{"created":"2023-06-19T10:44:02.449665+00:00","id":4411,"links":{},"metadata":{"_buckets":{"deposit":"1d837476-2734-4ac0-aa19-3d7a87676b37"},"_deposit":{"created_by":11,"id":"4411","owners":[11],"pid":{"revision_id":0,"type":"depid","value":"4411"},"status":"published"},"_oai":{"id":"oai:shiga-med.repo.nii.ac.jp:00004411","sets":["30:50:193"]},"author_link":["3728","2767","2737","7692","2502","6625","8491","7250"],"item_4_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-12-21","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"12","bibliographicVolumeNumber":"17","bibliographic_titles":[{},{"bibliographic_title":"PLoS ONE","bibliographic_titleLang":"en"}]}]},"item_4_creator_3":{"attribute_name":"著者別名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"一山, 悠介"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"松本, 理子"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"小幡, 峻平"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"澤田, 修"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"西信, 良嗣"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"柿木, 雅志"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"澤田, 智子"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"大路, 正人"}],"nameIdentifiers":[{},{}]}]},"item_4_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_4_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Purpose:\nTo assess the interaction between ranibizumab, aflibercept, and mouse vascular endothelial growth factor (VEGF), both in vivo and in vitro. ","subitem_description_type":"Abstract"},{"subitem_description":"Methods:\nIn vivo, the effect of intravitreal injection of ranibizumab and aflibercept on oxygen induced retinopathy (OIR) and the effect of multiple intraperitoneal injections of ranibizumab and aflibercept on neonatal mice were assessed. In vitro, the interaction of mouse VEGF-A with aflibercept or ranibizumab as the primary antibody was analyzed by Western blot. ","subitem_description_type":"Abstract"},{"subitem_description":"Results:\nIn both experiments using intravitreal injections in OIR mice and multiple intraperitoneal injections in neonatal mice, anti-VEGF effects were observed with aflibercept, but not with ranibizumab. Western blot analysis showed immunoreactive bands for mouse VEGF-A in the aflibercept-probed blot, but not in the ranibizumab-probed blot. ","subitem_description_type":"Abstract"},{"subitem_description":"Conclusions:\nAflibercept but not ranibizumab interacts with mouse VEGF, both in vivo and in vitro. When conducting experiments using anti-VEGF drugs in mice, aflibercept is suitable, but ranibizumab is not. ","subitem_description_type":"Abstract"}]},"item_4_description_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Journal Article","subitem_description_type":"Other"}]},"item_4_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Public Library of Science"}]},"item_4_relation_10":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"36542626","subitem_relation_type_select":"PMID"}}]},"item_4_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"10.1371/journal.pone.0278951"}],"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1371/journal.pone.0278951","subitem_relation_type_select":"DOI"}}]},"item_4_relation_13":{"attribute_name":"PMCID","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"PMC9770341"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.ncbi.nlm.nih.gov/pmc/articles/pmc9770341/","subitem_relation_type_select":"URI"}}]},"item_4_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":" © 2022 Ichiyama et al. "}]},"item_4_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1932-6203","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"ICHIYAMA, Yusuke"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"MATSUMOTO, Riko"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"OBATA, Shumpei"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"SAWADA, Osamu"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"SAISHIN, Yoshitsugu"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"KAKINOKI, Masashi"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"SAWADA, Tomoko"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"OHJI, Masahito"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-01-25"}],"displaytype":"detail","filename":"journal.pone.0278951.pdf","filesize":[{"value":"2.6 MB"}],"format":"application/pdf","license_note":"This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"journal.pone.0278951","url":"https://shiga-med.repo.nii.ac.jp/record/4411/files/journal.pone.0278951.pdf"},"version_id":"7915590a-2c2e-4d0e-bfb1-44957f0ed44d"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Assessment of mouse VEGF neutralization by ranibizumab and aflibercept","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Assessment of mouse VEGF neutralization by ranibizumab and aflibercept"}]},"item_type_id":"4","owner":"11","path":["193"],"pubdate":{"attribute_name":"公開日","attribute_value":"2023-01-25"},"publish_date":"2023-01-25","publish_status":"0","recid":"4411","relation_version_is_last":true,"title":["Assessment of mouse VEGF neutralization by ranibizumab and aflibercept"],"weko_creator_id":"11","weko_shared_id":-1},"updated":"2023-06-19T11:08:54.875623+00:00"}