@article{oai:shiga-med.repo.nii.ac.jp:00000057, author = {張, 陽 and 藤宮, 峯子 and FUJIMIYA, Mineko and 寺田, 信國 and TERADA, Nobukuni and 前田, 敏博 and MAEDA, Toshihiro and 小玉, 正智 and KODAMA, Masashi}, journal = {滋賀医科大学雑誌}, month = {Feb}, note = {The origin of serotonin nerve fibers distributed around submucosal blood vessels in the rat small intestine was studied by immunohistochemistry. In colchicine- and pargyline-treated animals, serotonin-immunoreactive nerve cell bodies were located in the myentenc plexus, andpositive nerve fibers were widely distributed in the myenteric plexus, submucosal plexus, muscle layer and lamina propria of mucosa. Most remarkably, positive nerve fibers were densely distributed around submucosal blood vessels. Mechanical sympathectomy caused a complete disappearance of perivascular positive fibers, however positive fibers in the lamina propria, submucosa and muscle layers were not affected, Positive cell bodies were not found in the celiac sympathetic ganglia but were found in dorsal root ganglia. In a dorsal root ganglion, serotonin was colocalized with substance P, but not colocalized with calcitonin gene-related peptide m nerve cell bodies. Capsaicin treatment on the celiac sympathetic ganglion induced a simultaneous disappearance of serotonin-, calcitonin gene-related peptide- and substance P-immunoreactive nerve fibers around submucosal blood vessels. These results indicate that serotonin-containingnerve fibers around submucosal blood vessels are of extrinsic origin, and they are primaryafferent derived from dorsal root ganglia.}, pages = {41--48}, title = {ラット腸管粘膜下血管周囲のセロトニン含有神経の起源に関する免疫組織化学的研究}, volume = {13}, year = {1998}, yomi = {フジミヤ, ミネコ and テラダ, ノブクニ and マエダ, トシヒロ and コダマ, マサシ} }