{"created":"2023-06-19T10:43:51.663728+00:00","id":4204,"links":{},"metadata":{"_buckets":{"deposit":"67702f21-9d48-4053-8e54-40462ab45872"},"_deposit":{"created_by":11,"id":"4204","owners":[11],"pid":{"revision_id":0,"type":"depid","value":"4204"},"status":"published"},"_oai":{"id":"oai:shiga-med.repo.nii.ac.jp:00004204","sets":["30:62:231"]},"author_link":["2107","184"],"item_4_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-04-15","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"185","bibliographicPageStart":"177","bibliographicVolumeNumber":"62","bibliographic_titles":[{},{"bibliographic_title":"Neurologia medico-chirurgica","bibliographic_titleLang":"en"}]}]},"item_4_creator_3":{"attribute_name":"著者別名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"中洲, 敏"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"中洲, 庸子"}],"nameIdentifiers":[{},{}]}]},"item_4_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"pdf","subitem_description_type":"Other"}]},"item_4_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Malignant progression of diffuse low-grade glioma (LGG) is a critical event affecting patient survival; however, the incidence and related factors have been inconsistent in literature. According to the PRISMA guidelines, we systematically reviewed articles from 2009, meta-analyzed the incidence of malignant progression, and clarified factors related to the transformation. Forty-one articles were included in this study (n = 7,122; n, number of patients). We identified two definitions of malignant progression: histologically proven (Htrans) and clinically defined (Ctrans). The malignant progression rate curves of Htrans and Ctrans were almost in parallel when constructed from the results of meta-regression by the mean follow-up time. The true transformation rate was supposed to lie between the two curves, approximately 40% at the 10-year mean follow-up. Risk of malignant progression was evaluated using hazard ratio (HR). Pooled HRs were significantly higher in tumors with a larger pre- and postoperative tumor volume, lower degree of resection, and notable preoperative contrast enhancement on magnetic resonance imaging than in others. Oligodendroglial histology and IDH mutation (IDHm) with 1p/19q codeletion (Codel) also significantly reduced the HRs. Using Kaplan-Meier curves from eight studies with molecular data, we extracted data and calculated the 10-year malignant progression-free survival (10yMPFS). The 10yMPFS in patients with IDHm without Codel was 30.4% (95% confidence interval [95% CI]: 22.2-39.0) in Htrans and 38.3% (95% CI: 32.3-44.3) in Ctrans, and that with IDHm with Codel was 71.7% (95% CI: 61.7-79.5) in Htrans and 62.5% (95% CI: 55.9-68.5) in Ctrans. The effect of adjuvant radiotherapy or chemotherapy could not be determined.","subitem_description_type":"Abstract"}]},"item_4_description_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Journal Article","subitem_description_type":"Other"}]},"item_4_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"The Japan Neurosurgical Society"}]},"item_4_publisher_34":{"attribute_name":"別言語の出版者","attribute_value_mlt":[{"subitem_publisher":"日本脳神経外科学会 "}]},"item_4_relation_10":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"35197400","subitem_relation_type_select":"PMID"}}]},"item_4_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"10.2176/jns-nmc.2021-0313"}],"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.2176/jns-nmc.2021-0313","subitem_relation_type_select":"DOI"}}]},"item_4_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2022 The Japan Neurosurgical Society"}]},"item_4_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1349-8029","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"NAKASU, Satoshi"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"NAKASU, Yoko"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-05-02"}],"displaytype":"detail","filename":"jns-nmc.2021-0313.pdf","filesize":[{"value":"432.6 kB"}],"format":"application/pdf","license_note":"This work is licensed under a Creative Commons Attribution-\nNonCommercial-NoDerivatives International License.","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"jns-nmc.2021-0313","url":"https://shiga-med.repo.nii.ac.jp/record/4204/files/jns-nmc.2021-0313.pdf"},"version_id":"c72053b8-5b1f-47af-805b-e13b5968cbaf"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"low-grade glioma","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"diffuse astrocytoma","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"oligodendroglioma","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"malignant transformation","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Malignant Progression of Diffuse Low-grade Gliomas : A Systematic Review and Meta-analysis on Incidence and Related Factors.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Malignant Progression of Diffuse Low-grade Gliomas : A Systematic Review and Meta-analysis on Incidence and Related Factors."}]},"item_type_id":"4","owner":"11","path":["231"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-05-02"},"publish_date":"2022-05-02","publish_status":"0","recid":"4204","relation_version_is_last":true,"title":["Malignant Progression of Diffuse Low-grade Gliomas : A Systematic Review and Meta-analysis on Incidence and Related Factors."],"weko_creator_id":"11","weko_shared_id":-1},"updated":"2023-06-19T11:16:07.432169+00:00"}