@article{oai:shiga-med.repo.nii.ac.jp:00003995,
 author = {川口, 庸 and 花岡, 淳 and 大塩, 恭彦 and 岡本, 圭伍 and 賀来, 良輔 and 林, 一喜 and 白鳥, 琢也 and 赤澤, 彰 and KAWAGUCHI, Yo and HANAOKA, Jun and OHSHIO, Yasuhiko and OKAMOTO, Keigo and KAKU, Ryosuke and HAYASHI, Kazuki and SHIRATORI, Takuya and AKAZAWA, Akira},
 issue = {9},
 journal = {PLoS ONE},
 month = {Sep},
 note = {pdf, Background:
Sarcopenia is among the most prevalent and serious cancer-related symptom, and is strongly correlated with a poor prognosis. Moreover, it reportedly predicts poor prognosis after surgery in patients with lung cancer. However, it is unclear whether sarcopenia directly affects post-operative recurrence. The purpose of this study was to evaluate whether sarcopenia can be a risk indicator for post-operative recurrence, and whether it suppresses anti-tumor immunity, in a cohort of patients with resected non-small cell lung cancer., Methods:
This study retrospectively reviewed the data of 256 consecutive patients who underwent curative lobectomy and lymph node dissection for non-small cell lung cancer at our institution. The psoas muscle mass index was calculated as the total psoas muscle area at the third lumbar vertebral level/height2 (cm2/m2). Sarcopenia was defined by a psoas muscle mass index of under 5.03 cm2/m2 and 3.17 cm2/m2 in male and female patients, respectively. Post-operative prognosis and cumulative incidence of recurrence rates were calculated., Results:
The 5-year overall survival and disease-free survival rates post-surgery were 59.5% and 38.6%, respectively, in patients with sarcopenia versus 81.1% and 72.1%, respectively, in patients without sarcopenia (p < 0.001). The 5-year cumulative incidence of recurrence rate in patients with sarcopenia was significantly higher than those without sarcopenia (49.9% versus 22.4%, respectively) in every pathological stage. Pathological stages II and III (hazard ratio, 3.36; p = 0.004), histological type (hazard ratio, 2.31; p = 0.025), and sarcopenia (hazard ratio, 2.52; p = 0.001) were independent risk factors for post-operative recurrence according to multivariate analysis., Conclusion:
Sarcopenia is a risk indicator for post-operative recurrence in patients with non-small cell lung cancer., Journal Article},
 title = {Sarcopenia increases the risk of post-operative recurrence in patients with non-small cell lung cancer.},
 volume = {16},
 year = {2021}
}