{"created":"2023-06-19T10:43:41.972412+00:00","id":3977,"links":{},"metadata":{"_buckets":{"deposit":"ae06dd62-7be6-4862-be7b-b71ae60182de"},"_deposit":{"created_by":11,"id":"3977","owners":[11],"pid":{"revision_id":0,"type":"depid","value":"3977"},"status":"published"},"_oai":{"id":"oai:shiga-med.repo.nii.ac.jp:00003977","sets":["30:198:199","77:242:243"]},"author_link":["552","7986","707","3015","2501","643","8493","636","1956"],"item_4_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-09-09","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicVolumeNumber":"11","bibliographic_titles":[{},{"bibliographic_title":"Scientific Reports","bibliographic_titleLang":"en"}]}]},"item_4_creator_3":{"attribute_name":"著者別名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"中村, 竜太郎"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"栗原, 美香"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"小川, 暢弘"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"北村, 彰浩"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"山川, 勇"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"馬場, 重樹"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"真田, 充"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"佐々木, 雅也"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"漆谷, 真"}],"nameIdentifiers":[{},{},{}]}]},"item_4_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"pdf","subitem_description_type":"Other"}]},"item_4_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"To examine whether hypermetabolism could predict the prognosis of early amyotrophic lateral sclerosis (ALS) patients with differing nutritional profiles. This single-center, retrospective study examined the prognosis of ALS patients with hypermetabolism in relation to their nutritional status at hospitalization. The metabolic state was estimated by the ratio of measured resting energy expenditure (mREE) to lean soft tissue mass (LSTM) (mREE/LSTM), wherein patients with ratios ≥ 38 were defined as hypermetabolic. Malnutrition was defined as %ideal body weight < 0.9. Forty-eight patients were enrolled in this study. The hypermetabolic group had shorter survival in the normal-weight group but more prolonged survival in the malnutrition group. Multiplication of nutritional and metabolic factors, such as [(body mass index (BMI) - 19.8) × (mREE/LSTM - 38)], designated as BMI-muscle metabolism index (BMM index), successfully predicted the prognosis in the group with a high BMM index (≥ 1), which showed shorter survival and a faster rate of weight loss and functional decline. Multivariate analysis using the Cox model showed high BMM index was an independent poor prognostic factor (hazard ratio: 4.05; p = 0.025). Prognostic prediction by hypermetabolism varies depending on the nutritional status in ALS, and the BMM index is a consistent prognostic factor. ","subitem_description_type":"Abstract"}]},"item_4_description_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Journal Article","subitem_description_type":"Other"}]},"item_4_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer Nature"}]},"item_4_relation_10":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"34504168","subitem_relation_type_select":"PMID"}}]},"item_4_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"10.1038/s41598-021-97196-5"}],"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1038/s41598-021-97196-5","subitem_relation_type_select":"DOI"}}]},"item_4_relation_13":{"attribute_name":"PMCID","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"PMC8429558"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.ncbi.nlm.nih.gov/pmc/articles/pmc8429558/","subitem_relation_type_select":"URI"}}]},"item_4_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2021. The Author(s). "}]},"item_4_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2045-2322","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"NAKAMURA, Ryutaro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"KURIHARA, Mika"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"OGAWA, Nobuhiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"KITAMURA, Akihiro"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"YAMAKAWA, Isamu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"BAMBA, Shigeki"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"SANADA, Mitsuru"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"SASAKI, Masaya"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"URUSHITANI, Makoto"}],"nameIdentifiers":[{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-09-21"}],"displaytype":"detail","filename":"s41598-021-97196-5.pdf","filesize":[{"value":"1.6 MB"}],"format":"application/pdf","license_note":" This article is licensed under a Creative Commons Attribution 4.0 \nInternational License, which permits use, sharing, adaptation, \ndistribution and reproduction in any medium or format, as long as you \ngive appropriate credit to the original author(s) and the source, provide\na link to the Creative Commons licence, and indicate if changes were\nmade. The images or other third party material in this article are \nincluded in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in\nthe article's Creative Commons licence and your intended use is not\npermitted by statutory regulation or exceeds the permitted use, you \nwill need to obtain permission directly from the copyright holder. To\nview a copy of this licence, visit \nhttp://creativecommons.org/licenses/by/4.0/.","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"s41598-021-97196-5","url":"https://shiga-med.repo.nii.ac.jp/record/3977/files/s41598-021-97196-5.pdf"},"version_id":"d61a7f67-1e76-4915-8aa2-28e2724dc1bb"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Amyotrophic lateral sclerosis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Diseases","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Health care","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Medical research","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Neurology","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Predictive markers","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Prognostic markers","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Prognostic prediction by hypermetabolism varies depending on the nutritional status in early amyotrophic lateral sclerosis.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Prognostic prediction by hypermetabolism varies depending on the nutritional status in early amyotrophic lateral sclerosis."}]},"item_type_id":"4","owner":"11","path":["199","243"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-09-21"},"publish_date":"2021-09-21","publish_status":"0","recid":"3977","relation_version_is_last":true,"title":["Prognostic prediction by hypermetabolism varies depending on the nutritional status in early amyotrophic lateral sclerosis."],"weko_creator_id":"11","weko_shared_id":-1},"updated":"2023-06-19T11:22:04.530090+00:00"}