]}, "item_4_relation_10": {"attribute_name": "PubMed番号", "attribute_value_mlt": [{"subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "35068683", "subitem_relation_type_select": "PMID"}}]}, "item_4_relation_11": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "10.3164/jcbn.21-104"}], "subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.3164/jcbn.21-104", "subitem_relation_type_select": "DOI"}}]}, "item_4_relation_13": {"attribute_name": "PMCID", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "PMC8764106"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "http://www.ncbi.nlm.nih.gov/pmc/articles/pmc8764106/", "subitem_relation_type_select": "URI"}}]}, "item_4_rights_12": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "© 2022 JCBN"}]}, "item_4_source_id_7": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0912-0009", "subitem_source_identifier_type": "ISSN"}]}, "item_4_version_type_15": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "OHNO, Masashi"}], "nameIdentifiers": [{"nameIdentifier": "7253", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "80845488", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=80845488"}, {"nameIdentifier": "0000-0003-3505-7835", "nameIdentifierScheme": "ORCID", "nameIdentifierURI": "https://orcid.org/0000-0003-3505-7835"}]}, {"creatorNames": [{"creatorName": "IMAI, Takayuki"}], "nameIdentifiers": [{"nameIdentifier": "7638", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "0000-0002-9170-4075", "nameIdentifierScheme": "ORCID", "nameIdentifierURI": "https://orcid.org/0000-0002-9170-4075"}]}, {"creatorNames": [{"creatorName": "CHATANI, Motoharu"}], "nameIdentifiers": [{"nameIdentifier": "8835", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "NISHIDA, Atsushi"}], "nameIdentifiers": [{"nameIdentifier": "7639", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "90719915", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=90719915"}, {"nameIdentifier": "0000-0002-1288-3272", "nameIdentifierScheme": "ORCID", "nameIdentifierURI": "https://orcid.org/0000-0002-1288-3272"}]}, {"creatorNames": [{"creatorName": "INATOMI, Osamu"}], "nameIdentifiers": [{"nameIdentifier": "706", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "70530351", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=70530351"}, {"nameIdentifier": "0000-0002-5837-6575", "nameIdentifierScheme": "ORCID", "nameIdentifierURI": "https://orcid.org/0000-0002-5837-6575"}]}, {"creatorNames": [{"creatorName": "KAWAHARA, Masahiro"}], "nameIdentifiers": [{"nameIdentifier": "7509", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "80617449", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=80617449"}, {"nameIdentifier": "0000-0002-2721-7571", "nameIdentifierScheme": "ORCID", "nameIdentifierURI": "https://orcid.org/0000-0002-2721-7571"}]}, {"creatorNames": [{"creatorName": "HOSHINO, Tomoaki"}], "nameIdentifiers": [{"nameIdentifier": "8836", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "ANDOH, Akira"}], "nameIdentifiers": [{"nameIdentifier": "644", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "90252395", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=90252395"}, {"nameIdentifier": "0000-0001-8533-2669", "nameIdentifierScheme": "ORCID", "nameIdentifierURI": "https://orcid.org/0000-0001-8533-2669"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2022-02-02"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "jcbn.21-104.pdf", "filesize": [{"value": "3.4 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensefree": "This is an open access article distributed under the terms of the Creative \nCommons Attribution-NonCommercial-NoDerivatives License.\nhttps://creativecommons.org/licenses/by-nc-nd/4.0/", "licensetype": "license_free", "mimetype": "application/pdf", "size": 3400000.0, "url": {"label": "jcbn.21-104", "url": "https://shiga-med.repo.nii.ac.jp/record/4107/files/jcbn.21-104.pdf"}, "version_id": "d3559da5-9cf0-4f2b-be12-02468b8147a4"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2022-02-02"}], "displaytype": "detail", "download_preview_message": "", "file_order": 1, "filename": "jcbn.21-104_Supplemental Table1.pdf", "filesize": [{"value": "50.1 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensefree": "This is an open access article distributed under the terms of the Creative \nCommons Attribution-NonCommercial-NoDerivatives License.\nhttps://creativecommons.org/licenses/by-nc-nd/4.0/", "licensetype": "license_free", "mimetype": "application/pdf", "size": 50100.0, "url": {"label": "jcbn.21-104_Supplemental Table1", "url": "https://shiga-med.repo.nii.ac.jp/record/4107/files/jcbn.21-104_Supplemental Table1.pdf"}, "version_id": "77f947e4-48f1-47f4-a760-d4e778e6fcc2"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2022-02-02"}], "displaytype": "detail", "download_preview_message": "", "file_order": 2, "filename": "jcbn.21-104_Supplemental Table2.pdf", "filesize": [{"value": "27.6 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensefree": "This is an open access article distributed under the terms of the Creative \nCommons Attribution-NonCommercial-NoDerivatives License.\nhttps://creativecommons.org/licenses/by-nc-nd/4.0/", "licensetype": "license_free", "mimetype": "application/pdf", "size": 27600.0, "url": {"label": "jcbn.21-104_Supplemental Table2", "url": "https://shiga-med.repo.nii.ac.jp/record/4107/files/jcbn.21-104_Supplemental Table2.pdf"}, "version_id": "44016122-887f-4576-89fd-118232d4294a"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "inflammatory bowel disease", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "ulcerative colitis", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "interleukin-38", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "interleukin-36", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "The anti-inflammatory and protective role of interleukin-38 in inflammatory bowel disease.", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "The anti-inflammatory and protective role of interleukin-38 in inflammatory bowel disease."}]}, "item_type_id": "4", "owner": "11", "path": ["228"], "permalink_uri": "http://hdl.handle.net/10422/00013201", "pubdate": {"attribute_name": "公開日", "attribute_value": "2022-02-02"}, "publish_date": "2022-02-02", "publish_status": "0", "recid": "4107", "relation": {}, "relation_version_is_last": true, "title": ["The anti-inflammatory and protective role of interleukin-38 in inflammatory bowel disease."], "weko_shared_id": -1}
The anti-inflammatory and protective role of interleukin-38 in inflammatory bowel disease.
http://hdl.handle.net/10422/00013201
http://hdl.handle.net/10422/0001320159c540f9-5d40-4676-82f6-f56c6ee76197
名前 / ファイル | ライセンス | アクション |
---|---|---|
jcbn.21-104 (3.4 MB)
|
This is an open access article distributed under the terms of the Creative
Commons Attribution-NonCommercial-NoDerivatives License. https://creativecommons.org/licenses/by-nc-nd/4.0/ |
|
jcbn.21-104_Supplemental Table1 (50.1 kB)
|
This is an open access article distributed under the terms of the Creative
Commons Attribution-NonCommercial-NoDerivatives License. https://creativecommons.org/licenses/by-nc-nd/4.0/ |
|
jcbn.21-104_Supplemental Table2 (27.6 kB)
|
This is an open access article distributed under the terms of the Creative
Commons Attribution-NonCommercial-NoDerivatives License. https://creativecommons.org/licenses/by-nc-nd/4.0/ |
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2022-02-02 | |||||
タイトル | ||||||
タイトル | The anti-inflammatory and protective role of interleukin-38 in inflammatory bowel disease. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | inflammatory bowel disease | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | ulcerative colitis | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | interleukin-38 | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | interleukin-36 | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
OHNO, Masashi
× OHNO, Masashi× IMAI, Takayuki× CHATANI, Motoharu× NISHIDA, Atsushi× INATOMI, Osamu× KAWAHARA, Masahiro× HOSHINO, Tomoaki× ANDOH, Akira |
|||||
著者別名 |
大野, 将司
× 大野, 将司× 今井, 隆行× 茶谷, 元晴× 西田, 淳史× 稲富, 理× 河原, 真大× 安藤, 朗 |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Interleukin (IL)-38 exerts an anti-inflammatory function by binding to several cytokine receptors, including the IL-36 receptor. In this study, we evaluated IL-38 expression in the inflamed mucosa of patients with inflammatory bowel disease (IBD) and investigated its functions. IL-38 mRNA expression in endoscopic biopsy samples was evaluated using quantitative PCR. IL-38 protein expression was analyzed using immunohistochemical technique. Dextran sulfate sodium-induced colitis was induced in C57BL/6 background IL-38KO mice. The IL-38 mRNA and protein expression were enhanced in the active mucosa of ulcerative colitis, but not in Crohn's disease. The ratio of IL-36γ to IL-38 mRNA expression was significantly elevated in the active mucosa of UC patients. Immunofluorescence staining revealed that B cells are the major cellular source of IL-38 in the colonic mucosa. IL-38 dose-dependently suppressed the IL-36γ-induced mRNA expression of CXC chemokines (CXCL1, CXCL2, and CXCL8) in HT-29 and T84 cells. IL-38 inhibited the IL-36γ-induced activation of nuclear-factor kappa B (NF-κB) and mitogen-activated protein kinases in HT-29 cells. DSS-colitis was significantly exacerbated in IL-38KO mice compared to wild type mice. In conclusion, IL-38 may play an anti-inflammatory and protective role in the pathophysiology of IBD, in particular ulcerative colitis, through the suppression of IL-36-induced inflammatory responses. | |||||
書誌情報 |
en : Journal of Clinical Biochemistry and Nutrition 巻 70, 号 1, p. 64-71, 発行日 2022-01 |
|||||
出版者 | ||||||
出版者 | The Society for Free Radical Research Japan | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0912-0009 | |||||
PMID | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | 35068683 | |||||
PMCID | ||||||
識別子タイプ | URI | |||||
関連識別子 | http://www.ncbi.nlm.nih.gov/pmc/articles/pmc8764106/ | |||||
関連名称 | PMC8764106 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.3164/jcbn.21-104 | |||||
関連名称 | 10.3164/jcbn.21-104 | |||||
権利 | ||||||
権利情報 | © 2022 JCBN | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | ||||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
資源タイプ | ||||||
内容記述タイプ | Other | |||||
内容記述 | Journal Article |