{"created":"2023-06-19T10:44:00.048015+00:00","id":4366,"links":{},"metadata":{"_buckets":{"deposit":"29330f84-0c13-4f5b-96ce-2f9013485d4c"},"_deposit":{"created_by":11,"id":"4366","owners":[11],"pid":{"revision_id":0,"type":"depid","value":"4366"},"status":"published"},"_oai":{"id":"oai:shiga-med.repo.nii.ac.jp:00004366","sets":["30:46:84"]},"author_link":["8899","7867","8655","1939","8898","297","2820","7866","7507","2814","7865"],"item_4_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-09","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"9","bibliographicPageEnd":"1503","bibliographicPageStart":"1496","bibliographicVolumeNumber":"24","bibliographic_titles":[{},{"bibliographic_title":"Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology","bibliographic_titleLang":"en"}]}]},"item_4_creator_3":{"attribute_name":"著者別名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"福山, 恵"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"堀江, 稔"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"加藤, 浩一"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"澤山, 裕一"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"中川, 義久"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"大野, 聖子"}],"nameIdentifiers":[{},{},{}]}]},"item_4_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Aims:\nSchool-based routine screenings of electrocardiograms (ECGs) have been performed upon admission to primary school (PS), junior high school (JHS), and high school (HS) in Japan. Though ECGs with prolonged QT intervals are occasionally found, the role of regular ECG screening tests in identifying long QT syndrome (LQTS) remains to be determined. We investigated the usefulness of the ECG screenings by comparing the results of genetic tests between students who showed QT-prolongation in the screenings and patients with LQTS. ","subitem_description_type":"Abstract"},{"subitem_description":"Methods and results:\nWe genetically screened 341 students (106 PS, 173 JHS, and 62 HS). Of these, 230 subjects showed QT-prolongation during regular screenings (S-S group), and the other 111 patients were clinically consulted with suspected LQTS by paediatricians (C-C group). Genotype-phenotype relationships were compared between the two groups. The positive rates in the genetic tests were comparable among the two groups; however, symptomatic subjects were significantly fewer in the S-S group than the C-C group (3% vs. 70%). Compared to the genotype-negative subjects, the positive subjects showed significantly longer QTc (P < 0.0001) and more frequently presented LQTS risk scores with ≥3.5 points (P < 0.0001). Lethal arrhythmic events (LAE) occurred only in the C-C group; 18 subjects experienced LAE and 83% of them were found to carry variant(s) in the LQTS-related genes.","subitem_description_type":"Abstract"},{"subitem_description":"Conclusion:\nThe school-based ECG screenings are effective in identifying young patients with LQTS who require genetic analysis. If individuals are screened at a younger age, we can identify patients at risk earlier and provide preventative treatments. ","subitem_description_type":"Abstract"}]},"item_4_description_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Journal Article","subitem_description_type":"Other"}]},"item_4_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Oxford University Press"}]},"item_4_relation_10":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"35060598","subitem_relation_type_select":"PMID"}}]},"item_4_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"10.1093/europace/euab320"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1093/europace/euab320","subitem_relation_type_select":"DOI"}}]},"item_4_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Published on behalf of the European Society of Cardiology. All rights reserved."},{"subitem_rights":"© The Author(s) 2022. "},{"subitem_rights":" For permissions, please email: journals.permissions@oup.com. "}]},"item_4_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1532-2092","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"FUKUYAMA, Megumi"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"HORIE, Minoru"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"AOKI, Hisaaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"OZAWA, Junichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"KATO, Koichi"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"SAWAYAMA, Yuichi"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"TANAKA-MIZUNO, Sachiko"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"MAKIYAMA, Takeru"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"YOSHINAGA, Masao"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"NAKAGAWA, Yoshihisa"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"OHNO, Seiko"}],"nameIdentifiers":[{},{},{}]}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Long QT syndrome","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Genetic testing","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"School-based electrocardiogram screening","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Arrhythmia","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"School-based routine screenings of electrocardiograms for the diagnosis of long QT syndrome.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"School-based routine screenings of electrocardiograms for the diagnosis of long QT syndrome."}]},"item_type_id":"4","owner":"11","path":["84"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-11-02"},"publish_date":"2022-11-02","publish_status":"0","recid":"4366","relation_version_is_last":true,"title":["School-based routine screenings of electrocardiograms for the diagnosis of long QT syndrome."],"weko_creator_id":"11","weko_shared_id":-1},"updated":"2023-06-19T11:10:01.503979+00:00"}