{"created":"2023-06-19T10:43:56.228531+00:00","id":4288,"links":{},"metadata":{"_buckets":{"deposit":"63b02024-f66b-4f0c-b0e6-e3f6f88ac0b2"},"_deposit":{"created_by":11,"id":"4288","owners":[11],"pid":{"revision_id":0,"type":"depid","value":"4288"},"status":"published"},"_oai":{"id":"oai:shiga-med.repo.nii.ac.jp:00004288","sets":["30:204:205","30:261:262","77:400:401"]},"author_link":["210","7911","9073","9074","7963","7961","784","9072"],"item_4_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-06-28","bibliographicIssueDateType":"Issued"},"bibliographic_titles":[{},{"bibliographic_title":"Japanese Journal of Radiology","bibliographic_titleLang":"en"}]}]},"item_4_creator_3":{"attribute_name":"著者別名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"岬, 沙耶香"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"村田, 聡"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"下地, みゆき"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"青木, 健"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"渡邉, 嘉之"}],"nameIdentifiers":[{},{},{}]}]},"item_4_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"pdf","subitem_description_type":"Other"}]},"item_4_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Purpose:\nTreatments for metastatic human epidermal growth factor receptor 2 (HER2)-positive tumors are improving but remain inadequate. We investigated activating antitumor immune response by combining radiation therapy with immune checkpoint inhibitors using mouse tumors overexpressing HER2, a pivotal driver oncogenic antigen, to develop new immunotherapies for metastatic HER2-positive tumors. ","subitem_description_type":"Abstract"},{"subitem_description":"Materials and methods:\nNT2.5 cells were inoculated into the two mammary fat pads of FVB/N mice, which were divided into four groups: no treatment (Non), anti-PD-1 and anti-CTLA4 antibodies (P1C4), irradiation of the large tumor (Rad), and combination (R + P1C4) groups. Tumor growth, immunostaining of tumor-infiltrating lymphocytes, and the proportion of HER2-tumor antigen-specific CD8-positive T cells in the spleen and tumor-infiltrating lymphocytes were analyzed. ","subitem_description_type":"Abstract"},{"subitem_description":"Results:\nIn the Rad group, unirradiated and irradiated tumors shrank after treatment. Besides the directly irradiated tumors, the unirradiated tumors in the R + P1C4 group shrank the most. In the unirradiated tumors, CD8-positive T cells and FOXP3-positive T cells accumulated significantly more in the R + P1C4 group than in the P1C4 and the Rad groups (all p < 0.001). CD4-positive helper T cells accumulated significantly more in the R + P1C4 group than in the Rad group (p < 0.05), but this was not significantly different from the P1C4 group. HER2-specific CD8-positive T cells in the spleen and tumor-infiltrating lymphocytes were significantly increased in the R + P1C4 group compared to the P1C4 and Rad groups (all p < 0.0001). ","subitem_description_type":"Abstract"},{"subitem_description":"Conclusion:\nIrradiation of HER2-positive tumors induced an antitumor immune effect against the unirradiated tumor, which was enhanced by the combined use of immune checkpoint inhibitors and was mediated by enhanced recruitment of HER2-tumor antigen-specific cytotoxic T lymphocytes at the tumor site in an HER2-positive mouse tumor model. Harnessing the distant antitumor immune response induced by the combination of radiation therapy and immune checkpoint inhibitors could be a promising treatment strategy for metastatic HER2-positive tumors. ","subitem_description_type":"Abstract"}]},"item_4_description_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Journal Article","subitem_description_type":"Other"}]},"item_4_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer Nature"}]},"item_4_relation_10":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"35763240","subitem_relation_type_select":"PMID"}}]},"item_4_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"10.1007/s11604-022-01303-z"}],"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1007/s11604-022-01303-z","subitem_relation_type_select":"DOI"}}]},"item_4_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2022. The Author(s). "}]},"item_4_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1867-1071","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"MISAKI, Sayaka"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"MURATA, Satoshi"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"SHIMOJI, Miyuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"IWAI, Takayasu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"SIHOMBING, Andreas Michael"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"AOKI, Ken"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"TAKAHASHI, Yutaka"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"WATANABE, Yoshiyuki"}],"nameIdentifiers":[{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-07-14"}],"displaytype":"detail","filename":"s11604-022-01303-z.pdf","filesize":[{"value":"6.6 MB"}],"format":"application/pdf","license_note":"This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation,\ndistribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are\nincluded in the article's Creative Commons licence, unless indicated\notherwise in a credit line to the material. If material is not included in\nthe article's Creative Commons licence and your intended use is not\npermitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit\nhttp://creativecommons.org/licenses/by/4.0/.","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"s11604-022-01303-z","url":"https://shiga-med.repo.nii.ac.jp/record/4288/files/s11604-022-01303-z.pdf"},"version_id":"378dc488-76b7-47e8-a579-01d99c6ffa3c"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Radioimmunotherapy","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Tumor antigen-specific CD8-positive T-lymphocyte","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Cytotoxic T-lymphocyte","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Immune checkpoint inhibitor","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Abscopal effect","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Enhancement of antitumor immune response by radiation therapy combined with dual immune checkpoint inhibitor in a metastatic model of HER2-positive murine tumor","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Enhancement of antitumor immune response by radiation therapy combined with dual immune checkpoint inhibitor in a metastatic model of HER2-positive murine tumor"}]},"item_type_id":"4","owner":"11","path":["205","262","401"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-07-14"},"publish_date":"2022-07-14","publish_status":"0","recid":"4288","relation_version_is_last":true,"title":["Enhancement of antitumor immune response by radiation therapy combined with dual immune checkpoint inhibitor in a metastatic model of HER2-positive murine tumor"],"weko_creator_id":"11","weko_shared_id":-1},"updated":"2023-06-19T11:12:27.663641+00:00"}