{"created":"2023-06-19T10:43:46.767358+00:00","id":4091,"links":{},"metadata":{"_buckets":{"deposit":"885229ce-a744-47a5-9134-01f087ccd921"},"_deposit":{"created_by":11,"id":"4091","owners":[11],"pid":{"revision_id":0,"type":"depid","value":"4091"},"status":"published"},"_oai":{"id":"oai:shiga-med.repo.nii.ac.jp:00004091","sets":["30:253:254","30:96:97"]},"author_link":["3686","8806","1988","3687","742"],"item_4_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-12-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicPageEnd":"838","bibliographicPageStart":"826","bibliographicVolumeNumber":"78","bibliographic_titles":[{},{"bibliographic_title":"Journal of cardiovascular pharmacology","bibliographic_titleLang":"en"}]}]},"item_4_creator_3":{"attribute_name":"著者別名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"石原, 真理子"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"小嶋, 亜希子"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"林, 維光"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"北川, 裕利"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"松浦, 博"}],"nameIdentifiers":[{},{},{}]}]},"item_4_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"pdf","subitem_description_type":"Other"}]},"item_4_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Dexmedetomidine (DEX), an α2-adrenoreceptor (α2-AR) and imidazoline receptor agonist, is most often used for the sedation of patients in the intensive care unit. Its administration is associated with an increased incidence of bradycardia; however, the precise mechanism of DEX-induced bradycardia has yet to be fully elucidated. This study was undertaken to examine whether DEX modifies pacemaker activity and the underlying ionic channel function through α2-AR and imidazoline receptors. The whole-cell patch-clamp techniques were used to record action potentials and related ionic currents of sinoatrial node cells in guinea pigs. DEX (≥10 nM) reduced sinoatrial node automaticity and the diastolic depolarization rate. DEX reduced the amplitude of hyperpolarization-activated cation current (If or Ih) the pacemaker current, even within the physiological pacemaker potential range. DEX slowed the If current activation kinetics and caused a significant shift in the voltage dependence of channel activation to negative potentials. In addition, efaroxan, an α2-AR and imidazoline I1 receptor antagonist, attenuated the inhibitory effects of DEX on sinoatrial node automaticity and If current activity, whereas yohimbine, an α2-AR-selective antagonist, did not. DEX did not affect the current activities of other channels, including rapidly and slowly activating delayed rectifier K+ currents (IKr and IKs), L-type Ca2+ current (ICa,L), Na+/Ca2+ exchange current (INCX), and muscarinic K+ current (IK,ACh). Our results indicate that DEX, at clinically relevant concentrations, induced a negative chronotropic effect on the sinoatrial node function through the downregulation of If current through an imidazoline I1 receptor other than the α2-AR in the clinical setting.","subitem_description_type":"Abstract"}]},"item_4_description_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Journal Article","subitem_description_type":"Other"}]},"item_4_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Lippincott Williams & Wilkins"}]},"item_4_relation_10":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"34448469","subitem_relation_type_select":"PMID"}}]},"item_4_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"10.1097/FJC.0000000000001133"}],"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1097/fjc.0000000000001133","subitem_relation_type_select":"DOI"}}]},"item_4_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2021 Wolters Kluwer Health, Inc. All rights reserved. "}]},"item_4_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1533-4023","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"ISHIHARA, Mariko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"KOJIMA, Akiko"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"DING, Wei-guang"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"KITAGAWA, Hirotoshi"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"MATSUURA, Hiroshi"}],"nameIdentifiers":[{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-12-01"}],"displaytype":"detail","filename":"FJC.0000000000001133.pdf","filesize":[{"value":"2.2 MB"}],"format":"application/pdf","license_note":" © 2021 Wolters Kluwer Health, Inc. All rights reserved.","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"FJC.0000000000001133","url":"https://shiga-med.repo.nii.ac.jp/record/4091/files/FJC.0000000000001133.pdf"},"version_id":"bbb0fb56-c19f-44db-a984-483d133eb5ef"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"dexmedetomidine","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"α2-adrenoceptor","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"imidazoline receptor","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"sinoatrial node cells","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"hyperpolarization-activated cation current","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"automaticity","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Dexmedetomidine Exerts a Negative Chronotropic Action on Sinoatrial Node Cells Through the Activation of Imidazoline Receptors.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Dexmedetomidine Exerts a Negative Chronotropic Action on Sinoatrial Node Cells Through the Activation of Imidazoline Receptors."}]},"item_type_id":"4","owner":"11","path":["97","254"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-01-20"},"publish_date":"2022-01-20","publish_status":"0","recid":"4091","relation_version_is_last":true,"title":["Dexmedetomidine Exerts a Negative Chronotropic Action on Sinoatrial Node Cells Through the Activation of Imidazoline Receptors."],"weko_creator_id":"11","weko_shared_id":-1},"updated":"2023-06-19T11:19:14.219163+00:00"}