@article{oai:shiga-med.repo.nii.ac.jp:00004441,
 author = {影山, 進 and 沖中, 勇輝 and 和田, 晃典 and 永澤, 誠之 and 吉田, 哲也 and 成田, 充弘 and 河内, 明宏 and KAGEYAMA, Susumu and OKINAKA, Yuki and NISHIZAWA, Koji and YOSHIDA, Toru and ISHITOYA, Satoshi and SHICHIRI, Yasumasa and KIM , Chul Jang and IWATA, Tsuyoshi and YOKOKAWA, Ryusei and ARAI, Yutaka and NISHIKAWA, Zenkai and SOGA, Hiroki and Ushida, Hiroshi and SAKANO, Yuji and NAYA, Yoshio and WADA, Akinori and NAGASAWA, Masayuki and YOSHIDA, Tetsuya and NARITA, Mitsuhiro and KAWAUCHI, Akihiro},
 issue = {1},
 journal = {Molecular and Clinical Oncology},
 month = {Nov},
 note = {application/pdf, Prostate cancer is the most common genitourinary cancer in men. Population-based serum prostate-specific antigen (PSA) testing is used to screen men for the early detection of asymptomatic prostate cancer. The present study compared the features of patients with prostate cancer in Kusatsu City, the only municipality in Shiga Prefecture of Japan to implement organized PSA screening, with those in other municipalities. The target population for organized PSA screening by mail invitation was men ≥50 years. Patients were pathologically diagnosed via prostate biopsy because of elevated serum PSA. This multicenter observational study was subsequently conducted in 14 hospitals. The following information was extracted from patient records: age, reason for PSA testing, initial PSA level, Gleason score, clinical stage, and place of residence. Risk classification was defined as low, intermediate, high, and advanced. Each patient was stratified according to their city/town. A total of 984 patients diagnosed with prostate cancer in Shiga in 2012 and 2017 were analyzed, of which 955 (97%) were opportunistically tested, with the remaining 29 (3%) assessed by organized screening. In Kusatsu, 93 patients were diagnosed, of whom 26 (28%) were detected by organized screening. By contrast, only three of 891 patients (0.3%) were detected by organized screening in other municipalities. Of patients in Kusatsu, cases identified by opportunistic testing had a higher initial PSA value (P=0.010) than those identified by organized screening. However, patients detected through opportunistic testing in Kusatsu City were younger (P=0.034), had a lower PSA value (P=0.001), and improved risk classification (P<0.001) than those in other municipalities. It was concluded that more patients were diagnosed with early-stage cancer by organized PSA screening. Furthermore, population-based PSA screening in Kusatsu City may have indirectly affected early detection, even by opportunistic testing., Journal Article},
 title = {Population‑based prostate‑specific antigen screening for prostate cancer may have an indirect effect on early detection through opportunistic testing in Kusatsu City, Shiga, Japan},
 volume = {18},
 year = {2022}
}