{"created":"2023-06-19T10:43:41.797131+00:00","id":3973,"links":{},"metadata":{"_buckets":{"deposit":"d2614644-4a9a-4292-a929-f8c4dd21c078"},"_deposit":{"created_by":11,"id":"3973","owners":[11],"pid":{"revision_id":0,"type":"depid","value":"3973"},"status":"published"},"_oai":{"id":"oai:shiga-med.repo.nii.ac.jp:00003973","sets":["19:34:35"]},"author_link":["8480","8613","4013","7626","1957","4013","7626","1957"],"control_number":"3973","item_4_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-09-02","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"17","bibliographicVolumeNumber":"26","bibliographic_titles":[{"bibliographic_title":"Molecules","bibliographic_titleLang":"en"}]}]},"item_4_creator_3":{"attribute_name":"著者別名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"田口, 弘康","creatorNameLang":"ja"},{"creatorName":"タグチ, ヒロヤス","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"4013","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"90102912","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=90102912"}]},{"creatorNames":[{"creatorName":"柳沢, 大治郎","creatorNameLang":"ja"},{"creatorName":"ヤナギサワ, ダイジロウ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"7626","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"50581112","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=50581112"}]},{"creatorNames":[{"creatorName":"遠山, 育夫","creatorNameLang":"ja"},{"creatorName":"トオヤマ, イクオ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"1957","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"20207533","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=20207533"},{"nameIdentifier":"0000-0001-8054-9666","nameIdentifierScheme":"ORCID","nameIdentifierURI":"https://orcid.org/0000-0001-8054-9666"}]}]},"item_4_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Thioredoxin-interacting protein (TXNIP) is involved in multiple disease-associated functions related to oxidative stress, especially by inhibiting the anti-oxidant- and thiol-reducing activity of thioredoxin (TXN). Shiga-Y5 (SY5), a fluorine-19 magnetic resonance probe for detecting amyloid-β deposition in the brain, previously showed therapeutic effects in a mouse model of Alzheimer's disease; however, the mechanism of action of SY5 remains unclear. SY5 passes the blood-brain barrier and then undergoes hydrolysis to produce a derivative, Shiga-Y6 (SY6), which is a TXNIP-negative regulator. Therefore, this study investigates the therapeutic role of SY5 as the prodrug of SY6 in the thioredoxin system in the brain of a mouse model of Alzheimer's disease. The intraperitoneal injection of SY5 significantly inhibited TXNIP mRNA (p = 0.0072) and protein expression (p = 0.0143) induced in the brain of APP/PS1 mice. In contrast, the levels of TXN mRNA (p = 0.0285) and protein (p = 0.0039) in the brain of APP/PS1 mice were increased after the injection of SY5. The ratio of TXN to TXNIP, which was decreased (p = 0.0131) in the brain of APP/PS1 mice, was significantly increased (p = 0.0072) after the injection of SY5. These results suggest that SY5 acts as a prodrug of SY6 in targeting the thioredoxin system and could be a potential therapeutic compound in oxidative stress-related diseases in the brain.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_4_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"MDPI","subitem_publisher_language":"en"}]},"item_4_relation_10":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"34500775","subitem_relation_type_select":"PMID"}}]},"item_4_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"en","subitem_relation_name_text":"10.3390/molecules26175342"}],"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.3390/molecules26175342","subitem_relation_type_select":"DOI"}}]},"item_4_relation_13":{"attribute_name":"PMCID","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"en","subitem_relation_name_text":"PMC8433978"}],"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.ncbi.nlm.nih.gov/pmc/articles/pmc8433978/","subitem_relation_type_select":"URI"}}]},"item_4_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2021 by the authors. Licensee MDPI, Basel, Switzerland.","subitem_rights_language":"en"}]},"item_4_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1420-3049","subitem_source_identifier_type":"EISSN"}]},"item_4_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"ARROZI, Aslina PAHRUDIN","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"8480","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"0000-0002-5776-7670","nameIdentifierScheme":"ORCID","nameIdentifierURI":"https://orcid.org/0000-0002-5776-7670"}]},{"creatorNames":[{"creatorName":"BAKAR, Zulzikry Hafiz Abu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"8613","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"0000-0002-8060-4220","nameIdentifierScheme":"ORCID","nameIdentifierURI":"https://orcid.org/0000-0002-8060-4220"}]},{"creatorNames":[{"creatorName":"TAGUCHI, Hiroyasu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"4013","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"90102912","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=90102912"}]},{"creatorNames":[{"creatorName":"YANAGISAWA, Daijiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"7626","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"50581112","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=50581112"}]},{"creatorNames":[{"creatorName":"TOOYAMA, Ikuo","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1957","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"20207533","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=20207533"},{"nameIdentifier":"0000-0001-8054-9666","nameIdentifierScheme":"ORCID","nameIdentifierURI":"https://orcid.org/0000-0001-8054-9666"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-09-15"}],"displaytype":"detail","filename":"molecules26175342.pdf","filesize":[{"value":"944.0 kB"}],"format":"application/pdf","licensefree":"This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited","licensetype":"license_0","mimetype":"application/pdf","url":{"label":"molecules26175342","objectType":"fulltext","url":"https://shiga-med.repo.nii.ac.jp/record/3973/files/molecules26175342.pdf"},"version_id":"ba0c8be7-e819-497c-ab2a-d1d7a1c676df"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Alzheimer’s disease","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"TXNIP","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"curcumin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"oxidative stress","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"thioredoxin","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"A Fluorine-19 Magnetic Resonance Probe, Shiga-Y5, Downregulates Thioredoxin-Interacting Protein Expression in the Brain of a Mouse Model of Alzheimer's Disease.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"A Fluorine-19 Magnetic Resonance Probe, Shiga-Y5, Downregulates Thioredoxin-Interacting Protein Expression in the Brain of a Mouse Model of Alzheimer's Disease.","subitem_title_language":"en"}]},"item_type_id":"4","owner":"11","path":["35"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2021-09-15"},"publish_date":"2021-09-15","publish_status":"0","recid":"3973","relation_version_is_last":true,"title":["A Fluorine-19 Magnetic Resonance Probe, Shiga-Y5, Downregulates Thioredoxin-Interacting Protein Expression in the Brain of a Mouse Model of Alzheimer's Disease."],"weko_creator_id":"11","weko_shared_id":-1},"updated":"2024-08-14T00:57:16.138355+00:00"}