@article{oai:shiga-med.repo.nii.ac.jp:00004201,
 author = {和田, 康宏 and 中島, 滋美 and 森, 直子 and 茶谷, 玲奈 and 大原, 真理子 and 藤井, 誠 and 長谷川, 大 and 早藤, 清行 and 九嶋, 亮治 and WADA, Yasuhiro and NAKAJIMA, Shigemi and MORI, Naoko and TAKEMURA, Shizuki and CHATANI, Rena and OHARA, Mariko and FUJII, Makoto and HASEGAWA, Hiroshi and HAYAFUJI, Kiyoyuki and KUSHIMA, Ryoji and MURAKAMI, Kazunari},
 issue = {1},
 journal = {BMC Gastroenterology},
 month = {Apr},
 note = {pdf, Background:
The aims of the present study are to evaluate non-invasive screening tests for autoimmune gastritis (AIG) and re-evaluate histopathological classification., Methods:
We screened candidates of AIG in JCHO Shiga Hospital between May 2012 and January 2020. The screening criteria were as follows: endoscopic O-p atrophy with Updated Kimura-Takemoto classification, 3 + pepsinogen (PG) test, low serum vitamin B12 or elevated serum gastrin with positive anti-parietal cell (PC) or intrinsic factor antibodies. We evaluated the screening criteria in the patients who were histopathologically confirmed as AIG, and re-evaluated histopathological staging in clinical aspects., Results:
Twenty-two of 28 (78.6%) patients who met the screening criteria were histopathologically confirmed as AIG. Common clinical findings in the AIG patients were 10 × or greater anti-PC antibody, elevated serum gastrin greater than 172 pg/mL and endoscopic atrophy O-1 or greater. The areas under the curve of PG I, PG II and PG I/II ratio were 0.81, 0.29 and 0.98, respectively. Among histopathologically confirmed AIG patients, 4 and 18 patients were histopathologically classified into florid and end stages, respectively, while no patients into early stage. We could not find a significant difference between florid and end stages in the screening items studied., Conclusions:
Florid and end stages in histopathological classification are both advanced-stage AIG in clinical aspects. Our screening criteria without biopsy are applicable to screen clinically-advanced AIG with 78.6% positive predictive value. PG I and PG I/II ratio may be useful to screen AIG. However, we may need other criteria to screen early stage of AIG., Journal Article},
 title = {Evaluation of screening tests for autoimmune gastritis in histopathologically confirmed Japanese patients, and re-evaluation of histopathological classification.},
 volume = {22},
 year = {2022}
}