{"created":"2023-06-19T10:43:42.104147+00:00","id":3980,"links":{},"metadata":{"_buckets":{"deposit":"e1d394f1-8357-4a8c-845e-4cf2469ec48b"},"_deposit":{"created_by":11,"id":"3980","owners":[11],"pid":{"revision_id":0,"type":"depid","value":"3980"},"status":"published"},"_oai":{"id":"oai:shiga-med.repo.nii.ac.jp:00003980","sets":["19:287:288","30:261:262","77:257:258"]},"author_link":["2433","8617","499","137","7960"],"item_4_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-09-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"271","bibliographicPageStart":"264","bibliographicVolumeNumber":"20","bibliographic_titles":[{},{"bibliographic_title":"Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine","bibliographic_titleLang":"en"}]}]},"item_4_creator_3":{"attribute_name":"著者別名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"高木, 海"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"森川, 茂廣"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"村田, 喜代史"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"井藤, 隆太"}],"nameIdentifiers":[{},{}]}]},"item_4_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"pdf","subitem_description_type":"Other"}]},"item_4_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Purpose: \n(1) To evaluate the enhancement patterns of an ultrasmall superparamagnetic iron oxide contrast agent (USPIO-CA) compared with those of a gadolinium-based contrast agent (Gd-BCA). (2) To compare the histologic distribution of USPIO-related iron particles (USPIO-IPs) with the USPIO-enhancement area in the early vascular and in the cellular imaging phase (E- and L-phase, respectively) after intravenous CA administration. ","subitem_description_type":"Abstract"},{"subitem_description":"Methods:\nWe performed USPIO-enhanced MRI of N-ethyl-N-nitrosourea (ENU)-induced endogenous rat glioma, including spin-echo (SE) T1-weighted images (T1WIs) and gradient-recalled-echo (GRE) T2-weighted images (T2WIs), before and at 3-6 h after USPIO-CA administration for E-phase images. For L-phase images, MRI was performed at 16-19 and 62-69 h after administration. Two observers determined the USPIO-enhancement area on E-phase images and Gd-enhancement areas. We compared the USPIO-enhancement size (USPIO-ES) and Gd-ES on SE T1WIs, and the hypo-intense USPIO-ES on GRE T2WIs and Gd-ES using the Wilcoxon signed-rank test. In addition, two raters visually evaluated the correspondence between the histologic distribution of USPIO-IPs and the USPIO-enhancement area on corresponding GRE T2WIs at each phase using a 3-rating scale. ","subitem_description_type":"Abstract"},{"subitem_description":"Results:\nSignificantly smaller hyper-intense, hypo-intense and combined hyper-/hypo-intense areas were observed on USPIO-enhanced SE T1WIs compared with Gd-enhanced images (all P < 0.001). The hypo-intense USPIO-ES on GRE T2WIs was significantly smaller than the Gd-ES (P = 0.001). The distribution of USPIO-IPs on histopathological specimen and USPIO-enhancement on GRE T2WIs exhibited poor agreement in 5 of 9 tumors with enhancement from rats sacrificed early. The distribution of microglia containing USPIO-IPs corresponded with the pattern of USPIO-enhancement in the 2 tumors with late enhancement. ","subitem_description_type":"Abstract"},{"subitem_description":"Conclusion:\nThe enhancement pattern and size of USPIO-CA in a rat glioma model were statistically different from those of Gd-BCA. Our histological data suggests that USPIO-enhanced MRI offers vascular bed imaging in E-phase and might depict the intra-tumoral distribution of immune effector cells in L-phase. ","subitem_description_type":"Abstract"}]},"item_4_description_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Journal Article","subitem_description_type":"Other"}]},"item_4_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Japanese Society for Magnetic Resonance in Medicine"}]},"item_4_publisher_34":{"attribute_name":"別言語の出版者","attribute_value_mlt":[{"subitem_publisher":"日本磁気共鳴医学会"}]},"item_4_relation_10":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"32830172","subitem_relation_type_select":"PMID"}}]},"item_4_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"10.2463/mrms.mp.2019-0134"}],"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.2463/mrms.mp.2019-0134","subitem_relation_type_select":"DOI"}}]},"item_4_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2020 by Japanese Society for Magnetic Resonance in Medicine "}]},"item_4_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1880-2206","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"YAMAMOTO, Atsuko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"TAKAKI, Kai"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"MORIKAWA, Shigehiro"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"MURATA, Kiyoshi"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"ITOH, Ryuta"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-09-21"}],"displaytype":"detail","filename":"mrms.mp.2019-0134.pdf","filesize":[{"value":"15.5 MB"}],"format":"application/pdf","license_note":"This article is licensed under a Creative Commons [Attribution-NonCommercial-NoDerivatives 4.0 International] license.\nhttps://creativecommons.org/licenses/by-nc-nd/4.0/","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"mrms.mp.2019-0134","url":"https://shiga-med.repo.nii.ac.jp/record/3980/files/mrms.mp.2019-0134.pdf"},"version_id":"8dd70d57-f7ff-4d1a-b8d1-230aa427c90c"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"ultrasmall superparamagnetic iron oxide contrast agent","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"rat glioma","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"histological correlation","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Histologic Distribution and Characteristics on MR Imaging of Ultrasmall Superparamagnetic Iron Oxide in Ethyl-nitrosourea-induced Endogenous Rat Glioma.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Histologic Distribution and Characteristics on MR Imaging of Ultrasmall Superparamagnetic Iron Oxide in Ethyl-nitrosourea-induced Endogenous Rat Glioma."}]},"item_type_id":"4","owner":"11","path":["258","262","288"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-09-21"},"publish_date":"2021-09-21","publish_status":"0","recid":"3980","relation_version_is_last":true,"title":["Histologic Distribution and Characteristics on MR Imaging of Ultrasmall Superparamagnetic Iron Oxide in Ethyl-nitrosourea-induced Endogenous Rat Glioma."],"weko_creator_id":"11","weko_shared_id":-1},"updated":"2023-06-19T11:21:58.230423+00:00"}