{"created":"2023-06-19T10:43:51.016837+00:00","id":4188,"links":{},"metadata":{"_buckets":{"deposit":"322263fd-e32d-41a2-85c2-8ccb3c101443"},"_deposit":{"created_by":11,"id":"4188","owners":[11],"pid":{"revision_id":0,"type":"depid","value":"4188"},"status":"published"},"_oai":{"id":"oai:shiga-med.repo.nii.ac.jp:00004188","sets":["19:410:411","19:412:413","30:202:203","30:261:262","30:44:71","30:59:221"]},"author_link":["2935","2849","7176","2433","3536","3054","7178","7970","632","8951","137","7507","633","538","8952","6389","7179"],"item_4_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-02-15","bibliographicIssueDateType":"Issued"},"bibliographicVolumeNumber":"186","bibliographic_titles":[{},{"bibliographic_title":"Diabetes research and clinical practice","bibliographic_titleLang":"en"}]}]},"item_4_creator_3":{"attribute_name":"著者別名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"堀部, 佳代"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"森野, 勝太郎"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"宮澤, 伊都子"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"近藤, 慶子"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"佐藤, 大介"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"大橋, 夏子"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"井田, 昌吾"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"柳町, 剛司"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"吉村, 雅寛"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"井藤, 隆太"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"村田, 喜代史"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"三浦, 克之"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"有馬, 久富"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"藤田, 征弘"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"卯木, 智"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"前川, 聡"}],"nameIdentifiers":[{},{},{}]}]},"item_4_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"pdf","subitem_description_type":"Other"}]},"item_4_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Aim:\nWe aimed to determine whether SGLT2 inhibitor dapagliflozin treatment affects body composition and amino acid (AA) metabolism. ","subitem_description_type":"Abstract"},{"subitem_description":"Methods:\nFifty-two overweight patients treated by oral antidiabetic agents were randomly assigned to dapagliflozin (Dapa) or a standard treatment (Con) and followed for 24 weeks. The primary outcome was the change in body mass (BM) between baseline and week 24. Body composition, intrahepatic triglyceride (IHTG) content, and plasma AA concentrations were examined as secondary outcomes. ","subitem_description_type":"Abstract"},{"subitem_description":"Results:\nThe change in BM was significantly larger in the Dapa than in the Con group, with a difference in the mean change of -1.72 kg (95 %CI: -2.85, -0.59; P = 0.004) between the groups. Total fat mass was reduced by dapagliflozin treatment, but fat-free mass was maintained. IHTG content was significantly reduced in the Dapa than in the Con (P = 0.033). Changes in AAs showed small differences between the groups, but only serine concentrations were significantly reduced in the Dapa. Intra-group analysis showed that positive associations were observed between changes in branched chain AA concentrations and body composition only in the Dapa. ","subitem_description_type":"Abstract"},{"subitem_description":"Conclusions:\nDapagliflozin treatment causes a reduction in BM mainly by reducing fat mass. AA metabolism shows subtle changes with dapagliflozin treatment. ","subitem_description_type":"Abstract"}]},"item_4_description_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Journal Article","subitem_description_type":"Other"}]},"item_4_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier B.V."}]},"item_4_relation_10":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"35181350","subitem_relation_type_select":"PMID"}}]},"item_4_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"10.1016/j.diabres.2022.109781"}],"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1016/j.diabres.2022.109781","subitem_relation_type_select":"DOI"}}]},"item_4_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":" © 2022 Elsevier B.V. All rights reserved. "}]},"item_4_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1872-8227","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"HORIBE, Kayo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"MORINO, Katsutaro"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"MIYAZAWA, Itsuko"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Tanaka-Mizuno, Sachiko"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"KONDO, Keiko"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"SATO, Daisuke"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"OHASHI, Natsuko"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"IDA, Shogo"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"YANAGIMACHI, Tsuyoshi"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"YOSHIMURA, Masahiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"ITOH, Ryuta"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"MURATA, Kiyoshi"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"MIURA, Katsuyuki"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"ARIMA, Hisatomi"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"FUJITA, Yukihiro"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"UGI, Satoshi"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"MAEGAWA, Hiroshi"}],"nameIdentifiers":[{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-02-15"}],"displaytype":"detail","filename":"j.diabres.2022.109781.pdf","filesize":[{"value":"1.3 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"j.diabres.2022.109781","url":"https://shiga-med.repo.nii.ac.jp/record/4188/files/j.diabres.2022.109781.pdf"},"version_id":"059126d6-4dd6-45a5-b9cb-6050766fa2c1"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Sodium glucose cotransport","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Fat mass","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Muscle mass","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Non-alcoholic fatty liver disease","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Nuclear magnetic resonance spectroscopy","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Amino acid","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Metabolic changes induced by dapagliflozin, an SGLT2 inhibitor, in Japanese patients with type 2 diabetes treated by oral anti-diabetic agents: A randomized, clinical trial.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Metabolic changes induced by dapagliflozin, an SGLT2 inhibitor, in Japanese patients with type 2 diabetes treated by oral anti-diabetic agents: A randomized, clinical trial."}]},"item_type_id":"4","owner":"11","path":["71","203","221","262","411","413"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-04-12"},"publish_date":"2022-04-12","publish_status":"0","recid":"4188","relation_version_is_last":true,"title":["Metabolic changes induced by dapagliflozin, an SGLT2 inhibitor, in Japanese patients with type 2 diabetes treated by oral anti-diabetic agents: A randomized, clinical trial."],"weko_creator_id":"11","weko_shared_id":-1},"updated":"2023-06-19T11:16:50.706983+00:00"}