{"created":"2023-06-19T10:43:42.749512+00:00","id":3995,"links":{},"metadata":{"_buckets":{"deposit":"55421b3a-86bd-49d7-92e9-fbaed1939eb9"},"_deposit":{"created_by":11,"id":"3995","owners":[11],"pid":{"revision_id":0,"type":"depid","value":"3995"},"status":"published"},"_oai":{"id":"oai:shiga-med.repo.nii.ac.jp:00003995","sets":["30:229:230","77:325:326"]},"author_link":["7995","8477","7695","6088","7996","8195","173","7642"],"item_4_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-09-22","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"9","bibliographicVolumeNumber":"16","bibliographic_titles":[{},{"bibliographic_title":"PLoS ONE","bibliographic_titleLang":"en"}]}]},"item_4_creator_3":{"attribute_name":"著者別名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"川口, 庸"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"花岡, 淳"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"大塩, 恭彦"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"岡本, 圭伍"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"賀来, 良輔"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"林, 一喜"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"白鳥, 琢也"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"赤澤, 彰"}],"nameIdentifiers":[{}]}]},"item_4_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"pdf","subitem_description_type":"Other"}]},"item_4_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background:\nSarcopenia is among the most prevalent and serious cancer-related symptom, and is strongly correlated with a poor prognosis. Moreover, it reportedly predicts poor prognosis after surgery in patients with lung cancer. However, it is unclear whether sarcopenia directly affects post-operative recurrence. The purpose of this study was to evaluate whether sarcopenia can be a risk indicator for post-operative recurrence, and whether it suppresses anti-tumor immunity, in a cohort of patients with resected non-small cell lung cancer. ","subitem_description_type":"Abstract"},{"subitem_description":"Methods:\nThis study retrospectively reviewed the data of 256 consecutive patients who underwent curative lobectomy and lymph node dissection for non-small cell lung cancer at our institution. The psoas muscle mass index was calculated as the total psoas muscle area at the third lumbar vertebral level/height2 (cm2/m2). Sarcopenia was defined by a psoas muscle mass index of under 5.03 cm2/m2 and 3.17 cm2/m2 in male and female patients, respectively. Post-operative prognosis and cumulative incidence of recurrence rates were calculated. ","subitem_description_type":"Abstract"},{"subitem_description":"Results:\nThe 5-year overall survival and disease-free survival rates post-surgery were 59.5% and 38.6%, respectively, in patients with sarcopenia versus 81.1% and 72.1%, respectively, in patients without sarcopenia (p < 0.001). The 5-year cumulative incidence of recurrence rate in patients with sarcopenia was significantly higher than those without sarcopenia (49.9% versus 22.4%, respectively) in every pathological stage. Pathological stages II and III (hazard ratio, 3.36; p = 0.004), histological type (hazard ratio, 2.31; p = 0.025), and sarcopenia (hazard ratio, 2.52; p = 0.001) were independent risk factors for post-operative recurrence according to multivariate analysis. ","subitem_description_type":"Abstract"},{"subitem_description":"Conclusion:\nSarcopenia is a risk indicator for post-operative recurrence in patients with non-small cell lung cancer. ","subitem_description_type":"Abstract"}]},"item_4_description_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Journal Article","subitem_description_type":"Other"}]},"item_4_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Public Library of Science"}]},"item_4_relation_10":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"34551011","subitem_relation_type_select":"PMID"}}]},"item_4_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"10.1371/journal.pone.0257594"}],"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1371/journal.pone.0257594","subitem_relation_type_select":"DOI"}}]},"item_4_relation_13":{"attribute_name":"PMCID","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"PMC8457491"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.ncbi.nlm.nih.gov/pmc/articles/pmc8457491/","subitem_relation_type_select":"URI"}}]},"item_4_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2021 Kawaguchi et al."}]},"item_4_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1932-6203","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"KAWAGUCHI, Yo"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"HANAOKA, Jun"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"OHSHIO, Yasuhiko"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"OKAMOTO, Keigo"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"KAKU, Ryosuke"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"HAYASHI, Kazuki"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"SHIRATORI, Takuya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"AKAZAWA, Akira"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-10-05"}],"displaytype":"detail","filename":"journal.pone.0257594.pdf","filesize":[{"value":"782.8 kB"}],"format":"application/pdf","license_note":"This is an open access article distributed under the terms of the Creative\nCommons Attribution License, which permits unrestricted use, \ndistribution, and reproduction in any medium, provided the original author\nand source are credited.","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"journal.pone.0257594","url":"https://shiga-med.repo.nii.ac.jp/record/3995/files/journal.pone.0257594.pdf"},"version_id":"b0fc77ec-1960-4c8f-98c4-4f5816db3ddb"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Sarcopenia increases the risk of post-operative recurrence in patients with non-small cell lung cancer.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Sarcopenia increases the risk of post-operative recurrence in patients with non-small cell lung cancer."}]},"item_type_id":"4","owner":"11","path":["230","326"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-10-05"},"publish_date":"2021-10-05","publish_status":"0","recid":"3995","relation_version_is_last":true,"title":["Sarcopenia increases the risk of post-operative recurrence in patients with non-small cell lung cancer."],"weko_creator_id":"11","weko_shared_id":-1},"updated":"2023-06-19T11:21:37.039452+00:00"}