{"created":"2023-06-19T10:43:58.421125+00:00","id":4329,"links":{},"metadata":{"_buckets":{"deposit":"43f5c954-acc7-41dc-9291-49452edf8f5a"},"_deposit":{"created_by":11,"id":"4329","owners":[11],"pid":{"revision_id":0,"type":"depid","value":"4329"},"status":"published"},"_oai":{"id":"oai:shiga-med.repo.nii.ac.jp:00004329","sets":["30:46:84"]},"author_link":["9132","7867","9135","9126","9130","9136","9139","9124","9140","9131","9127","9134","9133","9129","9137","9138","9125","667","9128"],"item_4_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"9","bibliographicPageEnd":"1361","bibliographicPageStart":"1352","bibliographicVolumeNumber":"86","bibliographic_titles":[{},{"bibliographic_title":"Circulation journal : official journal of the Japanese Circulation Society","bibliographic_titleLang":"en"}]}]},"item_4_creator_2":{"attribute_name":"著者(ヨミ)","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"中川, 義久"}],"nameIdentifiers":[{},{}]}]},"item_4_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"pdf","subitem_description_type":"Other"}]},"item_4_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background:\nIn PENDULUM mono, Japanese patients with high bleeding risk (HBR) received short-term dual antiplatelet therapy (DAPT) followed by single antiplatelet therapy (SAPT) with prasugrel after percutaneous coronary intervention (PCI). One-year data from PENDULUM mono showed better outcomes with prasugrel monotherapy after short-term DAPT compared with matched patients in the PENDULUM registry with longer DAPT durations according to guidelines at that time. This study presents 2-year results.Methods and Results: We compared 24-month data from PENDULUM mono (n=1,107; de-escalation strategy group) and the PENDULUM registry (n=2,273; conventional strategy group); both were multicenter, non-interventional, prospective registry studies, using the inverse probability of treatment weighting (IPTW) method. In the PENDULUM mono group, the cumulative incidence of clinically relevant bleeding (CRB) at 24 months post-PCI (primary endpoint) was 6.8%, and that of major adverse cardiac and cerebrovascular events (MACCE) was 8.9%. After IPTW adjustment, the cumulative incidence of CRB was 5.8% and 7.2% in PENDULUM mono and the PENDULUM registry, respectively (hazard ratio [HR] 0.77; 95% confidence interval [CI] 0.57-1.04; P=0.086), and that of MACCE was 8.0% and 9.5%, respectively (HR 0.77; 95% CI 0.59-1.01; P=0.061). ","subitem_description_type":"Abstract"},{"subitem_description":"Conclusions:\nJapanese PCI patients with HBR prescribed prasugrel SAPT after short-term DAPT had a lower ischemic event risk than those prescribed long-term DAPT, and this was particularly relevant for ischemic events after 1 year. ","subitem_description_type":"Abstract"}]},"item_4_description_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Journal Article","subitem_description_type":"Other"}]},"item_4_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"The Japanese Circulation Society"}]},"item_4_publisher_34":{"attribute_name":"別言語の出版者","attribute_value_mlt":[{"subitem_publisher":"日本循環器学会"}]},"item_4_relation_10":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"35584932","subitem_relation_type_select":"PMID"}}]},"item_4_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"10.1253/circj.cj-21-1004"}],"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1253/circj.cj-21-1004","subitem_relation_type_select":"DOI"}}]},"item_4_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2022, THE JAPANESE CIRCULATION SOCIETY"}]},"item_4_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1347-4820","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"NAKAGAWA, Yoshihisa"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"KADOTA, Kazushige"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"NAKAO, Koichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"SHITE, Junya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"YOKOI, Hiroyoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"KOZUMA, Ken"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"TANABE, Kengo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"AKASAKA, Takashi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"SHINKE, Toshiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"UENO, Takafumi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"HIRAYAMA, Atsushi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"UEMURA, Shiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"IIJIMA, Raisuke"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"HARADA, Atsushi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"KURODA, Takeshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"TAKITA, Atsushi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"MURAKAMI, Yoshitaka"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"SAITO, Shigeru"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"NAKAMURA, Masato"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-09-20"}],"displaytype":"detail","filename":"circj.CJ-21-1004.pdf","filesize":[{"value":"1.7 MB"}],"format":"application/pdf","license_note":"This article is licensed under a Creative Commons [Attribution-\nNonCommercial-NoDerivatives 4.0 International] license.\nhttps://creativecommons.org/licenses/by-nc-nd/4.0/","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"circj.CJ-21-1004","url":"https://shiga-med.repo.nii.ac.jp/record/4329/files/circj.CJ-21-1004.pdf"},"version_id":"d550c166-9d8b-44a1-aecd-85059e3149ff"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-09-20"}],"displaytype":"detail","filename":"circj.CJ-21-1004_Supplementary Files.pdf","filesize":[{"value":"626.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"circj.CJ-21-1004_Supplementary Files","url":"https://shiga-med.repo.nii.ac.jp/record/4329/files/circj.CJ-21-1004_Supplementary Files.pdf"},"version_id":"60374f01-242b-4c96-a41e-127c508b48de"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Bleeding risk","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Japan","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Percutaneous coronary intervention","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Prasugrel","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Single antiplatelet therapy","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Early P2Y 12 Inhibitor Single Antiplatelet Therapy for High-Bleeding Risk Patients After Stenting - PENDULUM Mono 24-Month Analysis","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Early P2Y 12 Inhibitor Single Antiplatelet Therapy for High-Bleeding Risk Patients After Stenting - PENDULUM Mono 24-Month Analysis"}]},"item_type_id":"4","owner":"11","path":["84"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-09-20"},"publish_date":"2022-09-20","publish_status":"0","recid":"4329","relation_version_is_last":true,"title":["Early P2Y 12 Inhibitor Single Antiplatelet Therapy for High-Bleeding Risk Patients After Stenting - PENDULUM Mono 24-Month Analysis"],"weko_creator_id":"11","weko_shared_id":-1},"updated":"2023-06-19T11:11:21.043058+00:00"}