@article{oai:shiga-med.repo.nii.ac.jp:00004329,
 author = {中川, 義久 and NAKAGAWA, Yoshihisa and KADOTA, Kazushige and NAKAO, Koichi and SHITE, Junya and YOKOI, Hiroyoshi and KOZUMA, Ken and TANABE, Kengo and AKASAKA, Takashi and SHINKE, Toshiro and UENO, Takafumi and HIRAYAMA, Atsushi and UEMURA, Shiro and IIJIMA, Raisuke and HARADA, Atsushi and KURODA, Takeshi and TAKITA, Atsushi and MURAKAMI, Yoshitaka and SAITO, Shigeru and NAKAMURA, Masato},
 issue = {9},
 journal = {Circulation journal : official journal of the Japanese Circulation Society},
 month = {},
 note = {pdf, Background:
In PENDULUM mono, Japanese patients with high bleeding risk (HBR) received short-term dual antiplatelet therapy (DAPT) followed by single antiplatelet therapy (SAPT) with prasugrel after percutaneous coronary intervention (PCI). One-year data from PENDULUM mono showed better outcomes with prasugrel monotherapy after short-term DAPT compared with matched patients in the PENDULUM registry with longer DAPT durations according to guidelines at that time. This study presents 2-year results.Methods and Results: We compared 24-month data from PENDULUM mono (n=1,107; de-escalation strategy group) and the PENDULUM registry (n=2,273; conventional strategy group); both were multicenter, non-interventional, prospective registry studies, using the inverse probability of treatment weighting (IPTW) method. In the PENDULUM mono group, the cumulative incidence of clinically relevant bleeding (CRB) at 24 months post-PCI (primary endpoint) was 6.8%, and that of major adverse cardiac and cerebrovascular events (MACCE) was 8.9%. After IPTW adjustment, the cumulative incidence of CRB was 5.8% and 7.2% in PENDULUM mono and the PENDULUM registry, respectively (hazard ratio [HR] 0.77; 95% confidence interval [CI] 0.57-1.04; P=0.086), and that of MACCE was 8.0% and 9.5%, respectively (HR 0.77; 95% CI 0.59-1.01; P=0.061)., Conclusions:
Japanese PCI patients with HBR prescribed prasugrel SAPT after short-term DAPT had a lower ischemic event risk than those prescribed long-term DAPT, and this was particularly relevant for ischemic events after 1 year., Journal Article},
 pages = {1352--1361},
 title = {Early P2Y 12 Inhibitor Single Antiplatelet Therapy for High-Bleeding Risk Patients After Stenting - PENDULUM Mono 24-Month Analysis},
 volume = {86},
 year = {2022}
}