{"created":"2023-06-19T10:44:01.491062+00:00","id":4392,"links":{},"metadata":{"_buckets":{"deposit":"d3502166-5073-4de0-88b7-e2fd2346d857"},"_deposit":{"created_by":11,"id":"4392","owners":[11],"pid":{"revision_id":0,"type":"depid","value":"4392"},"status":"published"},"_oai":{"id":"oai:shiga-med.repo.nii.ac.jp:00004392","sets":["30:202:203","30:403:404","30:445:446","30:447:448","30:52:282"]},"author_link":["8430","3394","8707","450","7211","56","7208","531","550"],"item_4_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-11-29","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicVolumeNumber":"12","bibliographic_titles":[{},{"bibliographic_title":"Scientific Reports","bibliographic_titleLang":"en"}]}]},"item_4_creator_3":{"attribute_name":"著者別名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"白井, 悠貴"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"岡野, 純子"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"仲川, 孝彦"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"樫, 美和子"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"中江, 由希"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"荒川, 篤宏"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"越沼, 伸也"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"山本, 学"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"小島, 秀人"}],"nameIdentifiers":[{},{},{}]}]},"item_4_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_4_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Deep skin wounds with periosteal defects, frequently caused by traffic accidents or radical dissection, are refractory. Transplant surgery is frequently performed, but patients are subjected to stress for long operation periods, the sacrifice of donor regions, or several complications, such as flap necrosis or intractable ulcers. Even if the defects are covered, a scar composed of fibrous tissue remains in the body, which can cause itching, dysesthesia, or repeated ulcers because of the lack of distribution of peripheral nerves or hair follicles. Thus, treatments with the aim of regenerating lost tissue for deep wounds with periosteal defects are needed. Here, we show that the use of gelatin sponges (GS), which have been used as haemostatic materials in clinical practice, allowed the regeneration of heterogeneous tissues, including periosteum, skin, and skin appendages, when used as scaffolds in deep wounds with periosteal defects in rats. Bone marrow transplantation in rats revealed the mechanism by which the microenvironment provided by GS enabled bone marrow-derived cells (BMDCs) to form a vascular niche, followed by regeneration of the periosteum, skin, or skin appendages such as hair follicles by local cells. Our findings demonstrated that vascular niche formation provided by BMDCs is crucial for heterogeneous tissue regeneration. ","subitem_description_type":"Abstract"}]},"item_4_description_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Journal Article","subitem_description_type":"Other"}]},"item_4_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer Nature"}]},"item_4_relation_10":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"36446886","subitem_relation_type_select":"PMID"}}]},"item_4_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"10.1038/s41598-022-24957-1"}],"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1038/s41598-022-24957-1","subitem_relation_type_select":"DOI"}}]},"item_4_relation_13":{"attribute_name":"PMCID","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"PMC9708684"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.ncbi.nlm.nih.gov/pmc/articles/pmc9708684/","subitem_relation_type_select":"URI"}}]},"item_4_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2022. The Author(s). "}]},"item_4_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2045-2322","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"SHIRAI, Yuuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"OKANO, Junko"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"NAKAGAWA, Takahiko"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"KATAGI, Miwako"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"NAKAE, Yuki"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"ARAKAWA, Atsuhiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"KOSHINUMA, Shinya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"YAMAMOTO, Gaku"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"KOJIMA, Hideto"}],"nameIdentifiers":[{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-12-14"}],"displaytype":"detail","filename":"s41598-022-24957-1.pdf","filesize":[{"value":"2.8 MB"}],"format":"application/pdf","license_note":" This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"s41598-022-24957-1","url":"https://shiga-med.repo.nii.ac.jp/record/4392/files/s41598-022-24957-1.pdf"},"version_id":"eca7b112-08df-44ea-9805-ae0a947a48c1"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-12-14"}],"displaytype":"detail","filename":"s41598-022-24957-1_Supplementary Information.pdf","filesize":[{"value":"287.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"s41598-022-24957-1_Supplementary Information","url":"https://shiga-med.repo.nii.ac.jp/record/4392/files/s41598-022-24957-1_Supplementary Information.pdf"},"version_id":"1a6359fc-2745-4dd5-89ef-d2cbd3b9dad1"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Biochemistry","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Immunochemistry","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Regeneration","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Skin diseases","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Stem-cell niche","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Stem cells","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Trauma","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Bone marrow-derived vasculogenesis leads to scarless regeneration in deep wounds with periosteal defects","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Bone marrow-derived vasculogenesis leads to scarless regeneration in deep wounds with periosteal defects"}]},"item_type_id":"4","owner":"11","path":["203","282","404","446","448"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-12-14"},"publish_date":"2022-12-14","publish_status":"0","recid":"4392","relation_version_is_last":true,"title":["Bone marrow-derived vasculogenesis leads to scarless regeneration in deep wounds with periosteal defects"],"weko_creator_id":"11","weko_shared_id":-1},"updated":"2023-06-19T11:09:23.802364+00:00"}