{"created":"2023-06-19T10:43:45.093747+00:00","id":4052,"links":{},"metadata":{"_buckets":{"deposit":"528c108d-92e4-4f73-b71e-d915247b4ab8"},"_deposit":{"created_by":11,"id":"4052","owners":[11],"pid":{"revision_id":0,"type":"depid","value":"4052"},"status":"published"},"_oai":{"id":"oai:shiga-med.repo.nii.ac.jp:00004052","sets":["30:293:294","77:387:388","77:78:79"]},"author_link":["570","8451","321","7646","675","8770","8769","7645","5038","677"],"item_4_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-11-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"316","bibliographicPageStart":"311","bibliographicVolumeNumber":"69","bibliographic_titles":[{},{"bibliographic_title":"Journal of Clinical Biochemistry and Nutrition","bibliographic_titleLang":"en"}]}]},"item_4_creator_3":{"attribute_name":"著者別名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"福井, 里佳"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"寺田, 智祐"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"平, 大樹"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"國津, 侑貴"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"磯野, 哲一郎"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"田淵, 陽平"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"生野, 芳博"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"伊藤, 英樹"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"田中, 俊宏"}],"nameIdentifiers":[{},{},{}]}]},"item_4_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"pdf","subitem_description_type":"Other"}]},"item_4_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"In clinical practice, edoxaban is sometimes prescribed for off-label use based on the hypothesis that it is as safe and effective as warfarin. However, there is limited safety information on off-label use due to lack of clinical trial. We aimed to analyze the tolerability of off-label use of edoxaban and to identify patient characteristics associated with major bleeding as adverse effects. Patients under edoxaban treatment between January 2017 and December 2017 were enrolled in this retrospective cohort study. The incidence of major bleeding with off-label use compared with on-label use was analyzed using by log-rank test. Univariate and multivariate regression analysis were undertaken to detect independent variables with significant odds ratio that associated with major bleeding. After the exclusion criteria were applied, the patients were divided into two groups: off-label group (n = 30) and on-label group (n = 161). Incidence of major bleeding was found to be higher in the off-label group (13.3%) than in the on-label group (3.7%) (p<0.05). Multivariate adjustment showed that the off-label use or portal vein thrombosis and patients with history of major bleeding has significantly higher incidence of major bleeding. We demonstrated that off-label use of edoxaban may be a significant risk factor for major bleeding.","subitem_description_type":"Abstract"}]},"item_4_description_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Journal Article","subitem_description_type":"Other"}]},"item_4_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"一般社団法人　日本酸化ストレス学会"}]},"item_4_publisher_34":{"attribute_name":"別言語の出版者","attribute_value_mlt":[{"subitem_publisher":"SOCIETY FOR FREE RADICAL RESEARCH JAPAN"}]},"item_4_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"10.3164/jcbn.21-9"}],"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.3164/jcbn.21-9","subitem_relation_type_select":"DOI"}}]},"item_4_relation_28":{"attribute_name":"論文ID（NAID）","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"130008110266","subitem_relation_type_select":"NAID"}}]},"item_4_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2021 JCBN"}]},"item_4_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0912-0009","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"FUKUI, Rika"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"HIRA, Daiki"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"KUNITSU, Yuki"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"ISONO, Tetsuichiro"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"TABUCHI, Yohei"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"IKUNO, Yoshihiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"UESHIMA, Satoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"ITOH, Hideki"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"TANAKA, Toshihiro"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"TERADA, Tomohiro"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-11-30"}],"displaytype":"detail","filename":"jcbn.21-9.pdf","filesize":[{"value":"275.6 kB"}],"format":"application/pdf","license_note":"This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License.\nhttps://creativecommons.org/licenses/by-nc-nd/4.0/","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"jcbn.21-9","url":"https://shiga-med.repo.nii.ac.jp/record/4052/files/jcbn.21-9.pdf"},"version_id":"72189942-01e4-4008-9710-d2ce9206a68f"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"direct oral anticoagulants","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"edoxaban","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"anticoagulants","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"off-label","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"bleeding","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"High incidence of major bleeding with off-label use of edoxaban","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"High incidence of major bleeding with off-label use of edoxaban"}]},"item_type_id":"4","owner":"11","path":["79","294","388"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-11-30"},"publish_date":"2021-11-30","publish_status":"0","recid":"4052","relation_version_is_last":true,"title":["High incidence of major bleeding with off-label use of edoxaban"],"weko_creator_id":"11","weko_shared_id":-1},"updated":"2023-06-19T11:20:25.841960+00:00"}