@article{oai:shiga-med.repo.nii.ac.jp:00004014, author = {中村, 保幸 and 松井, 健志 and 高嶋, 直敬 and 門田, 文 and 三浦, 克之 and 喜多, 義邦 and NAKAMURA, Yasuyuki and NARITA, Akira and SUTOH, Yoichi and IMAEDA, Nahomi and GOTO, Chiho and MATSUI, Kenji and TAKASHIMA, Naoyuki and KADOTA, Aya and MIURA, Katsuyuki and NAKATOCHI, Masahiro and TAMURA, Takashi and HISHIDA, Asahi and NAKASHIMA, Ryoko and IKEZAKI, Hiroaki and HARA, Megumi and NISHIDA, Yuichiro and TAKEZAKI, Toshiro and IBUSUKI, Rie and OZE, Isao and ITO, Hidemi and KURIYAMA, Nagato and OZAKI, Etsuko and MIKAMI, Haruo and KUSAKABE, Miho and NAKAGAWA-SENDA, Hiroko and SUZUKI, Sadao and KATSUURA-KAMANO, Sakurako and ARISAWA, Kokichi and KURIKI, Kiyonori and Momozawa, Yukihide and Kubo, Michiaki and TAKEUCHI, Kenji and KITA, Yoshikuni and WAKAI, Kenji}, journal = {Journal of nutritional science}, month = {Nov}, note = {pdf, Recent genome-wide association studies (GWAS) on the dietary habits of the Japanese population have shown that an effect rs671 allele was inversely associated with fish consumption, whereas it was directly associated with coffee consumption. Although meat is a major source of protein and fat in the diet, whether genetic factors that influence meat-eating habits in healthy populations are unknown. This study aimed to conduct a GWAS to find genetic variations that affect meat consumption in a Japanese population. We analysed GWAS data using 14 076 participants from the Japan Multi-Institutional Collaborative Cohort (J-MICC) study. We used a semi-quantitative food frequency questionnaire to estimate food intake that was validated previously. Association of the imputed variants with total meat consumption per 1000 kcal energy was performed by linear regression analysis with adjustments for age, sex, and principal component analysis components 1-10. We found that no genetic variant, including rs671, was associated with meat consumption. The previously reported single nucleotide polymorphisms that were associated with meat consumption in samples of European ancestry could not be replicated in our J-MICC data. In conclusion, significant genetic factors that affect meat consumption were not observed in a Japanese population., Journal Article}, title = {A genome-wide association study on meat consumption in a Japanese population : the Japan Multi-Institutional Collaborative Cohort study.}, volume = {10}, year = {2021} }