{"created":"2023-06-19T10:44:05.948219+00:00","id":4477,"links":{},"metadata":{"_buckets":{"deposit":"7956940b-52f9-41ad-a6ce-54d66edb51fe"},"_deposit":{"created_by":11,"id":"4477","owners":[11],"pid":{"revision_id":0,"type":"depid","value":"4477"},"status":"published"},"_oai":{"id":"oai:shiga-med.repo.nii.ac.jp:00004477","sets":["30:261:262","30:62:231"]},"author_link":["7647","7911","9273","9378","9103","9102","7651","7929"],"item_4_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2023-03-10","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicVolumeNumber":"20","bibliographic_titles":[{},{"bibliographic_title":"Fluids and Barriers of the CNS","bibliographic_titleLang":"en"}]}]},"item_4_creator_3":{"attribute_name":"著者別名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"山田, 茂樹"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"平塚, 真之輔"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"野﨑, 和彦"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"渡邉, 嘉之"}],"nameIdentifiers":[{},{},{}]}]},"item_4_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_4_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background:\nIn the cerebrospinal fluid (CSF) dynamics, the pulsations of cerebral arteries and brain is considered the main driving force for the reciprocating bidirectional CSF movements. However, measuring these complex CSF movements on conventional flow-related MRI methods is difficult. We tried to visualize and quantify the CSF motion by using intravoxel incoherent motion (IVIM) MRI with low multi-b diffusion-weighted imaging. ","subitem_description_type":"Abstract"},{"subitem_description":"Methods:\nDiffusion-weighted sequence with six b values (0, 50, 100, 250, 500, and 1000 s/mm2) was performed on 132 healthy volunteers aged ≥ 20 years and 36 patients with idiopathic normal pressure hydrocephalus (iNPH). The healthy volunteers were divided into three age groups (< 40, 40 to < 60, and ≥ 60 years). In the IVIM analysis, the bi-exponential IVIM fitting method using the Levenberg-Marquardt algorithm was adapted. The average, maximum, and minimum values of ADC, D, D*, and fraction of incoherent perfusion (f) calculated by IVIM were quantitatively measured in 45 regions of interests in the whole ventricles and subarachnoid spaces. ","subitem_description_type":"Abstract"},{"subitem_description":"Results:\nCompared with healthy controls aged ≥ 60 years, the iNPH group had significantly lower mean f values in all the parts of the lateral and 3rd ventricles, whereas significantly higher mean f value in the bilateral foramina of Luschka. In the bilateral Sylvian fossa, which contain the middle cerebral bifurcation, the mean f values increased gradually with increasing age, whereas those were significantly lower in the iNPH group. In the 45 regions of interests, the f values in the bilateral foramina of Luschka were the most positively correlated with the ventricular size and indices specific to iNPH, whereas that in the anterior part of the 3rd ventricle was the most negatively correlated with the ventricular size and indices specific to iNPH. Other parameters of ADC, D, and D* were not significantly different between the two groups in any locations. ","subitem_description_type":"Abstract"},{"subitem_description":"Conclusions:\nThe f value on IVIM MRI is useful for evaluating small pulsatile complex motion of CSF throughout the intracranial CSF spaces. Patients with iNPH had significantly lower mean f values in the whole lateral ventricles and 3rd ventricles and significantly higher mean f value in the bilateral foramina of Luschka, compared with healthy controls aged ≥ 60 years. ","subitem_description_type":"Abstract"}]},"item_4_description_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Journal Article","subitem_description_type":"Other"}]},"item_4_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"BioMed Central Ltd"}]},"item_4_relation_10":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"36899412","subitem_relation_type_select":"PMID"}}]},"item_4_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"10.1186/s12987-023-00415-6"}],"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1186/s12987-023-00415-6","subitem_relation_type_select":"DOI"}}]},"item_4_relation_13":{"attribute_name":"PMCID","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"PMC9999497"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.ncbi.nlm.nih.gov/pmc/articles/pmc9999497/","subitem_relation_type_select":"URI"}}]},"item_4_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2023. The Author(s). "}]},"item_4_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2045-8118","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"YAMADA, Shigeki"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"HIRATSUKA, Shinnosuke"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"OTANI, Tomohiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"II, Satoshi"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"WADA, Shigeo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"OSHIMA, Marie"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"NOZAKI, Kazuhiko"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"WATANABE, Yoshiyuki"}],"nameIdentifiers":[{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-05-02"}],"displaytype":"detail","filename":"s12987-023-00415-6.pdf","filesize":[{"value":"2.8 MB"}],"format":"application/pdf","license_note":"This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"s12987-023-00415-6","url":"https://shiga-med.repo.nii.ac.jp/record/4477/files/s12987-023-00415-6.pdf"},"version_id":"48597df8-2872-4fbd-a8f6-6cd1c5d1777d"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Cerebrospinal fluid dynamics","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Idiopathic normal pressure hydrocephalus","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Aging","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Intravoxel incoherent motion","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Diffusion-weighted image","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Usefulness of intravoxel incoherent motion MRI for visualizing slow cerebrospinal fluid motion","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Usefulness of intravoxel incoherent motion MRI for visualizing slow cerebrospinal fluid motion"}]},"item_type_id":"4","owner":"11","path":["231","262"],"pubdate":{"attribute_name":"公開日","attribute_value":"2023-05-02"},"publish_date":"2023-05-02","publish_status":"0","recid":"4477","relation_version_is_last":true,"title":["Usefulness of intravoxel incoherent motion MRI for visualizing slow cerebrospinal fluid motion"],"weko_creator_id":"11","weko_shared_id":-1},"updated":"2023-06-19T11:06:51.587242+00:00"}