{"created":"2023-06-19T10:44:06.334450+00:00","id":4486,"links":{},"metadata":{"_buckets":{"deposit":"ab8394a2-ded4-402d-ae19-7067ed91cfae"},"_deposit":{"created_by":11,"id":"4486","owners":[11],"pid":{"revision_id":0,"type":"depid","value":"4486"},"status":"published"},"_oai":{"id":"oai:shiga-med.repo.nii.ac.jp:00004486","sets":["30:227:228"]},"author_link":["644","7639"],"item_4_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-12-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3-4","bibliographicPageEnd":"127","bibliographicPageStart":"119","bibliographicVolumeNumber":"7","bibliographic_titles":[{},{"bibliographic_title":"Surgical Neurology International","bibliographic_titleLang":"en"}]}]},"item_4_creator_3":{"attribute_name":"著者別名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"安藤, 朗"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"西田, 淳史"}],"nameIdentifiers":[{},{},{}]}]},"item_4_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_4_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background:\nIntestinal fibrosis in Crohn's disease (CD) is considered to be irreversible and induces persistent luminal narrowing and strictures. In the past decades, substantial advances have been made in the understanding of the cellular and molecular mechanisms underlying intestinal fibrosis in inflammatory bowel disease (IBD). ","subitem_description_type":"Abstract"},{"subitem_description":"Summary:\nIntestinal fibrosis is typically associated with mesenchymal cell hyperplasia, tissue disorganization, and deposition of extracellular matrix (ECM). The transient appearance of mesenchymal cells is a feature of normal wound healing, but the persistence of these cells is associated with ECM deposition and fibrosis, leading to loss of normal architecture and function. When homeostatic control of the repair process becomes dysregulated, perpetual activation of profibrotic responses and sustained accumulation of ECM are induced. In the process of intestinal fibrosis, myofibroblasts are considered to be the key effector cells, being responsible for the synthesis of ECM proteins. Activation and accumulation of myofibroblasts in the stricturing lesions of CD patients are mediated by various factors such as growth factors, cytokines, epithelial-to-mesenchymal or endothelial-to-mesenchymal transitions. Despite the identification of many putative targets and target pathways applicable to antifibrotic therapies, no such treatment has yet been successful. Predictive biomarkers and non-invasive diagnostic tools for intestinal fibrosis are still insufficient in IBD. ","subitem_description_type":"Abstract"},{"subitem_description":"Key message:\nWe summarize recent advances in the understanding of the cellular and molecular mechanisms underlying intestinal fibrosis in IBD. ","subitem_description_type":"Abstract"}]},"item_4_description_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Journal Article","subitem_description_type":"Other"}]},"item_4_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"S. Karger AG"}]},"item_4_relation_10":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"37064539","subitem_relation_type_select":"PMID"}}]},"item_4_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"10.1159/000528312"}],"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1159/000528312","subitem_relation_type_select":"DOI"}}]},"item_4_relation_13":{"attribute_name":"PMCID","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"PMC10091027"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.ncbi.nlm.nih.gov/pmc/articles/pmc10091027/","subitem_relation_type_select":"URI"}}]},"item_4_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2022 by The Author(s)."}]},"item_4_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2296-9403","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"ANDOH, Akira"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"NISHIDA, Atsushi"}],"nameIdentifiers":[{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-05-16"}],"displaytype":"detail","filename":"000528312.pdf","filesize":[{"value":"517.5 kB"}],"format":"application/pdf","license_note":"This is an Open Access article licensed under the Creative Commons Attribution-Non Commercial-4.0 International License (CC BY-NC)\n(http://www.karger.com/Services/OpenAccessLicense), applicable to the online version of the article only. Usage and distribution for commercial purposes requires written permission.","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"000528312","url":"https://shiga-med.repo.nii.ac.jp/record/4486/files/000528312.pdf"},"version_id":"b21d4b08-3848-4302-92b7-cec9160999c0"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Intestinal myofibroblasts","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Antifibrotic therapy","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Transforming growth factor-β","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Epithelial-to-mesenchymal transition","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Molecular Basis of Intestinal Fibrosis in Inflammatory Bowel Disease","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Molecular Basis of Intestinal Fibrosis in Inflammatory Bowel Disease"}]},"item_type_id":"4","owner":"11","path":["228"],"pubdate":{"attribute_name":"公開日","attribute_value":"2023-05-16"},"publish_date":"2023-05-16","publish_status":"0","recid":"4486","relation_version_is_last":true,"title":["Molecular Basis of Intestinal Fibrosis in Inflammatory Bowel Disease"],"weko_creator_id":"11","weko_shared_id":-1},"updated":"2023-06-19T11:06:41.090333+00:00"}