@article{oai:shiga-med.repo.nii.ac.jp:00004030,
 author = {杉本, 光繁 and 村田, 雅樹 and SUGIMOTO, Mitsushige and HATTA, Waku and TSUJI, Yosuke and YOSHIO, Toshiyuki and YABUUCHI, Yohei and HOTEYA, Shu and DOYAMA, Hisashi and NAGAMI, Yasuaki and HIKICHI, Takuto and KOBAYASHI, Masakuni and MORITA, Yoshinori and SUMIYOSHI, Tetsuya and IGUCHI, Mikitaka and TOMIDA, Hideomi and INOUE, Takuya and MIKAMI, Tatsuya and HASATANI, Kenkei and NISHIKAWA, Jun and MATSUMURA, Tomoaki and NEBIKI, Hiroko and NAKAMATSU, Dai and OHNITA, Ken and SUZUKI, Haruhisa and UEYAMA, Hiroya and HAYASHI, Yoshito and MURATA, Masaki and YAMAGUCHI, Shinjiro and MICHIDA, Tomoki and YADA, Tomoyuki and ASAHINA, Yoshiro and NARASAKA, Toshiaki and KURIBAYASHI, Shiko and KIYOTOKI, Shu and MABE, Katsuhiro and FUJISHIRO, Mitsuhiro and MASAMUNE, Atsushi and KAWAI, Takashi},
 issue = {9},
 journal = {Clinical and translational gastroenterology},
 month = {},
 note = {pdf, Introduction:
As the aging of people in a society advances, the number of elderly patients older than 80 years in Japan with gastric cancer continues to increase. Although delayed ulcer bleeding is a major adverse event after endoscopic submucosal dissection (ESD), little is known about characteristic risk factors for bleeding in elderly patients undergoing ESD. This study aimed to evaluate risk factors for delayed bleeding after ESD for gastric cancer in elderly patients older than 80 years., Methods:
We retrospectively evaluated the incidence of delayed bleeding after ESD in 10,320 patients with early-stage gastric cancer resected by ESD between November 2013 and January 2016 at 33 Japanese institutions and investigated risk factors for delayed bleeding in elderly patients older than 80 years., Results:
The incidence of delayed bleeding in elderly patients older than 80 years was 5.7% (95% confidence interval [CI]: 4.6%-6.9%, 95/1,675), which was significantly higher than that in nonelderly (older than 20 years and younger than 80 years) patients (4.5%, 4.1%-5.0%, 393/8,645). Predictive factors for ESD-associated bleeding differed between nonelderly and elderly patients. On multivariate analysis of predictive factors at the time of treatment, risk factors in elderly patients were hemodialysis (odds ratio: 4.591, 95% CI: 2.056-10.248, P < 0.001) and warfarin use (odds ratio: 4.783, 95% CI: 1.689-13.540, P = 0.003)., Discussion:
This multicenter study found that the incidence of delayed bleeding after ESD in Japanese patients older than 80 years was high, especially in patients receiving hemodialysis and taking warfarin. Management of ESD to prevent delayed bleeding requires particular care in patients older than 80 years., Journal Article},
 title = {Risk Factors for Bleeding After Endoscopic Submucosal Dissection for Gastric Cancer in Elderly Patients Older Than 80 Years in Japan.},
 volume = {12},
 year = {2021}
}