{"created":"2023-06-19T10:43:42.146834+00:00","id":3981,"links":{},"metadata":{"_buckets":{"deposit":"eae1bbf9-06be-46b2-8b9f-bfcd901d664a"},"_deposit":{"created_by":11,"id":"3981","owners":[11],"pid":{"revision_id":0,"type":"depid","value":"3981"},"status":"published"},"_oai":{"id":"oai:shiga-med.repo.nii.ac.jp:00003981","sets":["30:200:201"]},"author_link":["7412","7413","8619","300","7411","8618","7409","8621","7408","7410","6474","8620","7414"],"item_4_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-09-09","bibliographicIssueDateType":"Issued"},"bibliographicVolumeNumber":"4","bibliographic_titles":[{},{"bibliographic_title":"Scientific Reports","bibliographic_titleLang":"en"}]}]},"item_4_creator_3":{"attribute_name":"著者別名","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"14202","affiliationNameIdentifierScheme":"kakenhi"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"KADOTANI, Hiroshi","creatorNameLang":"en"},{"creatorName":"角谷, 寛","creatorNameLang":"ja"},{"creatorName":"カドタニ, ヒロシ","creatorNameLang":"ja-Kana"}],"familyNames":[{"familyName":"KADOTANI","familyNameLang":"en"},{"familyName":"角谷","familyNameLang":"ja"},{"familyName":"カドタニ","familyNameLang":"ja-Kana"}],"givenNames":[{"givenName":"Hiroshi","givenNameLang":"en"},{"givenName":"寛","givenNameLang":"ja"},{"givenName":"ヒロシ","givenNameLang":"ja-Kana"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"大川, 匡子"}],"nameIdentifiers":[{},{},{}]}]},"item_4_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"pdf","subitem_description_type":"Other"}]},"item_4_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"A system of self-sustained biological clocks controls the 24-h rhythms of behavioral and physiological processes such as the sleep-wake cycle. The circadian clock system is regulated by transcriptional and translational negative feedback loops of multiple clock genes. Polymorphisms in circadian clock genes have been associated with morningness-eveningness (diurnal) preference, familial advanced sleep phase type (ASPT), and delayed sleep phase type (DSPT). We genotyped single-nucleotide polymorphisms in circadian clock genes in 182 DSPT individuals, 67 free-running type (FRT) individuals, and 925 controls. The clock gene polymorphisms were tested for associations with diurnal preference and circadian rhythm sleep disorder (CRSD) phenotypes. The PER3 polymorphism (rs228697) was significantly associated with diurnal preference and the FRT phenotype. The minor allele of rs228697 was more prevalent in evening types than in morning types (sex-adjusted odds ratio (OR), 2.483, Bonferroni-corrected P = 0.012) and in FRT individuals compared with the controls (age- and sex-adjusted OR, 2.021, permutated P = 0.017). Our findings support the notion that PER3 polymorphisms could be a potential genetic marker for an individual's circadian and sleep phenotypes. ","subitem_description_type":"Abstract"}]},"item_4_description_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Journal Article","subitem_description_type":"Other"}]},"item_4_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer Nature"}]},"item_4_relation_10":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"25201053","subitem_relation_type_select":"PMID"}}]},"item_4_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"10.1038/srep06309"}],"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1038/srep06309","subitem_relation_type_select":"DOI"}}]},"item_4_relation_13":{"attribute_name":"PMCID","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"PMC4158573"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.ncbi.nlm.nih.gov/pmc/articles/pmc4158573/","subitem_relation_type_select":"URI"}}]},"item_4_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2014, The Author(s) "}]},"item_4_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2045-2322","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"HIDA, Akiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"KITAMURA, Shingo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"KATAYOSE, Yasuko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"KATO, Mie"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"ONO, Hiroko"}],"nameIdentifiers":[{}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"14202","affiliationNameIdentifierScheme":"kakenhi"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"KADOTANI, Hiroshi","creatorNameLang":"en"},{"creatorName":"角谷, 寛","creatorNameLang":"ja"},{"creatorName":"カドタニ, ヒロシ","creatorNameLang":"ja-Kana"}],"familyNames":[{"familyName":"KADOTANI","familyNameLang":"en"},{"familyName":"角谷","familyNameLang":"ja"},{"familyName":"カドタニ","familyNameLang":"ja-Kana"}],"givenNames":[{"givenName":"Hiroshi","givenNameLang":"en"},{"givenName":"寛","givenNameLang":"ja"},{"givenName":"ヒロシ","givenNameLang":"ja-Kana"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"UCHIYAMA, Makoto"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"EBISAWA, Takashi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"INOUE, Yuichi"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"KAMEI, Yuichi"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"OKAWA, Masako"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"TAKAHASHI, Kiyohisa"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"MISHIMA, Kazuo"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-09-22"}],"displaytype":"detail","filename":"srep06309.pdf","filesize":[{"value":"255.3 kB"}],"format":"application/pdf","license_note":"This work is licensed under a Creative Commons Attribution-\nNonCommercial-NoDerivs 4.0 International License. The images or \nother third party material in this article are included in the article's \nCreative Commons license, unless indicated otherwise in the credit line;\nif the material is not included under the Creative Commons license, \nusers will need to obtain permission from the license holder in order to \nreproduce the material. To view a copy of this license, visit \nhttp://creativecommons.org/licenses/by-nc-nd/4.0/","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"srep06309","url":"https://shiga-med.repo.nii.ac.jp/record/3981/files/srep06309.pdf"},"version_id":"8bcf1d6b-ddac-4fa7-b9c0-8e1aa3439d75"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Circadian rhythms and sleep","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Genetic association study","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Screening of clock gene polymorphisms demonstrates association of a PER3 polymorphism with morningness-eveningness preference and circadian rhythm sleep disorder.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Screening of clock gene polymorphisms demonstrates association of a PER3 polymorphism with morningness-eveningness preference and circadian rhythm sleep disorder."}]},"item_type_id":"4","owner":"11","path":["201"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-09-22"},"publish_date":"2021-09-22","publish_status":"0","recid":"3981","relation_version_is_last":true,"title":["Screening of clock gene polymorphisms demonstrates association of a PER3 polymorphism with morningness-eveningness preference and circadian rhythm sleep disorder."],"weko_creator_id":"11","weko_shared_id":-1},"updated":"2023-07-24T11:31:39.242159+00:00"}